1.5.1.7: saccharopine dehydrogenase (NAD+, L-lysine-forming)
This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NAD+, L-lysine-forming), go to the full flat file.
Reaction
+
+
=
+
+
+
Synonyms
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming), epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming), Fvsdh, LYS1, Lys1p, Lysine--2-oxoglutarate reductase, lysine-2-oxoglutarate reductase, N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming), N6-(glutaryl-2)-L-lysine: NAD oxidoreductase, N6-(glutaryl-2)-L-lysine: NAD+ oxidoreductase, N6-(glutaryl-2)-l-lysine:NAD oxidoreductase, N6-(glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming), N6-(glutaryl-2)-L-lysine:NAD-oxidoreductase (L-lysine-forming), N6-(glutaryl-2)-L-lysine:nicotinamide adenine dinucleotide (NAD+) oxidoreductase (L-lysine-forming), NAD+-linked saccharopine dehydrogenase, saccharopine dehydrogenase, saccharopine dehydrogenase (L-lysine-forming), SDH
ECTree
Inhibitors
Inhibitors on EC 1.5.1.7 - saccharopine dehydrogenase (NAD+, L-lysine-forming)
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2,3-Butanedione
-
protection by L-leucine, NADH and 2-oxoglutarate
5,5'-dithiobis(2-nitrobenzoate)
-
-
alpha-ketoisovalerate
-
-
lysine
-
substrate inhibition
NADP+
-
NADP+ is competitive versus NADPH when NADPH serves as the coenzyme
p-chloromercuribenzoate
-
-
pyridine 2,3-dicarboxylate
-
-
Pyridine 2,4-dicarboxylate
-
-
pyridoxal 5'-phosphate
-
reversible inactivation
saccharopine
-
product inhibition, uncompetitive versus NADH
2-oxoglutarate
-
substrate inhibition
adenosine
-
slight
ADP
-
-
alpha-ketoglutarate
-
substrate inhibition, uncompetitive versus NADH
amino acids
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hydrophobic amino acids with 5 or 6 carbon atoms; hydroxylic amino acids
amino acids
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hydrophobic amino acids with 5 or 6 carbon atoms; not: dicarboxylic amino acids, aspartate, glutamate, 2-aminoadipate
AMP
-
-
iodoacetate
-
not
iodoacetate
-
NAD+ and NADH protect
L-isoleucine
-
-
L-leucine
-
-
L-leucine
-
L-leucine is a competitive inhibitor against L-lysine at pH 6.5-12.5
L-leucine
-
dead-end inhibition by L-leucine is uncompetitive versus NADPH
L-lysine
-
substrate inhibition, competitive versus NADH
L-norleucine
-
-
L-ornithine
-
-
NADH
-
not
NADH
-
substrate inhibition
oxalylglycine
-
at pH 5.45 and 9.58, oxalylglycine is competitive versus 2-oxoglutarate
oxalylglycine
-
competitive against lysine with mutant E78A, noncompetitive with mutants E78Q, E122Q, E78Q/E122Q, E122A, E78A/E122A
p-hydroxymercuribenzoate
-
NAD+ protects
p-hydroxymercuribenzoate
-
inhibition counteracted by 2-mercaptoethanol or glutathione
additional information
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no substrate inhibition by NADH, NAD+ and saccharopine
-
additional information
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detailed analysis of inhibition patterns for product and dead end inhibitors
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additional information
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not inhibited by L-asparagine at pH 7.0
-