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2.1.1.68: caffeate O-methyltransferase

This is an abbreviated version!
For detailed information about caffeate O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.68

Reaction

S-adenosyl-L-methionine
+
3,4-dihydroxy-trans-cinnamate
=
S-adenosyl-L-homocysteine
+
3-methoxy-4-hydroxy-trans-cinnamate

Synonyms

3,4-dihydroxybenzaldehyde-O-methyltransferase, AtCOMT1, AtOMT1, benzenoid/phenylpropanoid meta/para-O-methyltransferase, Bmr12, Bradi3g16530, brown midrib 12, caffeate 3-O-methyltransferase, caffeate methyltransferase, caffeate/5-hydroxyferulate 3/5-O-methyltransferase, caffeic acid 3-O-methyltransferase, caffeic acid O-methyl-transferase, caffeic acid O-methyltransferase, caffeic acid O-methyltransferase 1, caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase, caffeic O-methyl transferase, CCOMT, COMT, COMT-3D, COMT1, COMT2, COMT4, COMT6, DOMT, FGCOMT1, Lp OMT1, O-methyltransferase, O-methytransferase, OMT, OMT1, OMT3, OsCOMT1, RsOMT1, RsOMT3, S-adenosyl-L-methionine:caffeic acid-O-methyltransferase, Sb07g003860, Van OMT-2, Van OMT-3

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.68 caffeate O-methyltransferase

Reference

Reference on EC 2.1.1.68 - caffeate O-methyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Day, A.; Dehorter, B.; Neutelings, G.; Czeszak, X.; Chabbert, B.; Belingheri, L.; David, H.
Caffeoyl-coenzyme A 3-O-methyltransferase enzyme activity, protein and transcript accumulation in flax (Linum usitatissimum) stem during development
Physiol. Plant.
113
275-284
2001
Linum usitatissimum
Manually annotated by BRENDA team
Parvathi, K.; Chen, F.; Guo, D.; Blount, J.W.; Dixon, R.A.
Substrate preferences of O-methyltransferases in alfalfa suggest new pathways for 3-O-methylation of monolignols
Plant J.
25
193-202
2001
Medicago sativa
Manually annotated by BRENDA team
Grimmig, B.; Kneusel, R.E.; Junghanns, K.T.; Matern, U.
Expression of bifunctional caffeoyl-CoA 3-O-methyltransferase in stress compensation and lignification
Plant Biol.
1
299-310
1999
Petroselinum crispum
-
Manually annotated by BRENDA team
Martz, F.; Maury, S.; Pincon, G.; Legrand, M.
cDNA cloning, substrate specificity and expression study of tobacco caffeoyl-CoA 3-O-methyltransferase, a lignin biosynthetic enzyme
Plant Mol. Biol.
36
427-437
1998
Nicotiana tabacum
Manually annotated by BRENDA team
Meng, H.; Campbell, W.H.
Substrate profiles and expression of caffeoyl coenzyme A and caffeic acid O-methyltransferases in secondary xylem of aspen during seasonal development
Plant Mol. Biol.
38
513-520
1998
Populus tremuloides
Manually annotated by BRENDA team
Eckardt, N.A.
Probing the mysteries of lignin biosynthesis: The crystal structure of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase provides new insights
Plant Cell
14
1185-1189
2002
Medicago sativa
Manually annotated by BRENDA team
Zubieta, C.; Kota, P.; Ferrer, J.L.; Dixon, R.A.; Noel, J.P.
Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase
Plant Cell
14
1265-1277
2002
Medicago sativa (P28002), Medicago sativa
Manually annotated by BRENDA team
Xue, Z.T.; Brodelius, P.E.
Kinetin-induced caffeic acid O-methyltransferases in cell suspension cultures of Vanilla planifolia Andr. and isolation of caffeic acid O-methyltransferase cDNAs
Plant Physiol. Biochem.
36
779-788
1998
Vanilla planifolia
-
Manually annotated by BRENDA team
Bugos, R.C.; Chiang, V.L.C.; Campbell, W.H.
