3.2.1.102: blood-group-substance endo-1,4-beta-galactosidase
This is an abbreviated version!
For detailed information about blood-group-substance endo-1,4-beta-galactosidase, go to the full flat file.
Word Map on EC 3.2.1.102
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3.2.1.102
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epitope
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xenotransplantation
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clostridium
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alphagal
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perfringens
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galalpha1-3gal
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xenoantigenic
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hyperacute
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galalpha1-3galbeta1-4glcnac
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alpha-galactosyl
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saporin
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medicine
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analysis
- 3.2.1.102
- epitope
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xenotransplantation
- clostridium
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alphagal
- perfringens
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galalpha1-3gal
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xenoantigenic
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hyperacute
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galalpha1-3galbeta1-4glcnac
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alpha-galactosyl
- saporin
- medicine
- analysis
Reaction
Synonyms
ABase, blood group A- and B-cleaving endo-beta-galactosidase, blood group A/B antigen-specific endo-beta-galactosidase, blood group antigen-cleaving endo-beta-galactosidase, blood group glycotope-cleaving endo-beta-galactosidase, E-ABase, EABase, endo-beta-galactosidase, endo-beta-galactosidase C, endo-beta-galactosidase DII, EndoGalC, galactosidase, endo-beta-, GH98CBM51, inverting endo-beta-galactosidase, More, Sp3GH98, Sp4GH98
ECTree
3.2.1.102 blood-group-substance endo-1,4-beta-galactosidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.2.1.102 - blood-group-substance endo-1,4-beta-galactosidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,4-dinitrophenyl 2-acetamido-2-deoxy-D-galactopyranosyl-(1,3)-[alpha-L-fucopyranosyl-(1,2)]-beta-D-galactopyranoside + H2O
?
-
-
-
-
?
blood group O glycopeptide + H2O
GlcNAcbeta1-3Gal-ol + Galbeta1-4GlcNAcbeta1-3Gal-ol + Fucalpha1-2Galbeta1-4GlcNAcbeta1-3Gal-ol + GlcNAcbeta1-6[GlcNAcbeta1-3]Galbeta1-4GlcNAcbeta1-3Gal-ol + Galbeta1-4GlcNAcbeta1-6[GlcNAcbeta1-3]Galbeta1-4GlcNAcbeta1-3Gal-ol + GlcNAcbeta1-6[Galbeta1-4GlcNAcbeta1-3]Galbeta1-4GlcNAcbeta1-3Gal-ol + Galbeta1-4GlcNAcbeta1-6[Galbeta1-4GlcNAcbeta1-3]Galbeta1-4GlcNAcbeta1-3Gal-ol + Fucalpha1-2Galbeta1-4GlcNAcbeta1-6[GlcNAcbeta1-3]Galbeta1-4GlcNAcbeta1-3Gal-ol + Fucalpha1-2Galbeta1-4GlcNAcbeta1-6[Galbeta1-4GlcNAcbeta1-3]Galbeta1-4GlcNAcbeta1-3Gal-ol + Fucalpha1-2Galbeta1-4GlcNAcbeta1-6[Fucalpha1-2Galbeta1-4GlcNAcbeta1-3]Galbeta1-4GlcNAcbeta1-3Gal-ol
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desialylated human blood group O erythrocyte glycopeptide
characterization of the oligosaccharides
?
blood group substance A + H2O
GalNAcalpha1-3(Fucalpha1-2)Gal + Galalpha1-3(Fucalpha1-2)Gal + ?
-
degradation of blood type A determinant
-
?
blood group substance B + H2O
?
-
degradation of blood type B determinant
-
-
?
Galalpha(1-3)[Fucalpha(1-2)]Galbeta(1-4)GlcNAcbeta-CH2-CH2-N3 + H2O
?
-
analog of blood group B antigen
-
-
?
Galalpha(1-3)[Fucalpha(1-2)]Galbeta(1-4)GlcNAcbeta-R + H2O
Galalpha(1-3)[Fucalpha(1-2)]Gal + GlcNAcbeta-R
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analog of blood group B antigen, digested more effciently than the blood group A analog
-
-
?
Galalpha1-3(Fucalpha1-2)Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3-hexene-1,2,5,6-tetrol + H2O
?
