1.5.1.43: carboxynorspermidine synthase
This is an abbreviated version!
For detailed information about carboxynorspermidine synthase, go to the full flat file.
Reaction
Synonyms
ASA-DAP Schiff base reductase, Atu4170, C-NSPD synthase, CANSDH, carboxy(nor)spermidine dehydrogenase, carboxynorspermidine dehydrogenase, carboxynorspermidine synthase, carboxyspermidine dehydrogenase, CASDH, VC1624
ECTree
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Systematic Name
Systematic Name on EC 1.5.1.43 - carboxynorspermidine synthase
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carboxynorspermidine:NADP+ oxidoreductase
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3].