1.5.3.13: N1-acetylpolyamine oxidase
This is an abbreviated version!
For detailed information about N1-acetylpolyamine oxidase, go to the full flat file.
Word Map on EC 1.5.3.13
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1.5.3.13
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spermine
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putrescine
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diamine
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ornithine
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oxidases
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n1-acetyltransferase
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s-adenosylmethionine
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n1-acetylspermine
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fad-dependent
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monoamine
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3-aminopropanal
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1,3-diaminopropane
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cadaverine
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apoplastic
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aminoaldehydes
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aminoguanidine
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acrolein
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back-conversion
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alpha-difluoromethylornithine
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samdc
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n1-acetylated
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thermospermine
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norspermidine
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n8-acetylspermidine
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tetraamine
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1.4.3.6
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analysis
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medicine
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pharmacology
- 1.5.3.13
- spermine
- putrescine
-
diamine
- ornithine
- oxidases
-
n1-acetyltransferase
- s-adenosylmethionine
- n1-acetylspermine
-
fad-dependent
-
monoamine
- 3-aminopropanal
- 1,3-diaminopropane
- cadaverine
- apoplastic
- aminoaldehydes
- aminoguanidine
- acrolein
-
back-conversion
- alpha-difluoromethylornithine
- samdc
-
n1-acetylated
- thermospermine
- norspermidine
- n8-acetylspermidine
-
tetraamine
-
1.4.3.6
- analysis
- medicine
- pharmacology
Reaction
Synonyms
APAO, AtPAO5, Bjpao2, EC 1.5.3.11, HPAO, hPAO-1, More, MPAO, N1-acetyl polyamine oxidase, N1-acetylpolyamine oxidase, PAO, PAO5, PAOh1, PAOX, polyamine oxidase, SelPAO5
ECTree
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Systematic Name
Systematic Name on EC 1.5.3.13 - N1-acetylpolyamine oxidase
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N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming)
The enzyme also catalyses the reaction: N1,N12-diacetylspermine + O2 + H2O = N1-acetylspermidine + 3-acetamamidopropanal + H2O2 [1]. No or very weak activity with spermine, or spermidine in absence of aldehydes. In presence of aldehydes the enzyme catalyses the reactions: 1. spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2, and with weak efficiency 2. spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [2]. A flavoprotein (FAD). This enzyme, encoded by the PAOX gene, is found in mammalian peroxisomes and oxidizes N1-acetylated polyamines at the exo (three-carbon) side of the secondary amine, forming 3-acetamamidopropanal. Since the products of the reactions are deacetylated polyamines, this process is known as polyamine back-conversion. Differs in specificity from EC 1.5.3.14 [polyamine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.15 [N8-acetylspermidine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase).