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(SUMO-1)-androgen receptor conjugate + H2O
SUMO-1 + androgen receptor conjugate
SENP1 markedly contributes to the androgen-stimulated proliferation of prostate cancer cells
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(SUMO-1)-histone deacetylase 1 conjugate + H2O
SUMO-1 + histone deacetylase 1
SENP1 regulates that androgen receptor-dependent transcription through desumoylation of histone deacetylase 1 (HDAC1)
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(SUMO-1)-homeodomain-interacting protein kinase 2 conjugate + H2O
SUMO-1 + homeodomain-interacting protein kinase 2 conjugate
desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) may be regulated by the cytoplasmic-nuclear shuttling of SENP1. Desumoylation induces dissociation of homeodomain-interacting protein kinase 2 conjugate from nuclear bodies
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(SUMO-1)-K2P1 potassium channel + H2O
SUMO-1 + K2P1 potassium channel
silent K2P1 channels in excised plasma membrane patches are activated by SENP1
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Pin1 + H2O
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Pin1 is SUMOylated on Lys6 in the WW domain and on Lys63 in the PPIase domain, deSUMOlation by SENP1
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pro-small ubiquitin-related modifier + H2O
small ubiquitin-related modifier + ?
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SENP1 processes the precursor SUMO to its mature form by catalyzing the cleavage of a scissile peptide bond
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Sharp-1 protein + H2O
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deSUMOylation by the enzyme
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small ubiquitin-related modifier-protein + H2O
small ubiquitin-related modifier-protein + protein
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SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins
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SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
cleavage of the -Gly-Gly-/-His-Ser-Thr-Val bond. The maturation reaction is the first committed step for subsequent sumoylation
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SUMO-2 precursor + H2O
SUMO-2 + Val-Tyr
cleavage of the -Gly-Gly-/-Val-Tyr. The maturation reaction is the first committed step for subsequent sumoylation
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SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
cleavage of the -Gly-Gly-/-Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe bond. The maturation reaction is the first committed step for subsequent sumoylation
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SUMO-Elk-1 conjugate + H2O
SUMO + Elk-1
SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
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SUMO-GATA 1 conjugate + H2O
SUMO + GATA1
SENP1 promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1
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SUMO-hypoxia-inducible factor 1 conjugate + H2O
SUMO + hypoxia-inducible factor 1
SUMO-STAT3 protein conjugate + H2O
SUMO + STAT3 protein
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SUMO1ylated protein + H2O
SUMO1 + protein
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main substrate
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SUMO2ylated protein + H2O
SUMO2 + protein
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SUMO3ylated protein + H2O
SUMO3 + protein
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additional information
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SUMO-hypoxia-inducible factor 1 conjugate + H2O
SUMO + hypoxia-inducible factor 1
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SUMO-hypoxia-inducible factor 1 conjugate + H2O
SUMO + hypoxia-inducible factor 1
deSUMOylation plays a critical role in prostate pathogenesis through induction of HIF1alpha-dependent angiogenesis and enhanced cell proliferation
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additional information
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enzyme USPL1 neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase both in vitro and in cells
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additional information
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enzyme USPL1 neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase both in vitro and in cells
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additional information
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nucleoporin Nup153 binds to SENP1 by interacting with the unique N-terminal domain of Nup153 as well as a specific region within the C-terminal FG-rich region. Nup153 is a substrate for SUMOylation, with this modification kept in check by the SUMO protease
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additional information
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the enzyme SUMO protease removes SUMO conjugate from proteins
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