2.1.1.101: macrocin O-methyltransferase

This is an abbreviated version!
For detailed information about macrocin O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.101

2.1.1.101

tylosin

fradiae

macrolide

cosmid

pharmacology

conversions

agriculture

Reaction

Synonyms

macrocin methyltransferase, S-adenosyl-L-methionine-macrocin O-methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.101 macrocin O-methyltransferase

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Results	in table
76	AA Sequence
3	Application
1	CAS Registry Number
1	General Information
18	Inhibitors
11	Ki Value [mM]
6	KM Value [mM]
12	Metals/Ions
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
5	Organism
4	Pathway
4	pH Optimum
2	Purification (Commentary)
2	Reaction
1	Reaction Type
5	Reference
1	Specific Activity [micromol/min/mg]
4	Storage Stability
16	Substrates and Products (Substrate)
2	Subunits
2	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

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Reference on EC 2.1.1.101 - macrocin O-methyltransferase

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485047

Seno, E.T.; Baltz, R.H.

Properties of S-adenosyl-L-methionine:macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylations

Antimicrob. Agents Chemother.

370-377

1981

Streptomyces fradiae

7305323

485048

Bauer, N.J.; Kreuzman, A.J.; Dotzlaf, J.E.; Yeh, W.K.

Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae

J. Biol. Chem.

263

15619-15625

1988

Streptomyces fradiae

3170601

485049

Yeh, W.K.; Bauer, N.J.; Dotzlaf, J.E.

High-performance liquid chromatographic assay for S-adenosyl-L-methionine: macrocin O-methyltransferase

J. Chromatogr.

288

157-165

1984

Streptomyces fradiae

6725471

485050

Kreuzman, A.J.; Turner, J.R.; Yeh, W.K.

Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism

J. Biol. Chem.

263

15626-15633

1988

Streptomyces fradiae

3170602

757458

Kim, E.; Song, M.; Kim, M.; Beom, J.; Lee, E.; Kim, D.; Nam, S.; Yoon, Y.

Characterization of the two methylation steps involved in the biosynthesis of mycinose in tylosin

J. Nat. Prod.

2014-2021

2016

Streptomyces fradiae (Q9S4D5)

2743999