1.7.1.7: GMP reductase
This is an abbreviated version!
For detailed information about GMP reductase, go to the full flat file.
Word Map on EC 1.7.1.7
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1.7.1.7
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purine
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imp
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salvage
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hypoxanthine
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impdhs
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hypoxanthine-guanine
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adenylosuccinate
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medicine
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drug development
- 1.7.1.7
- purine
- imp
-
salvage
- hypoxanthine
- impdhs
-
hypoxanthine-guanine
- adenylosuccinate
- medicine
- drug development
Reaction
Synonyms
EC 1.6.6.8, GMPR, GMPR-I, GMPR-II, GMPR2, guaC, Guanosine 5'-monophosphate oxidoreductase, guanosine 5'-monophosphate reductase, guanosine monophosphate reductase, guanosine monophosphate reductase 2, guanosine-5'-monophosphate reductase, guanylate reductase, HsGMPR1, HsGMPR2, LmGMPR, Lmj17.0725, LMJF_17_0725, NADPH:GMP oxidoreductase (deaminating), reductase, guanylate, Tb927.5.2080, TbGMPR, TcGMPR, TCIL3000_5_1940
ECTree
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Reaction
Reaction on EC 1.7.1.7 - GMP reductase
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IMP + NH3 + NADP+ = GMP + NADPH + H+
mechanism: ordered sequential with GMP binding first
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IMP + NH3 + NADP+ = GMP + NADPH + H+
ordered bi-bi kinetic mechanism, in which GMP binds first to the enzyme followed by NADPH binding, and NADP+ dissociates first followed by IMP release. GMP and IMP binding are thermodynamically favorable processes. Hydride transfer contributes to the rate-limiting step, and protonation and hydride transfer steps take place in the same transition state, lending support to a concerted mechanism. Product release does not contribute to the rate-limiting step of the reaction
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IMP + NH3 + NADP+ = GMP + NADPH + H+
ordered bibi kinetic mechanism, in which GMP binds first to the enzyme followed by NADPH binding, and NADP+ dissociates first followed by IMP release
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IMP + NH3 + NADP+ = GMP + NADPH + H+
catalytic reaction mechanism, overview. GMPR catalyzes two different chemical transformations at the same active site via two different cofactor conformations, analysis by subtesla high resolution field cycling NMR relaxometry