1.5.8.3: sarcosine dehydrogenase
This is an abbreviated version!
For detailed information about sarcosine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.8.3
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1.5.8.3
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dimethylglycine
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sarcosinemia
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folate-binding
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dmgdh
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l-pipecolic
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pipox
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medicine
- 1.5.8.3
- dimethylglycine
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sarcosinemia
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folate-binding
- dmgdh
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l-pipecolic
- pipox
- medicine
Reaction
Synonyms
EC 1.5.99.1, monomethylglycine dehydrogenase, sarcosine N-demethylase, sarcosine:(acceptor) oxidoreductase (demethylating), sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating), SARDH, SDH
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General Information
General Information on EC 1.5.8.3 - sarcosine dehydrogenase
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malfunction
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reducing the expression of the enzyme promotes localization of TMEFF2 to the cytoskeleton and also results in increased cellular invasion in tumorigenesis
metabolism
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TMEFF2 interacts with SARDH and regulates the cellular levels of sarcosine. The tumor suppressor activity of TMEFF2 requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine
additional information
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the enzyme interacts with the full-length follistatin motifs 2, TMEFF2. TMEFF2 has a dual mode of action. The ectodomain does not bind to SARDH. Ectopic expression of wild-type full-length TMEFF2 inhibits soft agar colony formation, cellular invasion, and migration and increases cellular sensitivity to apoptosis. Expression of the full-length TMEFF2 but not the ectodomain results in a decreased level of sarcosine in the cells