1.8.1.B1: thioredoxin glutathione reductase

This is an abbreviated version!
For detailed information about thioredoxin glutathione reductase, go to the full flat file.

Word Map on EC 1.8.1.B1

1.8.1.B1

schistosoma

schistosomiasis

worm

mansoni

praziquantel

glutaredoxin

selenocysteine

antischistosomal

gssg

auranofin

platyhelminth

flatworm

dtnb

fluke

sjtgr

fasciola

oxadiazole

cysticerci

hysteretic

medicine

taenia

trematode

echinococcus

granulosus

schistosomicidal

crassiceps

gigantica

selenocysteine-containing

furoxans

analysis

Reaction

= 2 glutathione +

Synonyms

cTGR, DmTrxR, EgTGR, mTGR, SmTGR, TGR, TGRsec, thioredoxin glutathione reductase, thioredoxin-glutathione reductase, thioredoxin/glutathione reductase

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.1.B1 thioredoxin glutathione reductase

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Results	in table
11	AA Sequence
11	Application
18	Cloned(Commentary)
28	Cofactor
8	Crystallization (Commentary)
27	Disease/ Diagnostics
1	Expression
16	General Information
4	General Stability
84	IC50 Value
89	Inhibitors
30	kcat/KM [mM/s]
4	Ki Value [mM]
81	KM Value [mM]
9	Localization
10	Metals/Ions
12	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
65	Organism
5	pH Optimum
4	pI Value
1	Posttranslational Modification
21	Protein Variants
19	Purification (Commentary)
1	Reaction
63	Reference
19	Source Tissue
21	Specific Activity [micromol/min/mg]
1	Storage Stability
101	Substrates and Products (Substrate)
13	Subunits
86	Synonyms
3	Temperature Optimum [°C]
1	Temperature Range [°C]
71	Turnover Number [1/s]

Disease

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Disease on EC 1.8.1.B1 - thioredoxin glutathione reductase

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Infections

Unusual thiol-based redox metabolism of parasitic flukes.

27238582

[Study on immunologic function of thioredoxin glutathione reductase from Schistosoma japonicum].

26767257

Malaria

Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition.

22177949

Schistosomiasis

Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis.

31939288

Computer-Aided Drug Design for the Identification of Novel Antischistosomal Compounds.

32451992

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.

29800515

High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis.

26341081

Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.

21630672

Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography.

20659890

Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments.

33950676

Proteomic profiling of nitrosative stress: protein s-oxidation accompanies s-nitrosylation.

24397869