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1.6.5.5: NADPH:quinone reductase

This is an abbreviated version!
For detailed information about NADPH:quinone reductase, go to the full flat file.

Word Map on EC 1.6.5.5

Reaction

NADPH
+
H+
 + 2 quinone =
NADP+
 + 2 semiquinone

Synonyms

ArsH, Dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate) (quinone), DT-diaphorase, EC 1.6.99.2, Flavoprotein NAD(P)H:quinone reductase, Menadione oxidoreductase, Menadione reductase, NAD(P)H dehydrogenase, NAD(P)H dehydrogenase (quinone), NAD(P)H menadione reductase, NAD(P)H quinone reductase, NAD(P)H-quinone dehydrogenase, NAD(P)H-quinone oxidoreductase, NAD(P)H-quinone reductase, NAD(P)H:(quinone-acceptor) oxidoreductase, NAD(P)H:menadione oxidoreductase, NAD(P)H:paraquat diaphorase, NAD(P)H:quinone reductase, NADH-menadione reductase, NADH-menaquinone reductase, NADH:quinone reductase, NADPH DT-diaphorase, NADPH quinone acceptor oxidoreductase, NADPH-dependent quinone reductase, NADPH:azodicarbonyl/quinone reductase, NADPH:quinone oxidoreductase, NADPH:quinone reductase, Naphthoquinone reductase, NfsA, nitroreductase A, old yellow enzyme, ORF 17150, p-Benzoquinone reductase, P1-ZCr, P1-zeta-crystallin, P36, PA0660, Phylloquinone reductase, PtoQOR, QAO, Qor, QorA, Quinone reductase, Reduced NAD(P)H dehydrogenase, TcOYE, TmQR1, VAT-1, vesicle amine transport protein-1, Viologen accepting pyridine nucleotide oxidoreductase, Vitamin K reductase, ZCr, zeta-Crystallin, zeta-crystallin homolog protein, zeta-crystallin/NADPH:quinone oxidoreductase, zeta-Crystallin/quinone reductase, Zta1, Zta1p

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.5 With a quinone or similar compound as acceptor
                1.6.5.5 NADPH:quinone reductase

Disease

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Disease on EC 1.6.5.5 - NADPH:quinone reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Role of deadenylation and AUF1 binding in the pH-responsive stabilization of glutaminase mRNA.
Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability.
Zeta-crystallin: a tale of two cells.
Breast Neoplasms
Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene.
Carcinogenesis
DT-diaphorase: possible roles in cancer chemotherapy and carcinogenesis.
Long term effects of benzo(a)pyrene on the activity of NAD(P)H:quinone reductase in the forestomach and glandular stomach of ICR/Ha mice.
Carcinoma
Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.
Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin.
The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)
The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells.
Carcinoma, Ehrlich Tumor
Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene.
Carcinoma, Hepatocellular
1,2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells.
Direct determination of functional activity of cytochrome P-4501A1 and NADPH DT-diaphorase in hepatoma cell lines using noninvasive scanning laser cytometry.
Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens.
Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.
Mechanisms of induction of enzymes that protect against chemical carcinogenesis.
Mercurials and dimercaptans: synergism in the induction of chemoprotective enzymes.
Rapid detection of inducers of enzymes that protect against carcinogens.
The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells.
Cataract
A guinea-pig hereditary cataract contains a splice-site deletion in a crystallin gene.
Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms.
Association of hereditary cataracts in strain 13/N guinea-pigs with mutation of the gene for zeta-crystallin.
Expression of recombinant zeta-crystallin in Escherichia coli with the help of GroEL/ES and its purification.
Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase.
Mutant zeta-crystallin from guinea-pig hereditary cataracts has altered structural and enzymatic properties.
On the nature of hereditary cataract in strain 13/N guinea pigs.
The transcripts of zeta-crystallin, a lens protein related to the alcohol dehydrogenase family, are altered in a guinea-pig hereditary cataract.
Zeta-crystallin catalyzes the reductive activation of 2,4,6-trinitrotoluene to generate reactive oxygen species: a proposed mechanism for the induction of cataracts.
Colonic Neoplasms
NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.
Glioblastoma
Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration.
Glioma
Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration.
Infections
Differential regulation of wheat quinone reductases in response to powdery mildew infection.
Lens Diseases
A guinea-pig hereditary cataract contains a splice-site deletion in a crystallin gene.
Leukemia
{zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia.
Neoplasms
Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents.
Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma.
Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.
Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP.
Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor.
DT-diaphorase in morbidly obese patients.
DT-diaphorase: possible roles in cancer chemotherapy and carcinogenesis.
Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.
Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation.
Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues.
Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis.
Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene.
Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT-1 Controlled Pathways.
Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer.
Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.
Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice.
Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs.
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.
Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors.
Zeta-crystallin: a moonlighting player in cancer.
Pancreatic Neoplasms
Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism.
Papilloma
Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor.
Paralysis
The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
{zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia.
Prostatic Hyperplasia
VAT-1 is a novel pathogenic factor of progressive benign prostatic hyperplasia.
Prostatic Neoplasms
VAT-1 is a novel pathogenic factor of progressive benign prostatic hyperplasia.
Sarcoma
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.
Urinary Bladder Neoplasms
A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9.