2.1.1.104: caffeoyl-CoA O-methyltransferase
This is an abbreviated version!
For detailed information about caffeoyl-CoA O-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.104
-
2.1.1.104
-
lignin
-
flavonoid
-
o-methylation
-
phenylpropanoids
-
polyketide
-
xylem
-
monolignols
-
ferulic
-
lignification
-
syringyl
-
poplar
-
guaiacyl
-
ammonia-lyase
-
sam-dependent
-
s-adenosyl-l-homocysteine
-
s-adenosyl-l-methionine-dependent
-
cinnamyl
-
coniferyl
-
5-hydroxylase
-
allata
-
d-aspartyl
-
s-adenosylmethionine-dependent
-
4-coumarate
-
l-isoaspartyl
-
feruloyl
-
feruloyl-coa
-
sinapyl
-
aspen
-
orcinol
-
4-coumarate:coa
-
2.1.1.6
-
cinnamoyl-coa
-
hydroxycinnamoyl
-
medicine
-
agriculture
-
analysis
- 2.1.1.104
- lignin
- flavonoid
-
o-methylation
-
phenylpropanoids
- polyketide
- xylem
- monolignols
-
ferulic
-
lignification
-
syringyl
- poplar
-
guaiacyl
-
ammonia-lyase
-
sam-dependent
- s-adenosyl-l-homocysteine
-
s-adenosyl-l-methionine-dependent
-
cinnamyl
-
coniferyl
-
5-hydroxylase
- allata
-
d-aspartyl
-
s-adenosylmethionine-dependent
- 4-coumarate
-
l-isoaspartyl
-
feruloyl
- feruloyl-coa
-
sinapyl
- aspen
- orcinol
-
4-coumarate:coa
-
2.1.1.6
- cinnamoyl-coa
-
hydroxycinnamoyl
- medicine
- agriculture
- analysis
Reaction
Synonyms
ASCCoAOMT, At4g26220, caffeic acid 3-O-methyltransferase, caffeoyl CoA 3-O-methyltransferase, caffeoyl CoA methyltransferase, caffeoyl CoA methyltransferase 7, caffeoyl CoA O-methyltransferase, caffeoyl CoA-O-methyltransferase, caffeoyl coenzyme A 3-O-methyltransferase, caffeoyl coenzyme A methyltransferase, caffeoyl coenzyme A O-methyltransferase, caffeoyl-CoA 3-O-methyltransferase, caffeoyl-CoA-O-methyl transferase 1, caffeoyl-CoA-O-methyl transferase 2, caffeoyl-coenzyme A 3-o-methyltransferase, caffeoyl-coenzyme A O-methyltransferase, CCoAMT, CCoAOMT, CCoAOMT 1, CCoAOMT 2, CCoAOMT-1, CCoAOMT-like, CCoAOMT1, CCoAOMT2, CCoAOMT7, CCOMT, COMT, F6OMT, hi12, More, O-methyltransferase, OMT-15, OMT-17, OMT1, S-adenosyl-L-methionine:trans-caffeoyl-CoA 3-O-methyltransferase, TaCCoAOMT1, trans-caffeoyl-CoA 3-O-methyltransferase, Vp-OMT4, Vp-OMT5
ECTree
2.1.1.104 caffeoyl-CoA O-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.104 - caffeoyl-CoA O-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 3,4-dihydroxybenzaldehyde
?
moderate activity
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxybenzoic acid
S-adenosyl-L-homocysteine + ?
-
activity in presence of Co2+, no activity in presence of Mg2+
-
-
?
S-adenosyl-L-methionine + 4-coumaroyl-CoA
S-adenosyl-L-homocysteine + ?
-
very low activity
-
-
?
S-adenosyl-L-methionine + 5-hydroxy-ferulic acid
S-adenosyl-L-homocysteine + ?
-
activity in presence of Co2+, no activity in presence of Mg2+
-
-
?
S-adenosyl-L-methionine + 5-hydroxyconiferaldehyde
S-adenosyl-L-homocysteine + sinapaldehyde
S-adenosyl-L-methionine + 5-hydroxyferulic acid
S-adenosyl-L-homocysteine + sinapic acid
-
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferulic acid ethyl ester
?
high activity
-
-
?
S-adenosyl-L-methionine + 7,8-dihydroxyflavone
?