Characterization of bispecific caffeic acid/5-hydroxyferulic acid O-methyltransferase from aspen
Phytochemistry
31
1495-1498
1992
Populus tremuloides
Manually annotated by BRENDA team
Ye, Z.H.; Zhong, R.; Morrison, W.H.; Himmelsbach, D.S.
Caffeoyl coenzyme A O-methyltransferase and lignin biosynthesis
Phytochemistry
57
1177-1185
2001
Magnoliopsida, Nicotiana tabacum, Populus tremuloides
Manually annotated by BRENDA team
Bugos, R.C.; Chiang, V.L.C.; Campbell, W.H.
cDNA cloning, sequence analysis and seasonal expression of lignin-bispecific caffeic acid/5-hydroxyferulic acid O-methyltransferase of aspen
Plant Mol. Biol.
17
1203-1215
1991
Populus tremuloides
Manually annotated by BRENDA team
Edwards, R.; Dixon, R.A.
Purification and characterization of S-adenosyl-L-methionine: caffeic acid 3-O-methyltransferase from suspension cultures of alfalfa (Medicago sativa L.)
Arch. Biochem. Biophys.
287
372-379
1991
Medicago sativa
Manually annotated by BRENDA team
Vance, C.P.; Bryan, J.W.
Purification and properties of caffeic acid O-methyltransferase from alfalfa root nodules
Phytochemistry
20
41-43
1981
Medicago sativa, Medicago sativa Saranac
-
Manually annotated by BRENDA team
Collendavelloo, J.; Legrand, M.; Geoffroy, P.; Barthelemy, J.; Fritig, B.
Purification and properties of the three o-diphenol-O-methyltransferases of tobacco leaves
Phytochemistry
20
611-616
1981
Nicotiana tabacum
-
Manually annotated by BRENDA team
Sugano, N.; Ogawa, Y.
Effect of 2,4-dichlorophenoxyacetic acid on the activity of O-methyltransferase in carrot cell culture
Phytochemistry
20
617-619
1981
Daucus carota
-
Manually annotated by BRENDA team
Poulton, J.E.; Hahlbrock, K.; Grisebach, H.
Enzymic synthesis of lignin precursors. Purification of properties of the S-adenosyl-l-methionine: caffeic acid 3-O-methyltransferase from soybean cell suspension cultures
Arch. Biochem. Biophys.
176
449-456
1976
Glycine max
Manually annotated by BRENDA team
Poulton, J.E.; Butt, V.S.
Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L)
Biochim. Biophys. Acta
403
301-314
1975
Beta vulgaris, Phaseolus vulgaris, Pisum sativum, Spinacia oleracea
Manually annotated by BRENDA team
Shimada, M.; Kuroda, H.; Higuchi, T.
Evidence for the formation of methoxyl groups of ferulic acid and sinapic acids in Bambusa by the same O-methyltransferase
Phytochemistry
12
2873-2875
1973
Bambusa sp.
-
Manually annotated by BRENDA team
Ruelland, E.; Campalans, A.; Selman-Housein, G.; Puigdomenech, P.; Rigau, J.
Cellular and subcellular localization of the lignin biosynthetic enzymes caffeic acid-O-methyltransferase, cinnamyl alcohol dehydrogenase and cinnamoyl-coenzyme A reductase in two monocots, sugarcane and maize
Physiol. Plant.
117
93-99
2003
Saccharum officinarum, Zea mays
-
Manually annotated by BRENDA team
Chen, L.; Auh, C.K.; Dowling, P.; Bell, J.; Lehmann, D.; Wang, Z.Y.
Transgenic down-regulation of caffeic acid O-methyltransferase (COMT) led to improved digestibility in tall fescue (Festuca arundinacea)
Funct. Plant Biol.
31
235-245
2004
Lolium arundinaceum
Manually annotated by BRENDA team
Kota, P.; Guo, D.; Zubieta, C.; Noel, J.; Dixon, R.A.
O-Methylation of benzaldehyde derivatives by "lignin specific" caffeic acid 3-O-methyltransferase
Phytochemistry
65
837-846
2004
Medicago sativa
Manually annotated by BRENDA team
Vincent, D.; Lapierre, C.; Pollet, B.; Cornic, G.; Negroni, L.; Zivy, M.
