1.6.5.10: NADPH dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about NADPH dehydrogenase (quinone), go to the full flat file.
Word Map on EC 1.6.5.10
-
1.6.5.10
-
neutrophil
-
endothelial
-
p47phox
-
phagocyte
-
apocynin
-
dismutase
-
artery
-
gp91phox
-
cardiovascular
-
nicotinamide
-
hypertension
-
angiotensin
-
catalase
-
oxidases
-
cardiac
-
leukocyte
-
phorbol
-
monocyte
-
mapks
-
sod
-
aortic
-
granulomatous
-
diphenyleneiodonium
-
diphenylene
-
pma
-
iodonium
-
rac1
-
atherosclerosis
-
chemiluminescence
-
phagocytosis
-
xanthine
-
polymorphonuclear
-
myristate
-
microglial
-
myeloperoxidase
-
ii-induced
-
dihydroethidium
-
endothelium-dependent
-
flavocytochrome
-
zymosan
-
peroxynitrite
-
phagosomes
-
tempol
-
fmlp
-
ros-dependent
-
microbicidal
-
nadph-oxidase
-
nitrotyrosine
-
lucigenin
-
medicine
-
fmlp-induced
- 1.6.5.10
- neutrophil
- endothelial
- p47phox
- phagocyte
- apocynin
- dismutase
- artery
- gp91phox
- cardiovascular
- nicotinamide
- hypertension
- angiotensin
- catalase
- oxidases
- cardiac
- leukocyte
-
phorbol
- monocyte
- mapks
- sod
- aortic
- granulomatous
- diphenyleneiodonium
-
diphenylene
- pma
- iodonium
- rac1
- atherosclerosis
-
chemiluminescence
-
phagocytosis
- xanthine
-
polymorphonuclear
- myristate
- microglial
- myeloperoxidase
-
ii-induced
- dihydroethidium
-
endothelium-dependent
-
flavocytochrome
- zymosan
- peroxynitrite
-
phagosomes
-
tempol
- fmlp
-
ros-dependent
-
microbicidal
- nadph-oxidase
-
nitrotyrosine
- lucigenin
- medicine
-
fmlp-induced
Reaction
Synonyms
AKR1C9, ArsH, azoreductase, CBR4, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate (quinone), EC 1.6.99.6, MdaB, More, NADPH oxidase, NADPH quinone oxidoreductase, NADPH quinone oxidoreductase 1, NADPH quinone reductase, NADPH-dependent quinone reductase, NADPH-quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NQO1, PA1225, PpAzoR, XAC2229, Zta1p
ECTree
1.6.5.10 NADPH dehydrogenase (quinone)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.6.5.10 - NADPH dehydrogenase (quinone)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R,S)-camphorquinone + NADPH + H+
(R,S)-camphorquinone + NADP+
-
-
-
?
2,3-dimethoxy-5-methyl-1,4-benzoquinone + NADPH + H+
2,3-dimethoxy-5-methyl-1,4-benzoquinol + NADP+
-
-
-
-
?
2,6-dimethoxy-1,4-benzoquinone + NADPH + H+
2,6-dimethoxy-1,4-benzoquinol + NADP+
-
-
-
?
2-methyl-5-hydroxy-1,4-naphthoquinone + NADPH + H+
2-methyl-5-hydroxy-1,4-naphthoquinol + NADP+
-
-
-
-
?
5-hydroxy-2-methyl-1,4-naphthoquinone + NADPH + H+
5-hydroxy-2-methyl-1,4-naphthoquinol + NADP+
-
-
-
-
?
benzoquinone + NADPH
benzohydroquinone + NADP+
-
specific for NADPH
-
-
?
dichlorophenolindophenol + NADPH + H+
? + NADP+
-
about 15% of the activity with menadione
-
-
?
menadione + NADPH + H+
? + NADP+
-
two-electron transfer mechanism from NADPH to quinone
-
-
?
NADH + Fe(CN)63-
NAD+ + Fe(CN)63-
-
with NADH the actuvity is less than 10% of the activity with NADPH
-
-
?
NADH + H+ + 1,4-naphthoquinone
NAD+ + 1,4-naphthoquinol
-
with NADH the activity is about 15% of the activity with NADPH
-
-
?