-
OMT-15 shows 102% activity and OMT-17 shows 143% activity compared to myricetin
-
-
?
S-adenosyl-L-methionine + caffeoyl alcohol
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + caffeoyl alcohol
S-adenosyl-L-homocysteine + coniferyl alcohol
-
-
-
?
S-adenosyl-L-methionine + caffeoyl aldehyde
S-adenosyl-L-homocysteine + coniferaldehyde
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + ?
-
OMT-15 shows 100% activity and OMT-17 shows 58% activity compared to myricetin
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl CoA
33% of the activity with luteolin
-
-
?
S-adenosyl-L-methionine + caffeoyl-D-glucose
S-adenosyl-L-homocysteine + feruloyl-D-glucose
-
-
-
-
?
S-adenosyl-L-methionine + caffeoylaldehyde
?
low activity
-
-
?
S-adenosyl-L-methionine + coniferaldehyde
S-adenosyl-L-homocysteine + sinapaldehyde
-
-
-
?
S-adenosyl-L-methionine + coniferyl alcohol
S-adenosyl-L-homocysteine + sinapyl alcohol
-
-
-
?
S-adenosyl-L-methionine + cyanidin 3-O-glucoside
S-adenosyl-L-homocysteine + peonidin 3-O-glucoside
-
-
-
?
S-adenosyl-L-methionine + dihydroquercetin
S-adenosyl-L-homocysteine + ?
2.5% of the activity with luteolin
-
-
?
S-adenosyl-L-methionine + epigallocatechin-3-O-gallate
S-adenosyl-L-homocysteine + ?
-
-
methylation occurs in 3'-, 3''- and 4''-position
-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + eriodictoyl-3'-O-methylether + eriodictoyl-4'-O-methylether
15% of the activity with luteolin
80% para product versus 20% meta in the wild type
-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + homoeriodictyol
-
single product
-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + homoeriodictyol + hesperetin
-
-
-
?
S-adenosyl-L-methionine + esculetin
S-adenosyl-L-homocysteine + scopoletin
-
-
-
?
S-adenosyl-L-methionine + ferulic acid
S-adenosyl-L-homocysteine + sinapic acid
-
-
-
?
S-adenosyl-L-methionine + feruloyl-CoA
S-adenosyl-L-homocysteine + ?
-
very low activity
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + chrysoeriol
-
-
-
?
S-adenosyl-L-methionine + quercetagetin
S-adenosyl-L-homocysteine + ?
-
no activity in presence of Co2+, low activity in presence of Mg2+
-
-
?
S-adenosyl-L-methionine + quercetagetin
S-adenosyl-L-homocysteine + quercetagetin 6,3'-di-O-methylether
-
-
-
?
S-adenosyl-L-methionine + sinapoyl-CoA
S-adenosyl-L-homocysteine + ?
-
low activity
-
-
?
S-adenosyl-L-methionine + trans-caffeic acid esters
S-adenosyl-L-homocysteine + ?
-
such as methyl caffeate, chlorogenic acid, trans-5-O-caffeoylshikimate, rosmarinic acid, poor substrates
-
-
?
S-adenosyl-L-methionine + tricetin
S-adenosyl-L-homocysteine + selgin
highest activity
tricin, also identified as product
-
?
S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
3' methylating activity
-
-
?
S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
56% activity compared to caffeoyl-CoA
-
-
?
S-adenosyl-L-methionine + 5-hydroxyconiferaldehyde
?
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyconiferaldehyde
?
low activity
-
-
?
S-adenosyl-L-methionine + 5-hydroxyconiferaldehyde
?
moderate activity
-
-
?
S-adenosyl-L-methionine + 5-hydroxyconiferaldehyde
S-adenosyl-L-homocysteine + sinapaldehyde
-
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyconiferaldehyde
S-adenosyl-L-homocysteine + sinapaldehyde
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferulic acid
?
-
OMT-15 shows 25% activity and OMT-17 shows 18% activity compared to myricetin
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferulic acid
?
high activity
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferuoyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferuoyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferuoyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferuoyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferuoyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferuoyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferuoyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxyferuoyl-CoA
S-adenosyl-L-homocysteine + sinapoyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + baicalein
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + baicalein
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + baicalein
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + baicalein
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ferulic acid
-
activity in presence of Co2+, no activity in presence of Mg2+
-
-
?