Water deficits affect caffeate O-methyltransferase, lignification, and related enzymes in maize leaves. A proteomic investigation
Plant Physiol.
137
949-960
2005
Zea mays
Manually annotated by BRENDA team
Lin, F.; Yamano, G.; Hasegawa, M.; Anzai, H.; Kawasaki, S.; Kodama, O.
Cloning and functional analysis of caffeic acid 3-O-methyltransferase from rice (Oryza sativa)
J. Pestic. Sci.
31
47-53
2006
Oryza sativa
-
Manually annotated by BRENDA team
Li, H.M.; Rotter, D.; Hartman, T.G.; Pak, F.E.; Havkin-Frenkel, D.; Belanger, F.C.
Evolution of novel O-methyltransferases from the Vanilla planifolia caffeic acid O-methyltransferase
Plant Mol. Biol.
61
537-552
2006
Vanilla pompona, Vanilla planifolia (Q27I62), Vanilla planifolia (Q27I63), Vanilla planifolia
Manually annotated by BRENDA team
Fornale, S.; Sonbol, F.M.; Maes, T.; Capellades, M.; Puigdomenech, P.; Rigau, J.; Caparros-Ruiz, D.
Down-regulation of the maize and Arabidopsis thaliana caffeic acid O-methyl-transferase genes by two new maize R2R3-MYB transcription factors
Plant Mol. Biol.
62
809-823
2006
Arabidopsis thaliana, Zea mays
Manually annotated by BRENDA team
Bhuiya, M.W.; Liu, C.J.
A cost-effective colorimetric assay for phenolic O-methyltransferases and characterization of caffeate 3-O-methyltransferases from Populus trichocarpa
Anal. Biochem.
384
151-158
2009
Populus trichocarpa (A9P830), Populus trichocarpa (C6FFB6)
Manually annotated by BRENDA team
Ma, Q.; Xu, Y.
Characterization of a caffeic acid 3-O-methyltransferase from wheat and its function in lignin biosynthesis
Biochimie
90
515-524
2008
Triticum aestivum (Q38J50)
Manually annotated by BRENDA team
Guillaumie, S.; Goffner, D.; Barbier, O.; Martinant, J.P.; Pichon, M.; Barriere, Y.
Expression of cell wall related genes in basal and ear internodes of silking brown-midrib-3, caffeic acid O-methyltransferase (COMT) down-regulated, and normal maize plants
BMC Plant Biol.
8
71
2008
Zea mays (Q06509), Zea mays
Manually annotated by BRENDA team
Ma, Q.H.
The expression of caffeic acid 3-O-methyltransferase in two wheat genotypes differing in lodging resistance
J. Exp. Bot.
60
2763-2771
2009
Triticum aestivum (Q38J50)
Manually annotated by BRENDA team
Pak, F.E.; Gropper, S.; Dai, W.D.; Havkin-Frenkel, D.; Belanger, F.C.
Characterization of a multifunctional methyltransferase from the orchid Vanilla planifolia
Plant Cell Rep.
22
959-966
2004
Vanilla planifolia (Q6Q796), Vanilla planifolia
Manually annotated by BRENDA team
Qin, J.C.; Zhang, Y.M.; Lang, C.Y.; Yao, Y.H.; Pan, H.Y.; Li, X.
Cloning and functional characterization of a caffeic acid O-methyltransferase from Trigonella foenum-graecum L
Mol. Biol. Rep.
39
1601-1608
2012
Trigonella foenum-graecum
Manually annotated by BRENDA team
Moinuddin, S.G.; Jourdes, M.; Laskar, D.D.; Ki, C.; Cardenas, C.L.; Kim, K.W.; Zhang, D.; Davin, L.B.; Lewis, N.G.
Insights into lignin primary structure and deconstruction from Arabidopsis thaliana COMT (caffeic acid O-methyl transferase) mutant Atomt1
Org. Biomol. Chem.
