1.5.1.34: 6,7-dihydropteridine reductase

This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.

Reaction

Synonyms

7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.34 6,7-dihydropteridine reductase

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Results	in table
1596	AA Sequence
2	Application
2	CAS Registry Number
15	Cloned(Commentary)
89	Cofactor
7	Crystallization (Commentary)
719	Disease/ Diagnostics
1	Expression
12	General Information
5	General Stability
1	IC50 Value
161	Inhibitors
52	Ki Value [mM]
194	KM Value [mM]
4	Localization
48	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
108	Organism
6	Pathway
29	PDB ID
13	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
30	Protein Variants
35	Purification (Commentary)
4	Reaction
3	Reaction Type
86	Reference
70	Source Tissue
40	Specific Activity [micromol/min/mg]
6	Storage Stability
131	Substrates and Products (Substrate)
29	Subunits
43	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
65	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.5.1.34 - 6,7-dihydropteridine reductase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(R)-2,10,11-trihydroxy-N-n-propylaporphine

2 entries

(R)-2,10,11-trihydroxyaporphine

2 entries

(R)-2,11-dihydroxy-10-methoxy-aporphine

2 entries

(R)-apocodeine

2 entries

(R)-apomorphine

2 entries

(R)-N-chloroethylnorapomorphine

2 entries

(R)-N-hydroxyethylnorapomorphine

2 entries

(R)-N-n-propylaporphine

2 entries

(R)-N-n-propylnorapomorphine

2 entries

(R)-norapomorphine

2 entries

(S)-2,10,11-trihydroxyaporphine

2 entries

(S)-bulbocapnine

2 entries

(S)-N-n-propylnorapomorphine

2 entries

1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine

2 entries

1-methyl-4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

2 entries

1-methyl-4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine

2 entries

1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

2 entries

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

2 entries

2,4-diamino-7,8-dihydropteroylglutamic acid

Rattus norvegicus

-

-

484996

2,4-Diaminopteridine

Rattus norvegicus

-

-

484996

2,4-diaminopteroic acid

Rattus norvegicus

-

-

484996

2,4-diaminopteroylglutamic acid

Rattus norvegicus

-

-

484996

2,6-dichlorophenolindophenol

2 entries

3',4'-deoxynorlaudanosolinecarboxylic acid

Homo sapiens

-

noncompetitive vs. quinoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine and NADH

484988

3(4-hydroxyphenyl)pyruvate

2 entries

3-iodotyrosine

Homo sapiens

-

weak inhibition

484984

3-O-methyldopamine

Homo sapiens

-

0.06 mM, 50% inhibition

484984

3-O-Methylepinephrine

Homo sapiens

-

0.18 mM, 50% inhibition

484984

3-phenylpyruvic acid

2 entries

4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine

2 entries

4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

2 entries

4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine

2 entries

4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

2 entries

4-hydroxyphenyllactate

2 entries

4-O-Methyldopamine

Homo sapiens

-

0.069 mM, 50% inhibition

484984

4-phenyl-1,2,3,6-tetrahydropyridine

2 entries

4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol

2 entries

5,5'-dithiobis(2-nitrobenzoate)

3 entries

5-Hydroxydopamine

Homo sapiens

-

0.042 mM, 50% inhibition

484984

6-Hydroxydopamine

Homo sapiens

-

0.029 mM, 50% inhibition

484984

Adrenochrome

Homo sapiens

-

-

484978

alpha-Methyltyrosine

Homo sapiens

-

1.1 mM, 50% inhibition

484984

aminochrome

Homo sapiens

-

oxidation product of adrenaline, competitive vs. NADH

484978

aminopterin

10 entries

catecholamine

Homo sapiens

-

-

484984

CdCl2

Pseudomonas sp.

