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1.5.3.10: dimethylglycine oxidase

This is an abbreviated version!
For detailed information about dimethylglycine oxidase, go to the full flat file.

Word Map on EC 1.5.3.10

Reaction

N,N-dimethylglycine
+
5,6,7,8-tetrahydrofolate
+
O2
=
sarcosine
+
5,10-methylenetetrahydrofolate
+
H2O2

Synonyms

dimethylglycine dehydrogenase, dmg, DMGO, DMGO1, DMGO2, N,N-dimethylglycine:oxygen oxidoreductase (demethylating)

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.10 dimethylglycine oxidase

Engineering

Engineering on EC 1.5.3.10 - dimethylglycine oxidase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D552A
-
mutation leads to increased formaldehyde release
H225Q
Y259F
additional information
-
complete removal of 5,10-CH2-THF synthase domain through expression of a truncated version generates a mutant enzyme unable to avoid hydrolysis of the imine species generated following amine oxidation