NADH + H+ + coenzyme Q0
NAD+ + reduced coenzyme Q0
-
with NADH the activity is less than 10% of the activity with NADPH
-
-
?
NADH + H+ + coenzyme Q1
NAD+ + reduced coenzyme Q1
-
with NADH the activity is less than 10% of the activity with NADPH
-
-
?
NADH + H+ + dichlorophenolindophenol
NAD+ + reduced dichlorophenolindophenol
-
with NADH the actuvity is about 15% of the activity with NADPH
-
-
?
NADH + menadione
NAD+ + ?
-
with NADH the activity is less than 10% of the activity with NADPH
-
-
?
NADPH + H+ + 1,4-benzoquinone
NADP+ + 1,4-benzohydroquinol
no activity with NADH
-
-
?
NADPH + H+ + 2,3-dichloro-5,6-dicyano-1,4-benzoquinone
NADP+ + 2,3-dichloro-5,6-dicyano-1,4-benzoquinol
-
-
-
?
NADPH + H+ + 2,5-dimethyl-4-benzoquinone
NADP+ + 2,5-dimethyl-4-benzoquinonl
-
-
-
-
?
NADPH + H+ + 2-hydroxy-1,4-naphthoquinone
NADP+ + 2-hydroxy-1,4-naphthoquinol
-
-
-
-
?
NADPH + H+ + dichlorophenolindophenol
NADP+ + reduced dichlorophenolindophenol
-
-
-
-
?
NADPH + H+ + methyl-p-benzoquinone
NADP+ + methyl-p-benzohydroquinone
-
-
-
?
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
NADP+ + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
NADPH + H+ + phenyl-1,4-benzoquinone
NADP+ + phenyl-1,4-benzoquinol
-
-
-
?
NADPH + H+ + quinone
NADP+ + ?
-
TNF alpha and LPS induce Nqo1 mRNA expression
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADPH + H+
reduced 2,6-dichlorophenolindophenol + NAD(P)+
-
very low activity with NADH
-
-
?
oxidized dichlorophenolindophenol + NADPH + H+
reduced dicholorophenolindophenol + NADP+
-
-
-
-
?
ubiquinone-0 + NADPH + H+
ubiquinol-0 + NADP+
-
two-electron transfer mechanism from NADPH to quinone
-
-
?
ubiquinone-1 + NADPH + H+
ubiquinol-1 + NADP+
-
two-electron transfer mechanism from NADPH to quinone
-
-
?
1,4-benzoquinone + NADPH + H+
1,4-benzoquinol + NADP+
-
about 81% of the activity with menadione
-
-
?
1,4-benzoquinone + NADPH + H+
1,4-benzoquinol + NADP+
-
1,4-benzoquinone is oxidized almost stoichiometric amount of NADPH, suggesting that it is reduced to its hydroquinone with a two-electron reduction mechanism
-
-
?
1,4-naphthoquinone + NADPH + H+
1,4-naphthoquinol + NADP+
-
about 85% of the activity with menadione
-
-
?
1,4-naphthoquinone + NADPH + H+
1,4-naphthoquinol + NADP+
-
two-electron transfer mechanism from NADPH to quinone
-
-
?
1,4-naphthoquinone + NADPH + H+
1,4-naphthoquinol + NADP+
-
1,4-naphthoquinone participates in the redox cycling in their reduction by this enzyme as evidenced by excess NADPH oxidation over quinone reduction. CBR4 may reduce 1,4-naphthoquinone in the two-electron reduction mechanism, but produces reactive superoxide and semiquinones through their redox cycling
-
-
?
1,4-naphthoquinone + NADPH + H+
1,4-naphthoquinol + NADP+
-
specific for NADPH
-
-
?
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
-
about 90% of the activity with menadione
-
-
?
2-methyl-1,4-naphthoquinone + NADPH + H+
2-methyl-1,4-naphthoquinol + NADP+
-
-
-
-
?
2-methyl-1,4-naphthoquinone + NADPH + H+
2-methyl-1,4-naphthoquinol + NADP+
-
i.e. menadione, specific for NADPH
-
-
?
