3.4.22.B70: SENP1 peptidase
This is an abbreviated version!
For detailed information about SENP1 peptidase, go to the full flat file.
Word Map on EC 3.4.22.B70
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3.4.22.B70
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desumoylation
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deconjugating
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senp-1
-
medicine
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sumo-modified
-
senp1-mediated
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drug development
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ranbp2
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sumo-2
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diagnostics
- 3.4.22.B70
-
desumoylation
-
deconjugating
-
senp-1
- medicine
-
sumo-modified
-
senp1-mediated
- drug development
- ranbp2
- sumo-2
- diagnostics
Reaction
The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO-1, SUMO-2 and SUMO-3 from targeted proteins. Deconjugates SUMO-1 from homeodomain-interacting protein kinase 2. Deconjugates SUMO-1 from histone deacetylase 1, which decreases its transcriptional repression activity. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =
Synonyms
C13orf22l, SENP, SENP1, sentrin-specific protease 1, sentrin/SUMO-specific protease 1, small ubiquitin-like modifier protein-specific protease 1, small ubiquitin-related modifier-specific isopeptidase, SUMO isopeptidase, SUMO protease, SUMO protein-specific protease 1, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 1, ubiquitin-specific protease-like 1, USPL1
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Reference on EC 3.4.22.B70 - SENP1 peptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, Z.; Chau, S.F.; Lam, K.H.; Chan, H.Y.; Ng, T.B.; Au, S.W.
Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease
Biochem. J.
398
345-352
2006
Homo sapiens (Q9P0U3)
Cheng, J.; Kang, X.; Zhang, S.; Yeh, E.T.
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
Cell
131
584-595
2007
Mus musculus (P59110)
Bawa-Khalfe, T.; Cheng, J.; Wang, Z.; Yeh, E.T.
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells
J. Biol. Chem.
282
37341-37349
2007
Homo sapiens
Shen, L.; Tatham, M.H.; Dong, C.; Zagorska, A.; Naismith, J.H.; Hay, R.T.
SUMO protease SENP1 induces isomerization of the scissile peptide bond
Nat. Struct. Mol. Biol.
13
1069-1077
2006
Homo sapiens (Q9P0U3)
Rimsa, V.; Eadsforth, T.; Hunter, W.N.
The role of Co2+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols
Acta Crystallogr. Sect. F
67
442-445
2011
Homo sapiens (Q9P0U3), Homo sapiens
Yates, K.E.; Korbel, G.A.; Shtutman, M.; Roninson, I.B.; DiMaio, D.
Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts
Aging Cell
7
609-621
2008
Homo sapiens (Q9P0U3)
Ohbayashi, N.; Kawakami, S.; Muromoto, R.; Togi, S.; Ikeda, O.; Kamitani, S.; Sekine, Y.; Honjoh, T.; Matsuda, T.
The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
Biochem. Biophys. Res. Commun.
371
823-828
2008
Homo sapiens (Q9P0U3)
Xu, Z.; Au, S.W.
Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1
Biochem. J.
386
325-330
2005
Homo sapiens (Q9P0U3)
Shen, L.N.; Dong, C.; Liu, H.; Naismith, J.H.; Hay, R.T.
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing
Biochem. J.
397
279-288
2006
Homo sapiens (Q9P0U3)
Witty, J.; Aguilar-Martinez, E.; Sharrocks, A.D.
SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
Biochem. J.
428
247-254
2010
Homo sapiens (Q9P0U3)
Brems-Eskildsen, A.S.; Zieger, K.; Toldbod, H.; Holcomb, C.; Higuchi, R.; Mansilla, F.; Munksgaard, P.P.; Borre, M.; Orntoft, T.F.; Dyrskjot, L.
Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts
BMC Cancer
10
646
2010
Homo sapiens
Xu, Y.; Li, J.; Zuo, Y.; Deng, J.
Wang, L.S.; Chen, G.Q.: SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors
Cancer Lett.
309
78-84
2011
Homo sapiens
Li, X.; Luo, Y.; Yu, L.; Lin, Y.; Luo, D.; Zhang, H.; He, Y.; Kim, Y.O.; Kim, Y.; Tang, S.; Min, W.
SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis
Cell Death Differ.
15
739-750
2008
Homo sapiens (Q9P0U3)
Dai, X.Q.; Plummer, G.; Casimir, M.; Kang, Y.; Hajmrle, C.; Gaisano, H.Y.; Manning Fox, J.E.; MacDonald, P.E.
SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans
Diabetes
60
838-847
2011
Mus musculus (P59110)
Kim, Y.H.; Sung, K.S.; Lee, S.J.; Kim, Y.O.; Choi, C.Y.; Kim, Y.
Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1
FEBS Lett.
579
6272-6278
2005
Homo sapiens (Q9P0U3)
Bawa-Khalfe, T.; Yeh, E.T.
SUMO losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression
Genes Cancer
1
748-752
2010
Homo sapiens
Bailey, D.; O'Hare, P.
Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1
J. Biol. Chem.
279
692-703
2004
Homo sapiens
Bawa-Khalfe, T.; Cheng, J.; Lin, S.H.; Ittmann, M.M.; Yeh, E.T.
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms
J. Biol. Chem.
285
25859-25866
2010
Mus musculus (P59110)
Xu, Y.; Zuo, Y.; Zhang, H.; Kang, X.; Yue, F.; Yi, Z.; Liu, M.; Yeh, E.T.; Chen, G.; Cheng, J.
Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis
J. Biol. Chem.
285
36682-36688
2010
Homo sapiens (Q9P0U3)
Yu, L.; Ji, W.; Zhang, H.; Renda, M.J.; He, Y.; Lin, S.; Cheng, E.C.; Chen, H.; Krause, D.S.; Min, W.
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis
J. Exp. Med.
207
1183-1195
2010
Mus musculus (P59110)
Cheng, J.; Wang, D.; Wang, Z.; Yeh, E.T.
SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1
Mol. Cell. Biol.
24
6021-6028
2004
Homo sapiens (Q9P0U3)
Kaikkonen, S.; Jääskeläinen, T.; Karvonen, U.; Rytinki, M.M.; Makkonen, H.; Gioeli, D.; Paschal, B.M.; Palvimo, J.J.
SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells
Mol. Endocrinol.
23
292-307
2009
Homo sapiens (Q9P0U3)
Shin, Y.C.; Liu, B.Y.; Tsai, J.Y.; Wu, J.T.; Chang, L.K.; Chang, S.C.
Biochemical characterization of the small ubiquitin-like modifiers of Chlamydomonas reinhardtii
Planta
232
649-662
2010
Homo sapiens
Plant, L.D.; Dementieva, I.S.; Kollewe, A.; Olikara, S.; Marks, J.D.; Goldstein, S.A.
One SUMO is sufficient to silence the dimeric potassium channel K2P1
Proc. Natl. Acad. Sci. USA
107
10743-10748
2010
Homo sapiens (Q9P0U3), Homo sapiens
Qiao, Z.; Wang, W.; Wang, L.; Wen, D.; Zhao, Y.; Wang, Q.; Meng, Q.; Chen, G.; Wu, Y.; Zhou, H.
Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors
Bioorg. Med. Chem. Lett.
21
6389-6392
2011
Homo sapiens
Chen, Y.; Wen, D.; Huang, Z.; Huang, M.; Luo, Y.; Liu, B.; Lu, H.; Wu, Y.; Peng, Y.; Zhang, J.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation
Bioorg. Med. Chem. Lett.
22
6867-6870
2012
Homo sapiens
Yan, X.M.; Xu, Z.Q.; Zhou, Y.; Wang, J.; Pan, J.; Yuan, L.Q.; Fu, M.C.; Xia, H.L.; Cao, X.; Zhang, T.
SENP1 regulates cell migration and invasion in neuroblastoma
Biotechnol. Appl. Biochem.
63
435-440
2016
Homo sapiens
Chen, C.H.; Chang, C.C.; Lee, T.H.; Luo, M.; Huang, P.; Liao, P.H.; Wei, S.; Li, F.A.; Chen, R.H.; Zhou, X.Z.; Shih, H.M.; Lu, K.P.
SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function
Cancer Res.
73
3951-3962
2013
Homo sapiens
Sharma, P.; Yamada, S.; Lualdi, M.; Dasso, M.; Kuehn, M.R.
Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryo
Cell Rep.
3
1640-1650
2013
Mus musculus
Schulz, S.; Chachami, G.; Kozaczkiewicz, L.; Winter, U.; Stankovic-Valentin, N.; Haas, P.; Hofmann, K.; Urlaub, H.; Ovaa, H.; Wittbrodt, J.; Meulmeester, E.; Melchior, F.
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions
EMBO Rep.
13
930-938
2012
Danio rerio, Homo sapiens (Q5W0Q7)
Cai, R.; Yu, T.; Huang, C.; Xia, X.; Liu, X.; Gu, J.; Xue, S.; Yeh, E.T.; Cheng, J.
SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1alpha
J. Biol. Chem.
287
44464-44470
2012
Homo sapiens
Liu, B.; Wang, T.; Mei, W.; Li, D.; Cai, R.; Zuo, Y.; Cheng, J.
Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation
J. Biol. Chem.
289
22358-22364
2014
Homo sapiens (Q9P0U3)
Cubenas-Potts, C.; Goeres, J.D.; Matunis, M.J.
SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis
Mol. Biol. Cell
24
3483-3495
2013
Homo sapiens (Q9P0U3)
Chow, K.H.; Elgort, S.; Dasso, M.; Powers, M.A.; Ullman, K.S.
The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
Mol. Biol. Cell
25
160-168
2014
Homo sapiens
Chen, C.H.; Namanja, A.T.; Chen, Y.
Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding
Nat. Commun.
5
4968
2014
Homo sapiens
Chow, K.H.; Elgort, S.; Dasso, M.; Ullman, K.S.
Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2
Nucleus
3
349-358
2012
Homo sapiens
Wu, R.; Cui, Y.; Yuan, X.; Yuan, H.; Wang, Y.; He, J.; Zhao, J.; Peng, S.
SUMO-specific protease 1 modulates cadmium-augmented transcriptional activity of androgen receptor (AR) by reversing AR SUMOylation
Toxicol. Lett.
229
405-413
2014
Homo sapiens
Ma, C.; Wu, B.; Huang, X.; Yuan, Z.; Nong, K.; Dong, B.; Bai, Y.; Zhu, H.; Wang, W.; Ai, K.
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9
Tumour Biol.
35
12729-12735
2014
Homo sapiens
Zhang, C.; Li, J.; Qiu, X.; Chen, Y.; Zhang, X.
SUMO protease SENP1 acts as a ceRNA for TGFBR2 and thus activates TGFBR2/Smad signaling responsible for LPS-induced sepsis
Biomed. Pharmacother.
112
108620
2019
Homo sapiens (Q9P0U3)
Burdelski, C.; Menan, D.; Tsourlakis, M.C.; Kluth, M.; Hube-Magg, C.; Melling, N.; Minner, S.; Koop, C.; Graefen, M.; Heinzer, H.; Wittmer, C.; Sauter, G.; Simon, R.; Schlomm, T.; Steurer, S.; Krech, T.
The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion
BMC Cancer
15
538
2015
Homo sapiens (Q9P0U3)
Huang, X.; Zuo, Y.; Wang, X.; Wu, X.; Tan, H.; Fan, Q.; Dong, B.; Xue, W.; Chen, G.Q.; Cheng, J.
SUMO-specific protease 1 is critical for myeloid-derived suppressor cell development and function
Cancer Res.
79
3891-3902
2019
Mus musculus (P59110)
Zhang, H.; Wang, Y.; Zhu, A.; Huang, D.; Deng, S.; Cheng, J.; Zhu, M.X.; Li, Y.
SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion
Cell Death Dis.
7
e2484
2016
Mus musculus (P59110)
Xia, W.; Tian, H.; Cai, X.; Kong, H.; Fu, W.; Xing, W.; Wang, Y.; Zou, M.; Hu, Y.; Xu, D.
Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-kappaB/Akt pathways
Gene
595
175-179
2016
Homo sapiens (Q9P0U3), Homo sapiens
Zhang, X.; Wang, H.; Wang, H.; Xiao, F.; Seth, P.; Xu, W.; Jia, Q.; Wu, C.; Yang, Y.; Wang, L.
SUMO-specific cysteine protease 1 promotes epithelial mesenchymal transition of prostate cancer cells via regulating SMAD4 deSUMOylation
Int. J. Mol. Sci.
18
808
2017
Homo sapiens
Rodriguez-Castaneda, F.; Lemma, R.B.; Cuervo, I.; Bengtsen, M.; Moen, L.M.; Ledsaak, M.; Eskeland, R.; Gabrielsen, O.S.
The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression
J. Biol. Chem.
293
15439-15454
2018
Homo sapiens (Q9P0U3)
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