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1.7.1.15: nitrite reductase (NADH)

This is an abbreviated version!
For detailed information about nitrite reductase (NADH), go to the full flat file.

Word Map on EC 1.7.1.15

Reaction

NH3
+ 3 NAD+ + 2 H2O =
nitrite
+ 3 NADH + 5 H+

Synonyms

assimilatory NADH-nitrite reductase, assimilatory nitrite reductase, BMWSH_4089, EC 1.6.6.4, NADH-dependent nitrite oxidoreductase, NADH-dependent nitrite reductase, NADH-nitrite oxidoreductase, NADH-nitrite reductase, NADH:nitrite oxidoreductase, NasB, NasB protein, nasD, NasDE, nasE, NIA1, Nia2, NiR, nirB, NirBD, nirD, nitrite reductase (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                1.7.1.15 nitrite reductase (NADH)

Inhibitors

Inhibitors on EC 1.7.1.15 - nitrite reductase (NADH)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,2'-dipyridyl
68% inhibition at 2 mM
azide
36% inhibition at 2 mM
Cyanate
27% inhibition at 2 mM
cyanide
dithioerythritol
52% inhibition at 2 mM
KCN
-
although 1 mM KCN completely inhibits hydroxylamine reduction, it does not inhibit the reduction of K3Fe(CN)6 and only decreases the rate of cytochrome c reduction by 12%
Mg2+
A0A8D4BLJ9; A0A8D4BRF4
1 mM, 82% of initial activity
NAD+
-
NAD+ shows mixed product inhibition with respect to NADH and mixed or uncompetitive inhibition with respect to hydroxylamine
nitrite
-
nitrite decrease the rate of NADH-dependent reduction of cytochrome c by 77% and that of Fe(CN)63- by 90%
o-phenanthroline
72% inhibition at 2 mM
p-chloromercuribenzoate
-
the reduction of cytochrome c, K3Fe(CN)6 and hydroxylamine is completely inhibited (more than 99%) by 0.02 mM p-chloromercuribenzoate
p-hydroxymercurybenzoate
48% inhibition at 2 mM
additional information
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