1.7.1.16: nitrobenzene nitroreductase
This is an abbreviated version!
For detailed information about nitrobenzene nitroreductase, go to the full flat file.
Word Map on EC 1.7.1.16
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1.7.1.16
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pseudoalcaligenes
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flavin
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hydroxylaminobenzene
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microbiol
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nitrofurazone
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fmn
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putida
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silica
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mutase
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two-electron
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analysis
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mononucleotide
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degradation
- 1.7.1.16
- pseudoalcaligenes
- flavin
- hydroxylaminobenzene
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microbiol
- nitrofurazone
- fmn
- putida
- silica
- mutase
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two-electron
- analysis
- mononucleotide
- degradation
Reaction
+ 2 NADP+ + = + 2 NADPH + 2 H+
Synonyms
cnbA, NbzA, NfsB, NTR, Oxygen-insensitive NAD(P)H nitroreductase
ECTree
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Application
Application on EC 1.7.1.16 - nitrobenzene nitroreductase
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analysis
degradation
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fluorescence imaging of nitroreductase in zebrafish in vivo using a newnear-infrared fluorescence off-on probe. The probe is prepared by connecting 4-nitrobenzene as a quenching and recognizing moiety to a stable hemicyanine skeleton. The fluorescence off-on response of the probe is based on the enzyme-catalyzed reduction of the 4-nitrobenzene moiety, followed by the 1,6-rearrangement-elimination and the fluorophore release. The probe exhibits good analytical performance such as near-infrared fluorescence emission over 700 nm as well as high selectivity and sensitivity, with a detection limit of 14 ng/ml. The probe has been applied to visualize the distribution of nitroreductase in living zebrafish in vivo
analysis
immobilization of enzyme on polyethyleneimine-mediated silica formation, enzyme activity is significantly more stable than NbzA in solution. A microfluidic microreactor is suitable for continuous operation using nitrobenzene, CB1954, and the proantibiotic nitrofurazone. The flow-through system provides a rapid and reproducible screening method for determining the NbzA-catalyzed activation of prodrugs and proantibiotics
analysis
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immobilization of enzyme on polyethyleneimine-mediated silica formation, enzyme activity is significantly more stable than NbzA in solution. A microfluidic microreactor is suitable for continuous operation using nitrobenzene, CB1954, and the proantibiotic nitrofurazone. The flow-through system provides a rapid and reproducible screening method for determining the NbzA-catalyzed activation of prodrugs and proantibiotics
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the strain can use nitrobenzene as the sole carbon and nitrogen source for growth, and completely degrade 300 mg nitrobenzene per litre within 14 h, at 20-35°C and pH 7.0-9.0. Strain 1 can also degrade aniline and phenol
degradation
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the strain can use nitrobenzene as the sole carbon and nitrogen source for growth, and completely degrade 300 mg nitrobenzene per litre within 14 h, at 20-35°C and pH 7.0-9.0. Strain 1 can also degrade aniline and phenol
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