1.8.1.18: NAD(P)H sulfur oxidoreductase (CoA-dependent)
This is an abbreviated version!
For detailed information about NAD(P)H sulfur oxidoreductase (CoA-dependent), go to the full flat file.
Reaction
Synonyms
CoA-dependent NAD(P)H: elemental sulfur (S0) oxidoreductase, coenzyme A-dependent NADPH sulfur oxidoreductase, NAD(P)H-dependent sulfur reductase, NAD(P)H: S0 oxidoreductase, NADPH NSR, NSR, PF1186, S(0) reductase, TK1186, TK1299
ECTree
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Cofactor
Cofactor on EC 1.8.1.18 - NAD(P)H sulfur oxidoreductase (CoA-dependent)
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NADH
activity with NADH is 50% compared to the activity with NADPH
CoA
activities in the presence of NADPH or NADH are completely lost in the absence of CoASH, demonstrating strict CoA-dependency of the enzyme for sulfur reduction. KM: 0.26 mM
PF1186 is a member of a large family of flavin adenine dinucleotide (FAD)-dependent pyridine nucleotide-disulfide oxidoreductase genes
FAD
addition of FAD increases the activity, potentially reflecting the promoted formation of the active holoenzyme
FAD
B2BSJ7; B2BSJ6; B2BSJ5; B2BSK0
the purified recombinant NsoC contains one FAD cofactor per protein molecule
NADPH
activity with NADH is 50% compared to the activity with NADPH
NADPH
the enzyme exhibits activity with preference to NADPH as an electron donor, as indicated by higher specific activity with NADPH (14.0 U/mg) than with NADH (0.75 U/mg) NADH