3.4.21.60: Scutelarin
This is an abbreviated version!
For detailed information about Scutelarin, go to the full flat file.
Word Map on EC 3.4.21.60
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3.4.21.60
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clot
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anticoagulant
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coagulation
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venom
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thromboplastin
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snake
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chromogenic
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dabigatran
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bleeding
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thrombocytopenia
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procoagulant
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carinatus
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heparin-induced
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meizothrombin
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etexilate
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viper
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argatroban
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echis
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r-hirudin
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lepirudin
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prothrombinase
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rivaroxaban
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textilis
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pseudonaja
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lonomia
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anti-factor
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anti-xa
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doacs
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apixaban
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idarucizumab
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hemoclot
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bivalirudin
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elapid
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prothrombinase-induced
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obliqua
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prethrombin-2
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tropidechis
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melagatran
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medicine
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edoxaban
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saw-scaled
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peg-hirudin
- 3.4.21.60
- clot
-
anticoagulant
- coagulation
- venom
- thromboplastin
- snake
-
chromogenic
- dabigatran
-
bleeding
- thrombocytopenia
-
procoagulant
- carinatus
-
heparin-induced
- meizothrombin
-
etexilate
- viper
- argatroban
- echis
-
r-hirudin
- lepirudin
- prothrombinase
- rivaroxaban
- textilis
- pseudonaja
- lonomia
-
anti-factor
-
anti-xa
-
doacs
- apixaban
-
idarucizumab
-
hemoclot
- bivalirudin
-
elapid
-
prothrombinase-induced
- obliqua
- prethrombin-2
-
tropidechis
- melagatran
- medicine
- edoxaban
-
saw-scaled
-
peg-hirudin
Reaction
selective cleavage of Arg-/-Thr and Arg-/-Ile in prothrombin to form thrombin and two inactive fragments =
Synonyms
cotiaractivase, cotiarinase, EC 3.4.99.28, ecarin, Lopap, Proteinase, Oxyuranus scutellatus prothrombin-activating, prothrombin activator, pseutarin C, scuterin, Taipan activator
ECTree
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Inhibitors
Inhibitors on EC 3.4.21.60 - Scutelarin
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benzamidine
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inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
Bovine pancreas trypsin inhibitor
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inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
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Inhibitor present in the venom of Oxyuranus scutellatus
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inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
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NaCl
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inhibits activation of prethrombin 2, no effect on reaction with meizothrombin
Nalpha-p-toluenesulfonyl-L-Arg methyl ester
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inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
NaSCN
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bovine factor Va restores activity; reduces ability to activate prothrombin but has no effect on amidolytic activity
Soybean trypsin inhibitor
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inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
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additional information
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hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4nitroanilide is insensitive to: diisopropyl fluorophosphate, antithrombin III, chicken ovomucoid trypsin inhibitor, EDTA, 1,10-phenanthroline, activated protein C
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