1.8.1.B1: thioredoxin glutathione reductase
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For detailed information about thioredoxin glutathione reductase, go to the full flat file.
Word Map on EC 1.8.1.B1
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1.8.1.B1
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schistosoma
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schistosomiasis
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worm
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mansoni
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praziquantel
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glutaredoxin
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selenocysteine
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antischistosomal
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gssg
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auranofin
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platyhelminth
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flatworm
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dtnb
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fluke
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sjtgr
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fasciola
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oxadiazole
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cysticerci
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hysteretic
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medicine
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taenia
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trematode
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echinococcus
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granulosus
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schistosomicidal
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crassiceps
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gigantica
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selenocysteine-containing
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furoxans
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analysis
- 1.8.1.B1
- schistosoma
- schistosomiasis
- worm
- mansoni
- praziquantel
- glutaredoxin
- selenocysteine
-
antischistosomal
- gssg
- auranofin
-
platyhelminth
- flatworm
- dtnb
- fluke
-
sjtgr
- fasciola
-
oxadiazole
- cysticerci
-
hysteretic
- medicine
-
taenia
-
trematode
-
echinococcus
- granulosus
-
schistosomicidal
- crassiceps
- gigantica
-
selenocysteine-containing
- furoxans
- analysis
Reaction
Synonyms
cTGR, DmTrxR, EgTGR, mTGR, SmTGR, TGR, TGRsec, thioredoxin glutathione reductase, thioredoxin-glutathione reductase, thioredoxin/glutathione reductase
ECTree
1.8.1.B1 thioredoxin glutathione reductaseAdvanced search results
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Application on EC 1.8.1.B1 - thioredoxin glutathione reductase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
analysis
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development of a cost sensitive classification model to evaluate the biological activity of inhibitors. Random forest analysis revealed 10 highly enriched scaffolds in the actives dataset. Models are evaluated using docking approaches
drug development
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identification of inhibitory compounds facilitates further development of anti-schistosomiasis drugs with novel mechanism of action
medicine
medicine
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identification of oxadiazole 2-oxides (TGR inhibitors) as new lead compounds for schistosomiasis chemotherapy
medicine
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quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade, several of which are highly potent and should serve both as mechanistic tools for probing the redox balance in Schistosome mansoni, and starting points for developing medicinal leads for treatments for schistosomiasis
medicine
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the enzyme presents a target for anti-schistosomiasis drug development
medicine
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the enzyme is a potential target for development of novel agents against schistosomes
medicine
the enzyme is a promising target for anti Fasciola treatments
medicine
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enzyme can be used as a diagnostic target antigen for Schistosama mansoni infection in serum and urine. Sandwich ELISA detects the protein with high diagnostic efficiency in individuals with high or low worm burden
