1.8.99.5: dissimilatory sulfite reductase
This is an abbreviated version!
For detailed information about dissimilatory sulfite reductase, go to the full flat file.
Word Map on EC 1.8.99.5
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1.8.99.5
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sulfate-reducing
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desulfovibrio
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thiosulfate
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sulfur-oxidizing
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biogeochemical
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desulfobacteraceae
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geochemical
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vinosum
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desulfotomaculum
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allochromatium
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phylotypes
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adenosine-5'-phosphosulfate
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desulfoviridin
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desulfobulbus
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desulfosarcina
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hildenborough
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desulfobulbaceae
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chemotrophic
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desulfovibrionaceae
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low-sulfate
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sulfidogenic
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aarhus
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deltaproteobacterial
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chlorobaculum
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methane-oxidizing
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hydrogenotrophic
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desulfobacterium
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desulfomicrobium
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sirohaem
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desulfococcus
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t-rflp
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desulfosporosinus
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anme-2
- 1.8.99.5
-
sulfate-reducing
- desulfovibrio
- thiosulfate
-
sulfur-oxidizing
-
biogeochemical
- desulfobacteraceae
-
geochemical
- vinosum
- desulfotomaculum
- allochromatium
-
phylotypes
- adenosine-5'-phosphosulfate
-
desulfoviridin
- desulfobulbus
- desulfosarcina
- hildenborough
- desulfobulbaceae
-
chemotrophic
- desulfovibrionaceae
-
low-sulfate
-
sulfidogenic
-
aarhus
-
deltaproteobacterial
- chlorobaculum
-
methane-oxidizing
-
hydrogenotrophic
- desulfobacterium
- desulfomicrobium
-
sirohaem
- desulfococcus
-
t-rflp
- desulfosporosinus
-
anme-2
Reaction
Synonyms
CNL05500, dSiR, DsrA, DsrAB, DsrC, DsvA, DsvB, hydrogen-sulfide:(acceptor) oxidoreductase, MET5, octahaemcytochrome c MccA, PAE2566, SiRA, siroheme sulfite reductase, sulfite reductase
ECTree
1.8.99.5 dissimilatory sulfite reductaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.8.99.5 - dissimilatory sulfite reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
hydroxylamine + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+
? + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O
nitrite + a [DsrC protein]-dithiol + 2 reduced acceptor
? + a [DsrC protein]-disulfide + 2 acceptor + 2 H2O
SeO32- + a [DsrC protein]-dithiol + 2 reduced methyl viologen + 2 H+
HSe- + a [DsrC protein]-disulfide + 2 oxidized methyl viologen + 3 H2O
-
-
40% of the activity with sulfite
-
?
sulfite + 6 ferrocytochrome c + 6 H+
sulfide + 6 ferricytochrome c + 3 H2O
overall transfer of 6 electrons during the reaction
-
-
?
sulfite + a [DsrC protein]-dithiol + 2 reduced ferredoxin + 2 H+
hydrogen sulfide + a [DsrC protein]-disulfide + 2 oxidized ferredoxin + 3 H2O
sulfite + a [DsrC protein]-dithiol + reduced methyl viologen
trithionate + a [DsrC protein]-disulfide + oxidized methyl viologen
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O
sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
-
-
-
-
?
hydroxylamine + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+
? + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O
-
-
50% of the activity with sulfite
-
?
hydroxylamine + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+
? + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O
-
-
-
-
?
hydroxylamine + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+
? + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O
-
-
-
-
?
nitrite + a [DsrC protein]-dithiol + 2 reduced acceptor
? + a [DsrC protein]-disulfide + 2 acceptor + 2 H2O
-
-
25% of the activity with sulfite
-
?
nitrite + a [DsrC protein]-dithiol + 2 reduced acceptor
? + a [DsrC protein]-disulfide + 2 acceptor + 2 H2O
-
-
-
-
?
nitrite + a [DsrC protein]-dithiol + 2 reduced acceptor
? + a [DsrC protein]-disulfide + 2 acceptor + 2 H2O
-
-
-
-
?
sulfite + a [DsrC protein]-dithiol + 2 reduced ferredoxin + 2 H+
hydrogen sulfide + a [DsrC protein]-disulfide + 2 oxidized ferredoxin + 3 H2O
-
-
overall reaction
-
?
sulfite + a [DsrC protein]-dithiol + 2 reduced ferredoxin + 2 H+
hydrogen sulfide + a [DsrC protein]-disulfide + 2 oxidized ferredoxin + 3 H2O
-
-
overall reaction
-
?
sulfite + a [DsrC protein]-dithiol + 2 reduced ferredoxin + 2 H+
hydrogen sulfide + a [DsrC protein]-disulfide + 2 oxidized ferredoxin + 3 H2O
-
-
overall reaction
-
?
sulfite + a [DsrC protein]-dithiol + reduced methyl viologen
trithionate + a [DsrC protein]-disulfide + oxidized methyl viologen
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-
trithionate is the major product, plus formation of thiosulfate and sulfid
-
?
sulfite + a [DsrC protein]-dithiol + reduced methyl viologen
trithionate + a [DsrC protein]-disulfide + oxidized methyl viologen
-
-
trithionate is the major product, plus formation of thiosulfate and sulfid
-
?
sulfite + a [DsrC protein]-dithiol + reduced methyl viologen
trithionate + a [DsrC protein]-disulfide + oxidized methyl viologen
-
-
trithionate is the major product with reduced methyl viologen as electron donor
-
?
additional information
?
-
-
no substrates: S3O62-, S2O32-. Methyl viologen is as effective as ferredoxin in coupling the sulfite reductase with hydrogenase while benzyl viologen is only 16% as effective as ferredoxin. No activity is observed with NAD, NADP, FAD or FMN. Varying the substrate concentration [SO 2-] from 1 to 2.5 micromol affects the stoichiometry of the enzyme reaction by alteration of the ratio of H2 uptake to S2- formed from 2.5:1 to 3.1:1
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-
?
additional information
?
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the enzyme catalyzes the reduction of sulfite to sulfide
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-
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additional information
?
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the enzyme catalyzes the reduction of sulfite to sulfide
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-
-
additional information
?
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the enzyme catalyzes the reduction of sulfite to sulfide
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-
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additional information
?
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two-state hypothesis for enzyme activity: an active form (DVa) binds and catalyzes substrate reduction, and an inactive form (DVi) exists for the resting enzyme. Only the active form of the enzyme need be considered during steady-state turnover. Determination of the rate constants defining these structural perturbations, from oxidized to reduced and reduced to oxidized states
-
-
?
additional information
?
-
-
two-state hypothesis for enzyme activity: an active form (DVa) binds and catalyzes substrate reduction, and an inactive form (DVi) exists for the resting enzyme. Only the active form of the enzyme need be considered during steady-state turnover. Determination of the rate constants defining these structural perturbations, from oxidized to reduced and reduced to oxidized states
-
-
?
additional information
?
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multiheme cytochrome c enzymes catalyse complex-multi-electron redox reactions and bind their substrates through the free electron pairs of a heteroatom to a free coordination position at an active-site hem group. Electrons are then provided or accepted by the tightly coupled chain of heme groups
-
-
?
additional information
?
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MccA reduces sulfite, but not arsenate, selenate, selenite, hydroxylamine, hydrazine, fumarate, nitrate, thiosulfate, tetrathionate, polysulfide, or Fe(III). Nitrite is reduced only very slowly to ammonium
-
-
?
