2.1.1.33: tRNA (guanine46-N7)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (guanine46-N7)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.33
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2.1.1.33
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methyltransferase-like
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n7-methylguanosine
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cyp27b1
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mettl21b
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trnaphe
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mescs
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kidney-specific
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methylome
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submodules
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methyl-transfer
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pharmacology
- 2.1.1.33
-
methyltransferase-like
-
n7-methylguanosine
- cyp27b1
-
mettl21b
- trnaphe
-
mescs
-
kidney-specific
-
methylome
-
submodules
-
methyl-transfer
- pharmacology
Reaction
Synonyms
7-methylguanine transfer ribonucleate methylase, m7G-methyltransferase, m7G46 methyltransferase Trm8p/Trm82p, methyltransferase like 1, methyltransferase, transfer ribonucleate guanine 7-, METTL1, N7-methylguanine methylase, PA14_05000, transfer ribonucleate guanine 7-methyltransferase, transfer RNA (m7G46) methyltransferase, Trm8–Trm82 complex, TrmB, TrMet (m7G46), tRNA (m7G46) methyltransferase, tRNA guanine 7-methyltransferase
ECTree
2.1.1.33 tRNA (guanine46-N7)-methyltransferaseAdvanced search results
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results (Engineering
Engineering on EC 2.1.1.33 - tRNA (guanine46-N7)-methyltransferase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Glu202Stop
is unstable to heat treatment as compared to the full-length wild-type enzyme, but has an enzymatic activity
additional information
additional information
mutant strain, trmB gene inactivated by an insertion, shows normal growth
additional information
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mutant strain, trmB gene inactivated by an insertion, shows normal growth
additional information
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combined knockdown of NSUN2, EC 2.1.1.203, and METTL1 in HeLa cells
additional information
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strains lacking either Trm8 or Trm82 yield extracts with no detectable enzyme activity, and have severely reduced m7G-modified tRNA in vivo
additional information
Q03774; Q12009
strains lacking Trm8p/Trm82p tRNA m7G methyltransferase, are temperature-sensitive in synthetic media containing glycerol, trm82-delta strain shows reduced levels of Trm8p, but not of its mRNA, the growth phenotype of trm8 mutants correlates with lack of tRNA m7G methyltransferase activity in vitro and in vivo, bacterial Trm8p orthologs complement the trm8-delta trm82-delta growth phenotype and restore m7G-methyltransferase activity in vitro and in vivo