-
-
-
-
?
Galalpha1-3(Fucalpha1-2)Galbeta1-4GlcNAcbeta1-3-hexene-1,2,5,6-tetrol + H2O
?
-
-
-
-
?
Galalpha1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + H2O
Galalpha1-3Galbeta + GlcNAcbeta1-3Galbeta1-4Glc
-
-
-
-
?
Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-3GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta + GlcNAcbeta-p-nitrophenol
Galbeta1-6GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-6GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
GalNAcalpha(1-3)[Fucalpha(1-2)]Galbeta(1-4)GlcNAcbeta-CH2-CH2-N3 + H2O
?
-
analog of blood group A antigen
-
-
?
GalNAcalpha(1-3)[Fucalpha(1-2)]Galbeta(1-4)GlcNAcbeta-R + H2O
GalNAcalpha(1-3)[Fucalpha(1-2)]Gal + GlcNAcbeta-R
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analog of blood group A antigen
-
-
?
GalNAcalpha1-3(Fucalpha1-2)Galbeta1-4GlcNAcbeta1-3-hexene-1,2,5,6-tetrol + H2O
?
-
-
-
-
?
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
GlcNAcbeta1-3Galbeta + GlcNAcbeta-p-nitrophenol
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol
lactosaminoglycan + H2O
small oligosaccharides + residual glycopeptide
-
-
-
?
blood group A glycoconjugate + H2O
?
substrate from human erythrocytes and from porcine gastric mucin, liberation of the A trisaccharide GalNAcalpha(1-3)fucosealpha(1-2)galactose, product identification by NMR
-
-
?
blood group A glycoconjugate + H2O
?
substrate from human erythrocytes and from porcine gastric mucin, liberation of the A trisaccharide GalNAcalpha(1-3)fucosealpha(1-2)galactose, product identification by NMR
-
-
?
blood group A glycoconjugate + H2O
?
-
Sp3GH98 is specific for the Galbeta1-4GlcNAc (type 2 core chain) linkage over either the Galbeta1-3GlcNAc (type 1 core chain) linkage or the Galbeta1-3GalNAc (type 4 core chain) and liberates the terminal GalNAcalpha1-3(Fucalpha1-2)Gal trisaccharide of the A antigen
-
-
?
blood group A glycoconjugate + H2O
?
-
Sp3GH98 is specific for the Galbeta1-4GlcNAc (type 2 core chain) linkage over either the Galbeta1-3GlcNAc (type 1 core chain) linkage or the Galbeta1-3GalNAc (type 4 core chain) and liberates the terminal GalNAcalpha1-3(Fucalpha1-2)Gal trisaccharide of the A antigen
-
-
?
blood group B glycoconjugate + H2O
?
substrate from human erythrocytes and human ovarian cyst, liberation of the B trisaccharide Galalpha(1-3)fucosealpha(1-2)galactose, product identification by NMR
-
-
?
blood group B glycoconjugate + H2O
?
substrate from human erythrocytes and human ovarian cyst, liberation of the B trisaccharide Galalpha(1-3)fucosealpha(1-2)galactose, product identification by NMR
-
-
?
blood group B glycoconjugate + H2O
?
-
Sp3GH98 is specific for the Galbeta1-4GlcNAc (type 2 core chain) linkage over either the Galbeta1-3GlcNAc (type 1 core chain) linkage or the Galbeta1-3GalNAc (type 4 core chain) and liberates the terminal Galalpha1-3(Fucalpha1-22)Gal trisaccharide of the B antigen
-
-
?
blood group B glycoconjugate + H2O
?
-
Sp3GH98 is specific for the Galbeta1-4GlcNAc (type 2 core chain) linkage over either the Galbeta1-3GlcNAc (type 1 core chain) linkage or the Galbeta1-3GalNAc (type 4 core chain) and liberates the terminal Galalpha1-3(Fucalpha1-22)Gal trisaccharide of the B antigen
-
-
?
Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-3GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
-
-
-
-
?
Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-3GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
-
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
-
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
-
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta + GlcNAcbeta-p-nitrophenol
-
-
-
-
?
Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
Galbeta1-4GlcNAcbeta1-3Galbeta + GlcNAcbeta-p-nitrophenol
-
-
-
-
?
