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2.1.1.34: tRNA (guanosine18-2'-O)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (guanosine18-2'-O)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.34

Reaction

S-adenosyl-L-methionine
+
guanosine18 in tRNA
=
S-adenosyl-L-homocysteine
 +
2'-O-methylguanosine18 in tRNA

Synonyms

methyltransferase, transfer ribonucleate guanosine 2'-, S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase, SpoU, TARBP1, transfer ribonucleate guanosine 2'-methyltransferase, transfer RNA (Gm18) methyltransferase, TrmH, tRNA (Gm18) 2'-O-methyltransferase, tRNA (Gm18) methyltransferase, tRNA (guanosine-2'-O-)-methyltransferase, tRNA Gm18 methyltransferase, tRNA guanosine 2'-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.34 tRNA (guanosine18-2'-O)-methyltransferase

Activating Compound

Activating Compound on EC 2.1.1.34 - tRNA (guanosine18-2'-O)-methyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
caldohexamine
1 mM caldohexamine increases TrmH activity at 60-80°C. No positive effect on the TrmH activity at 55°C
Polyamine
higher concentrations of linear polyamines inhibit TrmH activity at 55°C, while optimum concentration increases TrmH activity at 45-75°C
-
S-adenosyl-L-methionine
-
enhances the affinity for tRNA and induces formation of the tetramer structure
spermine
-
activation, 5 mM
tetrakis(3-aminopropyl)ammonium
0.25 mM, increases TrmH activity at 40-85°C