3.4.14.6: dipeptidyl-dipeptidase

This is an abbreviated version!
For detailed information about dipeptidyl-dipeptidase, go to the full flat file.

Reaction

preferential release of dipeptides from a tetrapeptide, e.g. Ala-Gly-/-Ala-Gly. Acts additional information slowly on Ala-Ala-/-Ala-Ala and Gly-Gly-/-Gly-Gly =

Synonyms

dipeptidyl ligase, dipeptidyl tetrapeptide hydrolase, hydrolase, dipeptidyl tetrapeptide, tetrapeptide dipeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

                3.4.14.6 dipeptidyl-dipeptidase

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Results	in table
1	Activating Compound
1	CAS Registry Number
4	Inhibitors
2	Organism
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
2	Reaction Type
2	Reference
1	Source Tissue
2	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
4	Synonyms
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 3.4.14.6 - dipeptidyl-dipeptidase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

Ala-Gly

Ala-Gly-Ala-Gly + H2O

Brassica oleracea

-

-

36266

-

36266

r

Ala-Gly-Ala-Gly + H2O

2 Ala-Gly

Brassica oleracea

-

-

36266

-

36266

r

Gly-Gly + H2O

Gly-Gly-Gly-Gly

Brassica oleracea

-

-

36266

-

36266

r

Gly-Gly-Gly-Gly + H2O

Gly-Gly

Brassica oleracea

-

-

36266

-

36266

r

Gly-L-Ala + H2O

Gly-Ala-Gly-Ala

Brassica oleracea

-

-

36266

-

36266

?

L-Ala-L-Ala + H2O

Ala-Ala-Ala-Ala

Brassica oleracea

-

-

36266

-

36266

?

L-Met-Gly + H2O

?

Brassica oleracea

-

very slowly

36266

-

-

?

additional information

?

-

Brassica oleracea

-

tetrapeptides are formed from Ala-Ala, Gly-Gly, Ala-Gly and Gly-Ala without prior activation of the carboxyl group, condensation reaction: substrate specificity for a dipeptide with either two Ala residues or one Ala and one Gly residue, not hydrolyzed: pentaglycine, no condensation reaction with: Ser-Gly, Ala-Ala-Gly, Gly-Gly-Ala, Gly-Gly-Gly, Gly-Gly-leu, beta-Ala-Gly, Gly-leu, D-Ala-L-Ala, Gly-D-Ala

36266

-

-

?