1.7.1.13: preQ1 synthase

This is an abbreviated version!
For detailed information about preQ1 synthase, go to the full flat file.

Word Map on EC 1.7.1.13

1.7.1.13

nucleoside

queuosine

7-aminomethyl-7-deazaguanine

adduct

gtp

reductases

imine

Reaction

+ 2 NADP⁺ =

+ 2 NADPH + 2 H+

Synonyms

7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase, 7-cyano-7-deazaguanine reductase, NADPH-dependent 7-cyano-7-deazaguanine reductase, nitrile reductase, NRed, preQ0 reductase, preQ0oxidoreductase, QueF, queuine synthase, YkvM

ECTree

1 Oxidoreductases

1.7 Acting on other nitrogenous compounds as donors

1.7.1 With NAD⁺ or NADP⁺ as acceptor

1.7.1.13 preQ1 synthase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
21201	AA Sequence
7	Cloned(Commentary)
8	Cofactor
5	Crystallization (Commentary)
3	Inhibitors
11	KM Value [mM]
4	Metals/Ions
3	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
20	Organism
3	Pathway
39	PDB ID
2	pH Optimum
1	pH Range
2	pH Stability
23	Protein Variants
4	Purification (Commentary)
1	Reaction
20	Reference
10	Specific Activity [micromol/min/mg]
1	Storage Stability
27	Substrates and Products (Substrate)
7	Subunits
29	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
10	Turnover Number [1/s]

Reaction

print visible entries

print all entries

Reaction on EC 1.7.1.13 - preQ1 synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Reaction Search

7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+

This enzyme catalyses one of the early steps in the synthesis of queosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, queuine tRNA-ribosyltransferase. Queosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies.