2.4.1.5: dextransucrase
This is an abbreviated version!
For detailed information about dextransucrase, go to the full flat file.
Word Map on EC 2.4.1.5
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2.4.1.5
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streptococcus
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mutans
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glucosylation
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glucans
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leuconostoc
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dental
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mesenteroides
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caries
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udp-glucose
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oligosaccharide
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cariogenic
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sobrinus
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glucoside
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water-insoluble
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difficile
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plaque
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maltose
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glycosyltransferases
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serotype
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saliva
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tooth
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sanguis
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gordonii
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fructosyltransferase
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udp-glc
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monoglucosylated
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dextranase
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tcda
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glucansucrase
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pellicle
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salivarius
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gtases
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galactosyltransferase
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saliva-coated
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calnexin
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viscosus
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lipid-linked
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industry
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food industry
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aureobasidium
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oralis
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pharmacology
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pseudomembranous
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medicine
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3-o-glucoside
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levansucrase
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biotechnology
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alpha-1,6
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weissella
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man9glcnac2
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transglucosylation
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synthesis
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glc3man9glcnac2
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nutrition
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isomaltose
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sordellii
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holotoxins
- 2.4.1.5
- streptococcus
- mutans
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glucosylation
- glucans
- leuconostoc
-
dental
- mesenteroides
- caries
- udp-glucose
- oligosaccharide
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cariogenic
- sobrinus
- glucoside
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water-insoluble
- difficile
- plaque
- maltose
- glycosyltransferases
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serotype
- saliva
- tooth
- sanguis
- gordonii
- fructosyltransferase
- udp-glc
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monoglucosylated
- dextranase
- tcda
- glucansucrase
- pellicle
- salivarius
- gtases
-
galactosyltransferase
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saliva-coated
- calnexin
- viscosus
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lipid-linked
- industry
- food industry
- aureobasidium
- oralis
- pharmacology
-
pseudomembranous
- medicine
- 3-o-glucoside
- levansucrase
- biotechnology
-
alpha-1,6
- weissella
- man9glcnac2
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transglucosylation
- synthesis
- glc3man9glcnac2
- nutrition
- isomaltose
- sordellii
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holotoxins
Reaction
Synonyms
B-512F dextransucrase, B-512FMC dextransucrase, Cab3, CEP, DexT, dextran-sucrase, DS, DSase, DSR, Dsr S protein, DSR-F, DSR-S, DSRB742, DSRBCB4, DSRC39-2, DsrE563, DsrP, DSRS, DSRWC, DsrX, FT045B dextransucrase, glucansucrase, glucosyltransferase, glucosyltransferase, sucrose-1,6-alpha-glucan, glycosyltransferase R, Gtf, Gtf-DSM, GTFR, More, SGE, sucrose 6-glucosyltransferase, sucrose:1, 6-alpha-D-glucan 6-alpha-glucosyltransferase, sucrose:1,6-alpha-D-glucan-6-alpha-D-glucosyltransferase, Wc392-rDSR, WcCab3-DSR
ECTree
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General Information
General Information on EC 2.4.1.5 - dextransucrase
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evolution
metabolism
physiological function
additional information
dextransucrase belongs to the glycohydrolase family GH 70
evolution
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dextransucrases are glucansucrases belonging to the glycoside hydrolase family GH70
evolution
dextransucrases are glucansucrases belonging to the glycoside hydrolase family GH70
evolution
the enzyme belongs to the glycoside-hydrolase family GH70, transglucosidases that produce a-glucans from sucrose
evolution
sequence comparison with sequence alignment of Weissella confusa LBAE C39-2 dextransucrase and Lactobacillus reuteri 180, GTF180
