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2.1.1.33: tRNA (guanine46-N7)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (guanine46-N7)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.33

Reaction

S-adenosyl-L-methionine
+
guanine46 in tRNA
=
S-adenosyl-L-homocysteine
+
N7-methylguanine46 in tRNA

Synonyms

7-methylguanine transfer ribonucleate methylase, m7G-methyltransferase, m7G46 methyltransferase Trm8p/Trm82p, methyltransferase like 1, methyltransferase, transfer ribonucleate guanine 7-, METTL1, N7-methylguanine methylase, PA14_05000, transfer ribonucleate guanine 7-methyltransferase, transfer RNA (m7G46) methyltransferase, Trm8–Trm82 complex, TrmB, TrMet (m7G46), tRNA (m7G46) methyltransferase, tRNA guanine 7-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.33 tRNA (guanine46-N7)-methyltransferase

General Information

General Information on EC 2.1.1.33 - tRNA (guanine46-N7)-methyltransferase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
nonessential tRNA modifications by methyltransferases are evolutionarily conserved and have been reported to stabilize mature tRNA molecules and prevent rapid tRNA decay. The tRNA modifying enzymes, NSUN2 and METTL1, are mammalian orthologues of yeast Trm4 and Trm8, which are required for protecting tRNA against tRNA decay
malfunction
physiological function