2.1.1.17: phosphatidylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphatidylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.17
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2.1.1.17
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phosphatidylcholine
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choline
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homocysteine
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cytidylyltransferase
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cdp-choline
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betaine
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s-adenosylhomocysteine
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ctp:phosphocholine
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cdp-diacylglycerol
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phosphatidyl-n,n-dimethylethanolamine
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phosphatidyl-n-monomethylethanolamine
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choline-deficient
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transmethylation
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n-methyltransferases
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kennedy
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adomet
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vance
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phosphatidylmonomethylethanolamine
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medicine
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ptdcho
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analysis
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phosphatidyldimethylethanolamine
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mthfd1
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remethylation
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cholinephosphotransferase
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adohcy
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choline-supplemented
- 2.1.1.17
- phosphatidylcholine
- choline
- homocysteine
- cytidylyltransferase
- cdp-choline
- betaine
- s-adenosylhomocysteine
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ctp:phosphocholine
- cdp-diacylglycerol
- phosphatidyl-n,n-dimethylethanolamine
- phosphatidyl-n-monomethylethanolamine
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choline-deficient
-
transmethylation
- n-methyltransferases
-
kennedy
- adomet
-
vance
- phosphatidylmonomethylethanolamine
- medicine
-
ptdcho
- analysis
- phosphatidyldimethylethanolamine
- mthfd1
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remethylation
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cholinephosphotransferase
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adohcy
-
choline-supplemented
Reaction
Synonyms
lipid methyl transferase, LMTase, methyltransferase, phosphatidylethanolamine, PE N-MTase, PE-NMT, PEMT, PEMT shorter isoform, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine-N-methylase, phosphatidylethanolamine-N-methyltransferase, phosphatidylethanolamine-S-adenosylmethionine methyltransferase, phospholipid N-methyltransferase, PmtA, PmtX1, PmtX3
ECTree
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Source Tissue
Source Tissue on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
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phosphatidylethanolamine N-methyltransferase assays demonstrate salinity-dependent activities in the digestive gland and hemocytes
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phosphatidylethanolamine N-methyltransferase assays demonstrate salinity-dependent activities in the digestive gland and hemocytes
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a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimers disease
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high level of activity is expressed in defined extranuclear regions
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enzyme form PEMT2 is absent in hepatoma cells growing exponentially in vivo. Both PEMT2 and mRNA appears when cells enter the stationary phase of tumor growth
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PEMT2 protein decreases in preneoplastic nodules and virtually disappears in hepatocellular carcinoma
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485164, 485165, 485167, 485168, 485169, 485170, 485171, 485174, 485179, 485184, 485186, 485188, 485189, 485191, 485192, 485195, 675185
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in prenatal livers enzyme form PEMT2 is completely absent, high level of PEMT2 appears at birth and is sustained throughout adult life
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normal liver, nodules, advanced nodules and hepatomas. Enzyme form PEMT2 is diminished during liver carcinogenesis
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ovary cell line MT58, with impaired CDP-choline pathway caused by a temperature-sensitive mutation in CTP:phosphocholine cytidyltransferase. PEMT2 expression fails to rescue the mutant cell line at 40°C because it does not maintain phosphatidylcholine levels required for cellular replication
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cells express only a trace amount of phosphatidylethanolamine N-methyltransferase. Transfection of CHO cells, ovary cell line MT58, with PEMT2 cDNA behind the cytomegalovirus promoter result in a series of cell lines that overexpress PEMT2