evolution
sequence comparisons of enzyme DsrE563 and enzyme DsrE, the enzymes show differences in the sequence but similar properties
evolution
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sequence comparisons of the four conserved regions I, II, III and IV in the catalytic domains of different Lactobacillus dextransucrases
evolution
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sequence comparisons of the four conserved regions I, II, III and IV in the catalytic domains of different Lactobacillus dextransucrases
evolution
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sequence comparisons of the four conserved regions I, II, III and IV in the catalytic domains of different Lactobacillus dextransucrases
evolution
the enzyme belongs to the glycoside-hydrolase family 70, sequence and structural analysis of GH70 enzymes, overview
evolution
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sequence comparisons of enzyme DsrE563 and enzyme DsrE, the enzymes show differences in the sequence but similar properties
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evolution
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the enzyme belongs to the glycoside-hydrolase family 70, sequence and structural analysis of GH70 enzymes, overview
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evolution
Latilactobacillus curvatus TMW 1.624
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sequence comparisons of the four conserved regions I, II, III and IV in the catalytic domains of different Lactobacillus dextransucrases
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evolution
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sequence comparison with sequence alignment of Weissella confusa LBAE C39-2 dextransucrase and Lactobacillus reuteri 180, GTF180
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evolution
Limosilactobacillus reuteri TMW 1.106
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sequence comparisons of the four conserved regions I, II, III and IV in the catalytic domains of different Lactobacillus dextransucrases
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evolution
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dextransucrases are glucansucrases belonging to the glycoside hydrolase family GH70
-
evolution
-
dextransucrases are glucansucrases belonging to the glycoside hydrolase family GH70
-
evolution
-
the enzyme belongs to the glycoside-hydrolase family GH70, transglucosidases that produce a-glucans from sucrose
-
evolution
Ligilactobacillus animalis TMW 1.971
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sequence comparisons of the four conserved regions I, II, III and IV in the catalytic domains of different Lactobacillus dextransucrases
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growth and exopolysaccharide production correlated strongly for strain TMW 1.106
metabolism
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growth and exopolysaccharide production correlated strongly for strain TMW 1.624
metabolism
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growth and exopolysaccharide production correlated strongly for strain TMW 1.971
metabolism
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the enzyme is responsible for sucrose metabolism exhibiting both hydrolysis and glucosyl transferase activities
metabolism
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key enzyme in Streptococcus mutans for the metabolism of sucrose which helps in the adherence and accumulation of bacteria on tooth surface leading to the formation of dental caries
metabolism
Latilactobacillus curvatus TMW 1.624
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growth and exopolysaccharide production correlated strongly for strain TMW 1.624
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metabolism
Limosilactobacillus reuteri TMW 1.106
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growth and exopolysaccharide production correlated strongly for strain TMW 1.106
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metabolism
Ligilactobacillus animalis TMW 1.971
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growth and exopolysaccharide production correlated strongly for strain TMW 1.971
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metabolism
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the enzyme is responsible for sucrose metabolism exhibiting both hydrolysis and glucosyl transferase activities
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metabolism
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key enzyme in Streptococcus mutans for the metabolism of sucrose which helps in the adherence and accumulation of bacteria on tooth surface leading to the formation of dental caries
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in presence of sucrose, the strain B/110-1-2 produces two cell-associated dextransucrases (31.54% of the total glucosyltransferase activity) with molecular weights of 160 and 240 kDa and a soluble dextransucrase (68.46% of the total glucosyltransferase activity) at 160-180 kDa
physiological function
the dextransucrase is responsible for production of dextran with predominant alpha-(1->) linkages
physiological function
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Streptococcus mutans causes dental caries in humans using sucrose for its growth
physiological function
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the dextransucrase is responsible for production of dextran with predominant alpha-(1->) linkages
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physiological function
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in presence of sucrose, the strain B/110-1-2 produces two cell-associated dextransucrases (31.54% of the total glucosyltransferase activity) with molecular weights of 160 and 240 kDa and a soluble dextransucrase (68.46% of the total glucosyltransferase activity) at 160-180 kDa
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physiological function
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Streptococcus mutans causes dental caries in humans using sucrose for its growth
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amino acid residues D557, E595, and D667 are forming the catalytic triad
additional information