8
3928-3946
2010
Arabidopsis thaliana
Manually annotated by BRENDA team
Tu, Y.; Rochfort, S.; Liu, Z.; Ran, Y.; Griffith, M.; Badenhorst, P.; Louie, G.V.; Bowman, M.E.; Smith, K.F.; Noel, J.P.; Mouradov, A.; Spangenberg, G.
Functional analyses of caffeic acid O-methyltransferase and cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne)
Plant Cell
22
3357-3373
2010
Lolium perenne
Manually annotated by BRENDA team
Louie, G.V.; Bowman, M.E.; Tu, Y.; Mouradov, A.; Spangenberg, G.; Noel, J.P.
Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference
Plant Cell
22
4114-4127
2010
Lolium perenne
Manually annotated by BRENDA team
Fellenberg, C.; van Ohlen, M.; Handrick, V.; Vogt, T.
The role of CCoAOMT1 and COMT1 in Arabidopsis anthers
Planta
236
51-61
2012
Arabidopsis thaliana
Manually annotated by BRENDA team
Sattler, S.; Palmer, N.; Saballos, A.; Greene, A.; Xin, Z.; Sarath, G.; Vermerris, W.; Pedersen, J.
Identification and characterization of four missense mutations in brown midrib 12 (Bmr12), the caffeic O-methyltranferase (COMT) of sorghum
Bioenergy Res.
5
855-865
2012
Sorghum bicolor (C5YH12)
-
Manually annotated by BRENDA team
Naaz, H.; Pandey, V.P.; Singh, S.; Dwivedi, U.N.
Structure-function analyses and molecular modeling of caffeic acid-O-methyltransferase and caffeoyl-CoA-O-methyltransferase: revisiting the basis of alternate methylation pathways during monolignol biosynthesis
Biotechnol. Appl. Biochem.
60
170-189
2013
Medicago sativa (P28002)
Manually annotated by BRENDA team
Li, J.J.; Zhang, G.; Yu, J.H.; Li, Y.Y.; Huang, X.H.; Wang, W.J.; Tan, R.; Zhou, J.Y.; Liao, H.
Molecular cloning and characterization of caffeic acid 3-O-methyltransferase from the rhizome of Ligusticum chuanxiong
Biotechnol. Lett.
37
2295-2302
2015
Ligusticum sinense (A0A0K1YW34)
Manually annotated by BRENDA team
Trabucco, G.M.; Matos, D.A.; Lee, S.J.; Saathoff, A.J.; Priest, H.D.; Mockler, T.C.; Sarath, G.; Hazen, S.P.
Functional characterization of cinnamyl alcohol dehydrogenase and caffeic acid O-methyltransferase in Brachypodium distachyon
BMC Biotechnol.
13
61
2013
Brachypodium distachyon (I1I1F5), Brachypodium distachyon
Manually annotated by BRENDA team
Ho-Yue-Kuang, S.; Alvarado, C.; Antelme, S.; Bouchet, B.; Cezard, L.; Le Bris, P.; Legee, F.; Maia-Grondard, A.; Yoshinaga, A.; Saulnier, L.; Guillon, F.; Sibout, R.; Lapierre, C.; Chateigner-Boutin, A.L.
Mutation in Brachypodium caffeic acid O-methyltransferase 6 alters stem and grain lignins and improves straw saccharification without deteriorating grain quality
J. Exp. Bot.
67
227-237
2015
Brachypodium distachyon
Manually annotated by BRENDA team
Dwivedi, U.; Gupta, P.; Pandey, V.; Singh, S.; Singh, R.
Caffeic acid O-methyltransferase from Leucaena leucocephala: Cloning, expression, characterization and molecular docking analyses
J. Mol. Catal. B
106
63-70
2014
Leucaena leucocephala (A7U0E5)
-
Manually annotated by BRENDA team
Byeon, Y.; Lee, H.Y.; Lee, K.; Back, K.
Caffeic acid O-methyltransferase is involved in the synthesis of melatonin by methylating N-acetylserotonin in Arabidopsis
J. Pineal Res.
57
219-227
2014
Arabidopsis thaliana (Q9FK25), Arabidopsis thaliana
Manually annotated by BRENDA team
Kim, J.; Choi, B.; Cho, B.; Lim, H.; Kim, J.; Natarajan, S.; Kwak, E.; Bae, H.
