1.8.99.5: dissimilatory sulfite reductase
This is an abbreviated version!
For detailed information about dissimilatory sulfite reductase, go to the full flat file.
Word Map on EC 1.8.99.5
-
1.8.99.5
-
sulfate-reducing
-
desulfovibrio
-
thiosulfate
-
sulfur-oxidizing
-
biogeochemical
-
desulfobacteraceae
-
geochemical
-
vinosum
-
desulfotomaculum
-
allochromatium
-
phylotypes
-
adenosine-5'-phosphosulfate
-
desulfoviridin
-
desulfobulbus
-
desulfosarcina
-
hildenborough
-
desulfobulbaceae
-
chemotrophic
-
desulfovibrionaceae
-
low-sulfate
-
sulfidogenic
-
aarhus
-
deltaproteobacterial
-
chlorobaculum
-
methane-oxidizing
-
hydrogenotrophic
-
desulfobacterium
-
desulfomicrobium
-
sirohaem
-
desulfococcus
-
t-rflp
-
desulfosporosinus
-
anme-2
- 1.8.99.5
-
sulfate-reducing
- desulfovibrio
- thiosulfate
-
sulfur-oxidizing
-
biogeochemical
- desulfobacteraceae
-
geochemical
- vinosum
- desulfotomaculum
- allochromatium
-
phylotypes
- adenosine-5'-phosphosulfate
-
desulfoviridin
- desulfobulbus
- desulfosarcina
- hildenborough
- desulfobulbaceae
-
chemotrophic
- desulfovibrionaceae
-
low-sulfate
-
sulfidogenic
-
aarhus
-
deltaproteobacterial
- chlorobaculum
-
methane-oxidizing
-
hydrogenotrophic
- desulfobacterium
- desulfomicrobium
-
sirohaem
- desulfococcus
-
t-rflp
- desulfosporosinus
-
anme-2
Reaction
+ 2 acceptor + 3 H2O = + + 2 reduced acceptor + 2 H+
Synonyms
CNL05500, dSiR, DsrA, DsrAB, DsrC, DsvA, DsvB, hydrogen-sulfide:(acceptor) oxidoreductase, MET5, octahaemcytochrome c MccA, PAE2566, SiRA, siroheme sulfite reductase, sulfite reductase
ECTree
Advanced search results
Cofactor
Cofactor on EC 1.8.99.5 - dissimilatory sulfite reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
heme
octaheme cytochrome, a homotrimer with an unprecedented fold and heme arrangement, as well as a heme bound to a CX15CH motif. The heterobimetallic active-site heme 2 has a Cu(I) ion juxtaposed to a heme c at a Fe-Cu distance of 4.4 A, active-site heme 2 is bound to a canonical CXXCH motif with H306 as a proximal axial ligand. In the CX15CH motif of heme 8, the extended region between the two cysteine residues forms a loop with a short helical turn, in direct vicinity to another loop harbouring the only non-proline cis peptide in the enzyme, between residues G508 and F509. Its formation might require the essential peptidyl isomerase MccB2, and it is presumed to be a prerequisite for correct folding of the loop in the maturation process of heme 8, which is likely to be attached by the dedicated cytochrome c synthase CcsA1. The structure of the CX15CH heme c binding motif disrupts the general parallel/perpendicular heme stacking sequence, and rotates the heme out of plane, possibly to optimize the interaction with the putative electron donor, the iron-sulfur protein MccC
additional information
-
no activity is observed with NAD, NADP, FAD or FMN
-
-
at least two of three subunits contain two pairs of [Fe4-S4]-centers and siroheme units
siroheme
O93650; O93651
binding of two sirohemes and four [4Fe-4S]-clusters per alpha2beta2 structure
siroheme
Q9ZH18; Q9ZH17
binding of two sirohemes and four [4Fe-4S]-clusters per alpha2beta2 structure
siroheme
-
close to 80% of the siroheme moiety in the enzyme is demetallated
siroheme
protein complex contains two siroheme-[4Fe4S] cofactors bound by subunit DsrB, two sirohydrochlorins and two [4Fe-4S]-centers bound by subunit DsrA, and another four [4Fe-4S]-centers in the ferredoxin domains
-
at least two of three subunits contain two pairs of [Fe4-S4]-centers and siroheme units
[4Fe-4S]-center
O93650; O93651
binding of two sirohemes and four [4Fe-4S]-clusters per alpha2beta2 structure
[4Fe-4S]-center
Q9ZH18; Q9ZH17
binding of two sirohemes and four [4Fe-4S]-clusters per alpha2beta2 structure
[4Fe-4S]-center
protein complex contains two siroheme-[4Fe4S] cofactors bound by subunit DsrB, two sirohydrochlorins and two [4Fe-4S]-centers bound by subunit DsrA, and another four [4Fe-4S]-centers in the ferredoxin domains