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amino acid residues D557, E595, and D667 are forming the catalytic triad
additional information
the amino acids involved in catalysis, E592, D554, D665 are conserved in the catalytic core
additional information
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the amino acids involved in catalysis, E592, D554, D665 are conserved in the catalytic core
additional information
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lactate is formed during production of exopolysaccharides
additional information
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lactate is formed during production of exopolysaccharides
additional information
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Lactobacillus animalis is a strong acidifier. The pH decreases fast to pH 3.75 and after 30 h fermentation, 167.14 mM lactate is formed during production of exopolysaccharides
additional information
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lactulosucrose can be an excellent candidate for an emerging bioactive oligosaccharide with potential pharmaceutical and food applications. Having lactulose as a core structure, lactulosucrose might possess the beneficial properties attributed to lactulose, such as the selective stimulation of beneficial bacteria in the large intestine and the regulation of intestinal transit time. Galacto-oligosaccharides derived from lactulose have enhanced functional properties as compared to galactooligosaccharides derived from lactose. Lactulosucrose can exert different or improved biological activities as compared to lactosucrose
additional information
one or more cysteine residues in the catalytic site are essential for enzyme activity
additional information
participation of Asp/Glu residues and His residues in both substrate binding and catalysis. The enzyme activity acidifies the reaction medium within 60 h
additional information
participation of Asp/Glu residues and His residues in both substrate binding and catalysis. The enzyme activity acidifies the reaction medium within 60 h
additional information
participation of Asp/Glu residues and His residues in both substrate binding and catalysis. The enzyme activity acidifies the reaction medium within 60 h
additional information
structure and size of in vitro dextran product is similar to dextran produced in vivo. Enzymatic production of dextran into wheat bran, overview
additional information
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structure and size of in vitro dextran product is similar to dextran produced in vivo. Enzymatic production of dextran into wheat bran, overview
additional information
structure modeling using the crystal structure of the enzyme from Lactobacillus reuteri, PDB ID 3HZ3, and Streptococcus mutans, PDB ID 3AlB, as templates. Asp510 acts as a nucleophile, Glu548 acts as catalytic acid/base, and Asp621 acts a stransition state stabilizer
additional information
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structure modeling using the crystal structure of the enzyme from Lactobacillus reuteri, PDB ID 3HZ3, and Streptococcus mutans, PDB ID 3AlB, as templates. Asp510 acts as a nucleophile, Glu548 acts as catalytic acid/base, and Asp621 acts a stransition state stabilizer
additional information
the glucan-binding domain is important for both enzyme expression and dextransucrase activity
additional information
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the glucan-binding domain is important for both enzyme expression and dextransucrase activity
additional information
three-dimensional enzyme molecular structure modeling, structure comparisons, overview. Role of peptide 460DYVHT464 in enzyme DSR-S linkage specificity, together with residue S512 it contributes to defining the +2 subsite topology, which may be critical for the enzyme regiospecificity. Molecular docking of sucrose in the active site of enzyme mutant DSR-S vardel DELTA4N
additional information
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the glucan-binding domain is important for both enzyme expression and dextransucrase activity
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additional information
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three-dimensional enzyme molecular structure modeling, structure comparisons, overview. Role of peptide 460DYVHT464 in enzyme DSR-S linkage specificity, together with residue S512 it contributes to defining the +2 subsite topology, which may be critical for the enzyme regiospecificity. Molecular docking of sucrose in the active site of enzyme mutant DSR-S vardel DELTA4N
-
additional information
Latilactobacillus curvatus TMW 1.624
-
lactate is formed during production of exopolysaccharides
-
additional information
-
participation of Asp/Glu residues and His residues in both substrate binding and catalysis. The enzyme activity acidifies the reaction medium within 60 h
-
additional information
-
structure and size of in vitro dextran product is similar to dextran produced in vivo. Enzymatic production of dextran into wheat bran, overview
-
additional information
Limosilactobacillus reuteri TMW 1.106
-
lactate is formed during production of exopolysaccharides
-
additional information
-
lactulosucrose can be an excellent candidate for an emerging bioactive oligosaccharide with potential pharmaceutical and food applications. Having lactulose as a core structure, lactulosucrose might possess the beneficial properties attributed to lactulose, such as the selective stimulation of beneficial bacteria in the large intestine and the regulation of intestinal transit time. Galacto-oligosaccharides derived from lactulose have enhanced functional properties as compared to galactooligosaccharides derived from lactose. Lactulosucrose can exert different or improved biological activities as compared to lactosucrose
-
additional information
-
the amino acids involved in catalysis, E592, D554, D665 are conserved in the catalytic core
-
additional information
-
amino acid residues D557, E595, and D667 are forming the catalytic triad
-
additional information
-
one or more cysteine residues in the catalytic site are essential for enzyme activity
-
additional information
Ligilactobacillus animalis TMW 1.971
-
Lactobacillus animalis is a strong acidifier. The pH decreases fast to pH 3.75 and after 30 h fermentation, 167.14 mM lactate is formed during production of exopolysaccharides
-