S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ferulic acid
10% of the activity with luteolin
synthesis of a single meta-methylated product
-
?
S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ferulic acid
-
-
-
?
S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ferulic acid
-
-
-
?
S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ferulic acid
-
-
-
?
S-adenosyl-L-methionine + caffeic acid ethyl ester
?
low activity
-
-
?
S-adenosyl-L-methionine + caffeic acid ethyl ester
?
moderate activity
-
-
?
S-adenosyl-L-methionine + caffeic alcohol
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeic alcohol
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeic alcohol
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeic alcohol
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + caffeoyl aldehyde
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl aldehyde
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl aldehyde
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl aldehyde
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
enzyme predicted to catalyze first methylation step during biosynthesis of monolignols
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
enzyme responsible for the first methylation step during biosynthesis of monolignols
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
possibly involved in biosynthesis of oat avenanthramide phytoalexins
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
preferred substrate, 3' methylating activity
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
bi-functional enzyme, involved in lignin biosynthesis
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
the enzyme is involved in lignin biosynthesis
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
trans-caffeoyl-CoA preferred
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
inducible
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
bi-functional enzyme, involved in lignin biosynthesis
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
reaction of the overall disease resistance response of plants
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
enzyme plays a pivotal role in cell wall reinforcement during the induced disease resistance response
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
if CCoAOMT and cinnamoyl co-enzyme A reductase are coupled together, they can convert caffeoyl-CoA to coniferaldehyde if pH changes from 7.5 to 6.0
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
best substrate
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
moderate activity
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
Zinnia sp.
-
-
-
-
?
S-adenosyl-L-methionine + caffeoyl-CoA
S-adenosyl-L-homocysteine + feruloyl-CoA
Zinnia sp.
-
essential role in the synthesis of guaiacyl lignin units as well as in the supply of substrates for the synthesis of syringyl lignin units
-
-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + esculetin
S-adenosyl-L-homocysteine + ?
20% of the activity with luteolin
-
-
?
S-adenosyl-L-methionine + esculetin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + esculetin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + esculetin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + esculetin
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + scoparol
-
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + scoparol
-
synthesis of a single meta-methylated product
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + scoparol
-
-
-
?
S-adenosyl-L-methionine + quercetin
?
moderate activity
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + isorhamnetin
60% of the activity with luteolin
synthesis of a single meta-methylated product
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + isorhamnetin
best substrate
-
-
?
S-adenosyl-L-methionine + scutellarein
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + scutellarein
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + scutellarein
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + scutellarein
S-adenosyl-L-homocysteine + ?
-
-
-
?
additional information
?
-
enzyme shows a strong preference for methylating the para position of flavanones and dihydroflavonols, whereas flavones and flavonols are methylated in the meta-position
-
-
?
additional information
?
-
-
enzyme shows a strong preference for methylating the para position of flavanones and dihydroflavonols, whereas flavones and flavonols are methylated in the meta-position
-
-
?
additional information
?
-
enzyme CCoAOMT7 binds to S-adenosyl-L-homocysteine hydrolase (SAHH) and S-adenosyl-L-methionine synthases (SAMSs) in vivo
-
-
-
additional information
?
-
CCoAOMT7 in Arabidopsis thaliana shows a strong preference to methylate para-position of flavanones and dihydroflavonols, and also a relatively lower activity on caffeoyl-CoA using S-adenosyl-L-methionine (SAM or AdoMet) as methyl donor to produce feruloyl-CoA. CCoAOMT7 also shows methyltransferase activity on caffeoyl CoA, although it shows the highest activity on luteolin, a kind of flavonoids
-
-
-
additional information
?
-
enzyme CCoAOMT7 binds to S-adenosyl-L-homocysteine hydrolase (SAHH) and S-adenosyl-L-methionine synthases (SAMSs) in vivo
-
-
-
additional information
?
-
CCoAOMT7 in Arabidopsis thaliana shows a strong preference to methylate para-position of flavanones and dihydroflavonols, and also a relatively lower activity on caffeoyl-CoA using S-adenosyl-L-methionine (SAM or AdoMet) as methyl donor to produce feruloyl-CoA. CCoAOMT7 also shows methyltransferase activity on caffeoyl CoA, although it shows the highest activity on luteolin, a kind of flavonoids
-
-
-
additional information
?