Galbeta1-6GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-6GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
-
-
-
-
?
Galbeta1-6GlcNAcbeta1-3Galbeta1-4Glcbeta-p-nitrophenol + H2O
Galbeta1-6GlcNAcbeta1-3Galbeta + Glcbeta-p-nitrophenol
-
-
-
-
?
GlcNAcbeta1-3Galbeta1-4Glc-p-nitrophenol + H2O
GlcNAcbeta1-3Galbeta + Glc-p-nitrophenol
-
-
-
-
?
GlcNAcbeta1-3Galbeta1-4Glc-p-nitrophenol + H2O
GlcNAcbeta1-3Galbeta + Glc-p-nitrophenol
-
-
-
-
?
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
GlcNAcbeta1-3Galbeta + GlcNAcbeta-p-nitrophenol
-
-
-
-
?
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
GlcNAcbeta1-3Galbeta + GlcNAcbeta-p-nitrophenol
-
-
-
-
?
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol
-
transglycosylation activity at high substrate concentration (8.4%)
-
-
?
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + H2O
GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol + GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-p-nitrophenol
-
transglycosylation activity at high substrate concentration (8.4%)
-
-
?
LewisY tetrasaccharide + H2O
?
-
Sp4GH98 is able to hydrolyze the Galbeta1-4GalNAc linkage within the LewisY antigen
-
-
?
LewisY tetrasaccharide + H2O
?
-
Sp4GH98 is able to hydrolyze the Galbeta1-4GalNAc linkage within the LewisY antigen
-
-
?
additional information
?
-
-
hydrolyzes linear but not branched oligosaccharide domains of glycolipids of the neolacto series. At an optimal concentration of detergent the endo-beta-galactosidase susceptibility of the GlcNAcbeta1-3Galbeta1-4Glc sequence near the ceramide moiety of the branched glycolipids is similar to that of the corresponding sequence in the linear glycolipids
-
-
?
additional information
?
-
-
treatment of human erythrocytes with the enzyme converts protein 3, the anion transporter of the erythrocyte, to a more compact staining band
-
-
?
additional information
?
-
-
band 3 glycopeptide of cord and i variant adult human erythrocytes are hydrolyzed to mostly small oligosaccharides by endo-beta-galactosidase from Escherichia freundii, whereas that of normal adult produces a number of oligosaccharides with various sizes which is caused by branched structures
-
-
?
additional information
?
-
-
hydrolyzes linear but not branched oligosaccharide domains of glycolipids of the neolacto series. At an optimal concentration of detergent the endo-beta-galactosidase susceptibility of the GlcNAcbeta1-3Galbeta1-4Glc sequence near the ceramide moiety of the branched glycolipids is similar to that of the corresponding sequence in the linear glycolipids
-
-
?
additional information
?
-
-
directly modifies specific cell surface glycoconjugates: abolishment of Ii-antigenic activity, decrease of the reactivity with anti-ABH blood group and anti-paragloboside antibodies, a slight but distinct increase of the reactivity with anti-lacto-N-triosylceramide antibodies, no change of the reactivity with anti-globoside antibodies
-
-
?
additional information
?
-
-
endo-beta-galactosidase C cleaves Galbeta1-4GlcNAc linkage and is capable of digesting alphaGal epitopes comprising two galactosyl residues at the distal end of the glycan
-
-
?
additional information
?
-
-
hydrolyzes linear N-acetyllactosamine repeating structures in glycolipids and glycopeptides to release oligosaccharides. Branched lactosaminyl glycolipids and H-antigenic glycolipids are resistant to endo-beta-galactosidase DII, even when linear structure is present at the inner part. The enzyme releases mostly small oligosaccharides from substrates, stepwise release from the nonreducing terminal. No degradation of keratan sulfate
-
-
?
additional information
?
-
-
acts specifically on the oligosaccharides with blood group A and B antigenic determinants composed of type 2 chains: the A determinant present in erythrocyte glycoproteins is completely hydrolyzed
-
-
?
additional information
?
-
-
Sp3GH98 does not cleave the LewisY tetrasaccharide
-
-
?
additional information
?
-
-
Sp3GH98 does not cleave the LewisY tetrasaccharide
-
-
?