5-hydroxy-1,4-naphthoquinone + NADPH + H+
5-hydroxy-1,4-naphthoquinol + NADP+
-
5-hydroxy-1,4-naphthoquinone participates in the redox cycling in their reduction by this enzyme as evidenced by excess NADPH oxidation over quinone reduction
-
-
?
5-hydroxy-1,4-naphthoquinone + NADPH + H+
5-hydroxy-1,4-naphthoquinol + NADP+
-
-
-
-
?
9,10-phenanthrenequinone + NADPH + H+
9,10-phenanthrenequinol + NADP+
-
9,10-phenanthrenequinone participates in the redox cycling in their reduction by this enzyme as evidenced by excess NADPH oxidation over quinone reduction. CBR4 may reduce 9,10-phenanthrenequinone in the two-electron reduction mechanism, but produces reactive superoxide and semiquinones through their redox cycling
-
-
?
9,10-phenanthrenequinone + NADPH + H+
9,10-phenanthrenequinol + NADP+
-
-
-
?
9,10-phenanthrenequinone + NADPH + H+
9,10-phenanthrenequinol + NADP+
-
-
-
-
?
menadione + NADPH + H+
menadiol + NADP+
-
reduction follows a two-electron-pathway
-
-
?
methyl p-benzoquinone + NADPH + H+
methyl p-benzoquinol + NADP+
-
-
-
?
methyl p-benzoquinone + NADPH + H+
methyl p-benzoquinol + NADP+
-
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
acceptor: ferric chloride
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
aceptor: 1,10-phenanthroline
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
2,3',6-trichlorophenolindophenol is reduced to leuco-2,3',6-trichlorophenolindophenol
-
-
?
NADPH + H+ + 1,2-naphthoquinone-4-sulfonate
NADP+ + ?
-
i.e. Lawsone
-
-
?
NADPH + H+ + 1,2-naphthoquinone-4-sulfonate
NADP+ + ?
-
i.e. Lawsone
-
-
?
NADPH + H+ + a quinone
NADP+ + a quinol
-
the catalytic cycle of ArsH consists of the acceptance of two electrons from NADPH to reduce the flavin cofactor (reductive half-reaction) and the transfer of these electrons to an acceptor (oxidative half-reaction)
-
-
?
phenyl 1,4-benzoquinone + NADPH + H+
phenyl 1,4-benzoquinol + NADP+
-
-
-
?
phenyl 1,4-benzoquinone + NADPH + H+
phenyl 1,4-benzoquinol + NADP+
-
-
-
?
additional information
?
-
-
the enzyme plays an important role in managing oxidative stress and contributes to successful colonization of the host
-
-
?
additional information
?
-
-
the enzyme exhibits NADPH-dependent reductase activity for o- and p-quinones, but not for other aldehydes and ketones. In vitro quinone reduction by CBR4 generates superoxide through the redox cycling, and suggest that the enzyme may be involved in the induction of apoptosis by cytotoxic 9,10-phenanthrenequinone
-
-
?
additional information
?
-
PA1225 does not react with methyl red and does not possess azoreductase activity and displays a negligible NADPH:O2 oxidase activity
-
-
-
additional information
?
-
-
PA1225 does not react with methyl red and does not possess azoreductase activity and displays a negligible NADPH:O2 oxidase activity
-
-
-
additional information
?
-
-
the bifunctional enzyme also shows activity with azo dyes and NAD(P)H as cofactor, cf. EC 1.7.1.6
-
-
?
additional information
?
-
-
the bifunctional enzyme also shows activity with azo dyes and NAD(P)H as cofactor, cf. EC 1.7.1.6
-
-
?
additional information
?
-
enzyme displays bifunctional 3alpha-hydroxysteroid dehydrogenase and NADPH reductase (quinone) activities. Quinone reduction occurs via a mechanism that differs from 3-ketosteroid reduction. In this mechanism, the electron donor NADPH and acceptor o-quinone are bound in close proximity, which permits hydride transfer without formal protonation of the acceptor carbonyl by Tyr 55
-
-
?
additional information
?
-
-
trace activity with substrates acrolein, cinnamaldehyde, 3-buten-2-one, 3-penten-2-one, 3-nonen-2-one
-
-
?
additional information
?
-
-
NADH, deazariboflavin, and methylviologen can also act as electron donors
-
-
?
