3.4.21.84: limulus clotting factor C
This is an abbreviated version!
For detailed information about limulus clotting factor C, go to the full flat file.
Word Map on EC 3.4.21.84
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3.4.21.84
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endothelial
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vegf-c
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lymphatic
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metastasis
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node
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lymphangiogenesis
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lymph
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vessel
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lymphangiogenic
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clinicopathological
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coagulation
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horseshoe
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crab
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azoospermia
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platelet-derived
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endotoxin
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receptor-3
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microdeletions
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microvessels
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factor-c
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lymphedema
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zymogen
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hemocytes
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podoplanin
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tachypleus
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tridentatus
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lyve-1
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y-chromosome
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amebocyte
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oligozoospermia
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lps-binding
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loader
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analysis
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pdgfc
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sushi
- 3.4.21.84
- endothelial
- vegf-c
- lymphatic
- metastasis
- node
-
lymphangiogenesis
- lymph
- vessel
-
lymphangiogenic
-
clinicopathological
-
coagulation
-
horseshoe
- crab
- azoospermia
-
platelet-derived
- endotoxin
- receptor-3
-
microdeletions
-
microvessels
- factor-c
- lymphedema
- zymogen
- hemocytes
- podoplanin
- tachypleus
- tridentatus
-
lyve-1
-
y-chromosome
-
amebocyte
- oligozoospermia
-
lps-binding
-
loader
- analysis
-
pdgfc
-
sushi
Reaction
Selective cleavage of -Arg103-/-Ser- and -Ile124-/-Ile- bonds in limulus clotting factor B to form factor _overbar_B_. Cleavage of -Pro-Arg-/- bonds in synthetic substrates =
Synonyms
CrFC, Factor C, IscW_ISCW002489, Limulus factor C
ECTree
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General Information
General Information on EC 3.4.21.84 - limulus clotting factor C
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metabolism
physiological function
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factor C is involved in the LPS reactive coagulation cascade system in the Limulus horseshoe crab that results in the formation of a coagulin gel
metabolism
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the enzyme is part of the clotting cascade of Limulus polyphemus. Factor C, the first component of the cascade, is a serine protease that is activated by endotoxin binding. The cascade, initiated by lipopolysaccharide, culminates in the activation of the pro-clotting enzyme to its active form, the clotting enzyme, which in turn acts on coagulogen to convert it into the coagulin clot
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RNAi silencing results in a significant reduction in phagocytic activity of tick hemocytes against the Gram-negative bacteria Chryseobacterium indologenes and Escherichia coli, but not against the yeast, Candida albicans
physiological function
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Factor C activates factor B in the clotting cascade in Limulus polyphemus