-
the enzyme is not able to methylate caffeic acid, 5-hydroxyferulic acid, 5-hydroxyconiferyl alcohol, kaempferol and naringenin
-
-
-
additional information
?
-
-
the enzyme is not able to methylate caffeic acid, 5-hydroxyferulic acid, 5-hydroxyconiferyl alcohol, kaempferol and naringenin
-
-
-
additional information
?
-
-
no activity with catechol, kaempferol, coniferyl aldehyde, and coniferyl alcohol
-
-
-
additional information
?
-
CoA and caffeoyl CoA are binding with high affinity to the enzymes in the presence and absence of S-adenosyl-L-methionine, thereby with higher affinity to isozyme CCoAOMT2 than CCoAOMT1, molecular dynamics, simulations, and docking analysis, overview. Conserved active site residues Met58, Thr60, Val63, Glu82, Gly84, Ser90, Asp160, Asp162, Thr169, Asn191 and Arg203 in CCoAOMT1 and CCoAOMT2 enzymes create the positive charge to balance the negatively charged caffeoyl CoA and play an important role in maintaining a functional conformation and are directly involved in donor substrate binding
-
-
?
additional information
?
-
CoA and caffeoyl CoA are binding with high affinity to the enzymes in the presence and absence of S-adenosyl-L-methionine, thereby with higher affinity to isozyme CCoAOMT2 than CCoAOMT1, molecular dynamics, simulations, and docking analysis, overview. Conserved active site residues Met58, Thr60, Val63, Glu82, Gly84, Ser90, Asp160, Asp162, Thr169, Asn191 and Arg203 in CCoAOMT1 and CCoAOMT2 enzymes create the positive charge to balance the negatively charged caffeoyl CoA and play an important role in maintaining a functional conformation and are directly involved in donor substrate binding
-
-
?
additional information
?
-
CCoAOMT down-regulation induces changes in xylem cell-wall structure and the lignin fractions
-
-
?
additional information
?
-
-
CCoAOMT down-regulation induces changes in xylem cell-wall structure and the lignin fractions
-
-
?
additional information
?
-
flax CCoAOMT possesses a small, but probably significant 5' methylating activity, in addition to a more usual 3' methylating activity
-
-
?
additional information
?
-
-
flax CCoAOMT possesses a small, but probably significant 5' methylating activity, in addition to a more usual 3' methylating activity
-
-
?
additional information
?
-
-
no activity with catechol, kaempferol, coniferyl aldehyde, and coniferyl alcohol
-
-
-
additional information
?
-
-
no activity with catechol, kaempferol, coniferyl aldehyde, and coniferyl alcohol
-
-
-
additional information
?
-
in silico studies suggest that alcoholic and aldehydic substrates are preferred to those of caffeic, sinapic, and ferulic acid by both caffeic acid-O-methyltransferase, EC 2.1.1.68, and caffeoyl-coenzyme A-O-methyltransferase with a marked preference for CoA ester substrates over free acids, aldehydes, and alcohols
-
-
?
additional information
?
-
-
in silico studies suggest that alcoholic and aldehydic substrates are preferred to those of caffeic, sinapic, and ferulic acid by both caffeic acid-O-methyltransferase, EC 2.1.1.68, and caffeoyl-coenzyme A-O-methyltransferase with a marked preference for CoA ester substrates over free acids, aldehydes, and alcohols
-
-
?
additional information
?
-
a catalytic triad, consisting of Lys157-Asn181-Asp228 residues is required for complete methyl transfer in case of a cation-dependent phenylpropanoid and flavonoid O-methyl transferase. This triad appears essential for efficient methyl transfer to catechol-like hydroxyl group in phenolics. The triad is conserved among all characterized plant caffeoyl coenzyme A O-methyltransferase-like enzymes
-
-
?
additional information
?
-
-
caffeoyl-CoA preferred to 5-hydroxyferuoyl-CoA
-
-
?
additional information
?
-
COMT catalyzes the multi-step methylation reactions of hydroxylated monomeric lignin precursors, and plays a pivotal position in the lignin biosynthetic pathway
-
-
?
additional information
?
-
-
COMT catalyzes the multi-step methylation reactions of hydroxylated monomeric lignin precursors, and plays a pivotal position in the lignin biosynthetic pathway
-
-
?
additional information
?
-
-
OMT-15 and -17 cannot utilize naringenin, apigenin, or kaempferol as substrates, taxifolin and eriodictyol do not serve as methyl acceptors
-
-
?
additional information
?
-
-
no substrates are caffeic acid, bergaptol, xanthotoxol, luteolin, esculetin
-
-
?
additional information
?
-
-
no activity with caffeic acid or 5-hydroxyferulic acid
-
-
-
additional information
?
-
no activity with catechol, kaempferol, caffeoyl aldehyde, caffeoyl acid, coniferyl aldehyde, and coniferyl alcohol
-
-
-
additional information
?
-
-
no activity with catechol, kaempferol, caffeoyl aldehyde, caffeoyl acid, coniferyl aldehyde, and coniferyl alcohol
-
-
-
additional information
?
-
no activity with kaempferol and dihydrokaempferol
-
-
-
additional information
?
-
-
no activity with kaempferol and dihydrokaempferol
-
-
-
additional information
?
-
CCoAOMT2 possesses more affinity toward caffeoyl CoA, feruloyl CoA, 5-hydroxy feruloyl CoA and sinapoyl CoA than CCoAOMT1
-
-
?
additional information
?
-
CCoAOMT2 possesses more affinity toward caffeoyl CoA, feruloyl CoA, 5-hydroxy feruloyl CoA and sinapoyl CoA than CCoAOMT1
-
-
?
additional information
?
-
no activity with caffeic acid, 5-hydroxyferuloyl-CoA, feruloyl-CoA, 4-coumaroyl-CoA, and 5-hydroxyferuloyl-CoA
-
-
-
additional information
?
-
-
no activity with caffeic acid, 5-hydroxyferuloyl-CoA, feruloyl-CoA, 4-coumaroyl-CoA, and 5-hydroxyferuloyl-CoA
-
-
-
additional information
?
-
COMT catalyzes the multi-step methylation reactions of hydroxylated monomeric lignin precursors, and plays a pivotal position in the lignin biosynthetic pathway
-
-
?
additional information
?
-
-
COMT catalyzes the multi-step methylation reactions of hydroxylated monomeric lignin precursors, and plays a pivotal position in the lignin biosynthetic pathway
-
-
?
additional information
?
-
the enzyme is capable of 3'- and 5'-methylating not only acid, aldehyde and alcohol precursors, but also ester precursors, broad substrate specificity, overview
-
-
?
additional information
?
-
-
the enzyme is capable of 3'- and 5'-methylating not only acid, aldehyde and alcohol precursors, but also ester precursors, broad substrate specificity, overview
-
-
?
additional information
?
-
-
very poor substrates: 4-coumarate, caffeate, ferulate, 5-hydroxyferulate and sinapate, coumarylaldehyde, caffeoyaldehyde, coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaryl alcohol, caffeoyl alcohol, coniferyl alcohol, 5-hydroxyconiferyl alcohol and sinapyl alcohol
-
-
?
additional information
?
-
-
recombinant TaCCoAOMT1 protein can only use caffeoyl-CoA and 5-hydroxyferuloyl-CoA as effective substrates and caffeoyl-CoA as the best substrate. No activity with p-coumarate, caffeate, ferulate, 5-hydroxyferulate, sinapate, coumarylaldehyde, caffeoyaldehyde, coniferaldehyde, 5-hydroxyconiferaldehyde, and sinapaldehyde, 4-coumaryl alcohol, caffeoyl alcohol, coniferyl alcohol, 5-hydroxyconiferyl alcohol, and sinapyl alcohol
-
-
-
additional information
?
-
enzyme prefers as a substrate the flavone tricetin. Enzyme shows a lower activity with vanillin precursor, 3,4-dihydroxybenzaldehyde, than with tricetin
-
-
?
additional information
?
-
enzyme prefers as a substrate the flavone tricetin. Enzyme shows a lower activity with vanillin precursor, 3,4-dihydroxybenzaldehyde, than with tricetin
-
-
?
additional information
?
-
-
enzyme prefers as a substrate the flavone tricetin. Enzyme shows a lower activity with vanillin precursor, 3,4-dihydroxybenzaldehyde, than with tricetin
-
-
?
additional information
?
-
-
caffeoyl-CoA preferred to 5-hydroxyferuoyl-CoA
-
-
?