Molecular cloning, characterization and expression of the caffeic acid O-methyltransferase (COMT) ortholog from kenaf (Hibiscus cannabinus)
Plant OMICS
6
246-253
2013
Hibiscus cannabinus (A0A088B191)
-
Manually annotated by BRENDA team
Green, A.R.; Lewis, K.M.; Barr, J.T.; Jones, J.P.; Lu, F.; Ralph, J.; Vermerris, W.; Sattler, S.E.; Kang, C.
Determination of the structure and catalytic mechanism of Sorghum bicolor caffeic acid O-methyltransferase and the structural impact of three brown midrib12 mutations
Plant Physiol.
165
1440-1456
2014
Sorghum bicolor (C5YH12), Sorghum bicolor
Manually annotated by BRENDA team
Byeon, Y.; Back, K.
Melatonin production in Escherichia coli by dual expression of serotonin N-acetyltransferase and caffeic acid O-methyltransferase
Appl. Microbiol. Biotechnol.
100
6683-6691
2016
Oryza sativa Japonica Group (Q6ZD89)
Manually annotated by BRENDA team
Wang, W.; Su, S.; Wang, S.; Ye, L.; Yu, H.
Significantly improved catalytic efficiency of caffeic acid O-methyltransferase towards N-acetylserotonin by strengthening its interactions with the unnatural substrates terminal structure
Enzyme Microb. Technol.
125
1-5
2019
Arabidopsis thaliana (Q9FK25), Arabidopsis thaliana
Manually annotated by BRENDA team
Byeon, Y.; Choi, G.H.; Lee, H.Y.; Back, K.
Melatonin biosynthesis requires N-acetylserotonin methyltransferase activity of caffeic acid O-methyltransferase in rice
J. Exp. Bot.
66
6917-6925
2015
Oryza sativa (Q6ZD89), Oryza sativa
Manually annotated by BRENDA team
Choi, G.H.; Lee, H.Y.; Back, K.
Chloroplast overexpression of rice caffeic acid O-methyltransferase increases melatonin production in chloroplasts via the 5-methoxytryptamine pathway in transgenic rice plants
J. Pineal Res.
63
e12412
2017
Oryza sativa
Manually annotated by BRENDA team
Sun, S.; Wen, D.; Yang, W.; Meng, Q.; Shi, Q.; Gong, B.
Overexpression of caffeic acid O-methyltransferase 1 (COMT1) increases melatonin level and salt stress tolerance in tomato plant
J. Plant Growth Regul.
39
1221-1235
2020
Solanum lycopersicum
-
Manually annotated by BRENDA team
Wiens, B.; De Luca, V.
Molecular and biochemical characterization of a benzenoid/phenylpropanoid meta/para-O-methyltransferase from Rauwolfia serpentina roots
Phytochemistry
132
5-15
2016
Rauvolfia serpentina (A0A1I9RGJ4), Rauvolfia serpentina (A0A1I9RGJ6)
Manually annotated by BRENDA team
Jung, J.H.; Altpeter, F.
TALEN mediated targeted mutagenesis of the caffeic acid O-methyltransferase in highly polyploid sugarcane improves cell wall composition for production of bioethanol
Plant Mol. Biol.
92
131-142
2016
Saccharum officinarum (O82054), Saccharum officinarum
Manually annotated by BRENDA team
Wang, M.; Zhu, X.; Wang, K.; Lu, C.; Luo, M.; Shan, T.; Zhang, Z.
A wheat caffeic acid 3-O-methyltransferase TaCOMT-3D positively contributes to both resistance to sharp eyespot disease and stem mechanical strength
Sci. Rep.
8
6543
2018
Triticum aestivum
Manually annotated by BRENDA team
Kasirajan, L.; Aruchamy, K.
Molecular cloning of cDNA from sugarcane coding for caffeic acid O-methyltransferase (COMT) involved in lignification
Sugar Tech.
18
553-556
2016
Saccharum officinarum
-
Manually annotated by BRENDA team