1.8.4.13: L-methionine (S)-S-oxide reductase
This is an abbreviated version!
For detailed information about L-methionine (S)-S-oxide reductase, go to the full flat file.
Reaction
Synonyms
EC 1.8.4.5, free-methionine-R-sulfoxide reductase, fRMsr, fSMsr, methionine sulfoxide reductase
ECTree
1.8.4.13 L-methionine (S)-S-oxide reductaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.8.4.13 - L-methionine (S)-S-oxide reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-methionine (S)-S-oxide + reduced DTT
L-methionine + oxidized DTT + H2O
-
highest activity at 10 mM
-
-
?
L-methionine (S)-sulfoxide + NADPH + H+
L-methionine + NADP+ + H2O
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
L-methionine sulfoxide enkephalin + NADPH
L-methionine enkephalin + NADP+ + H2O
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
L-methionine-(S)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
-
-
-
?
N-acetyl-L-methionine (S)-sulfoxide + thioredoxin
N-acetyl-L-methionine + thioredoxin disulfide + H2O
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
L-(-)-methionine S-oxide + NADPH
L-methionine + NADP+ + H2O
-
the enzyme is specific for the L-(-)-stereoisomer
-
-
ir
L-(-)-methionine S-oxide + NADPH
L-methionine + NADP+ + H2O
-
the enzyme is absolutely specific for the L-(-)-stereoisomer
-
-
ir
L-methionine (S)-S-oxide + NADPH
L-methionine + NADP+ + H2O
-
substrate is L-Met-DL-sulfoxide or L-Met-L-sulfoxide
-
-
?
L-methionine (S)-S-oxide + NADPH
L-methionine + NADP+ + H2O
-
substrate is L-Met-DL-sulfoxide or L-Met-L-sulfoxide
-
-
?
sulindac + NADPH
sulindac sulfide + NADP+ + H2O
-
activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr
activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity
-
?
sulindac + NADPH
sulindac sulfide + NADP+ + H2O
-
activity with membrane-bound enzyme form Mem-R,S-Msr
-
-
?
additional information
?
-
-
the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions
-
-
?
additional information
?
-
-
substrate specificity, overview, Mem-R,S-Msr can also catalyze the reduction of L-methionine (R)-sulfoxide, EC 1.8.4.14, enzyme reduces oxidized methionine residues of the ribosomal protein L12, which becomes reversibly inactivated and forms monomers instead of dimers upon oxidation
-
-
?
additional information
?
-
-
no activity with peptide-L-methionine-(S)-S-oxide
-
-
?
additional information
?
-
-
methionine sulfoxide reduction pathway, overview
-
-
?
additional information
?
-
-
the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues
-
-
?
additional information
?
-
-
the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues
-
-
?
additional information
?
-
-
the purified enzyme may contain thioredoxin
-
-
?