-

0.1 mM, complete inactivation

484963

cis-Diaminodichloroplatinum

Homo sapiens

-

-

484985

CoCl2

Homo sapiens

-

0.01 mM, 30% inhibition

484993

dopachrome

Homo sapiens

-

0.6 mM, 50% inhibition

484987

dopamine

4 entries

epinephrine

Homo sapiens

-

0.13 mM, 50% inhibition

484984

H2O2

Homo sapiens

P09417

regulatory function in vivo, above 0.03 mM, oxidation of Met146 and Met151 leads to inactivation of the enzyme due to disruption of the NADH-binding site

656444

HgCl2

3 entries

higenamine

Homo sapiens

-

noncompetitive vs. quinoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine and NADH

484988

higenamine-1-carboxylic acid

Homo sapiens

-

noncompetitive vs. quinoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine

484988

iodoacetamide

Homo sapiens

-

-

484993

K2PtCl4

Homo sapiens

-

0.208 mM, half-life of inactivation: 3.1 min, NADH and 2 mM dithiothreitol completely protect

484985

L-beta-3,4-dihydroxyphenylalanine

4 entries

L-thyroxine

Bos taurus

-

mixed-type inhibition

485000

L-tyrosine

3 entries

m-tyramine

2 entries

methopterin

4 entries

methotrexate

4 entries

MgCl2

Pseudomonas sp.

-

0.1 mM, complete inactivation

484963

MnCl2

Pseudomonas sp.

-

0.1 mM, complete inactivation

484963

N-bromosuccinimide

Rattus norvegicus

-

-

484976

N-ethylmaleimide

2 entries

N-Methyldopamine

Homo sapiens

-

0.027 mM, 50% inhibition

484984

NAD+

Ovis aries

-

competitive vs. NADH

484962

NADP+

Bos taurus

-

competitive vs. NADPH

484960, 485000

noradrenaline

Rattus norvegicus

-

-

484974

norepinephrine

Homo sapiens

-

0.2 mM, 50% inhibition

484984

o-hydroxyphenylacetic acid

2 entries

octopamine

Homo sapiens

-

0.19 mM, 50% inhibition

484984

p-chloromercuribenzoate

4 entries

phenylacetic acid

2 entries

phenylalanine

Rattus norvegicus

-

-

484974

Phenyllactate

Rattus norvegicus

-

-

484974

phenylpyruvate

2 entries

quinonoid 2,4-diamino-7,8-dihydropteroylglutamic acid

Rattus norvegicus

-

-

484996

quinonoid 6,6,8-trimethyl-7,8-dihydro(6H)pterin

Ovis aries

-

0.2 mM, 50% inhibition

484982

quiononoid 2,4-diamino-7,8-dihydropteroylglutamic acid

Rattus norvegicus

-

-

484996

salsolinol

Homo sapiens

-

noncompetitive vs. quinoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine

484988

serotonin

Rattus norvegicus

-

-

484974

tetrahydrobiopterin

Homo sapiens

-

above 0.05 mM, substrate inhibition

484993

trans-Diaminodichloroplatinum

Homo sapiens

-

-

484985

trans-Pt(NH3)Cl2

Homo sapiens

-

1 mM, 96% inactivation after 2 h

484985

tryptophan

Rattus norvegicus

-

-

484974

tyramine

3 entries

[4-hydroxyphenyl]acetic acid

Homo sapiens

-

-

484979

additional information

3 entries

-

(R)-2,10,11-trihydroxy-N-n-propylaporphine

Homo sapiens

-

0.0017 mM, 50% inhibition

484981

(R)-2,10,11-trihydroxy-N-n-propylaporphine

Rattus norvegicus

-

0.0016 mM, 50% inhibition

484981

(R)-2,10,11-trihydroxyaporphine

Homo sapiens

-

0.0016 mM, 50% inhibition

484981

(R)-2,10,11-trihydroxyaporphine

Rattus norvegicus

-

0.0007 mM, 50% inhibition

484981

(R)-2,11-dihydroxy-10-methoxy-aporphine

Homo sapiens

-

0.013 mM, 50% inhibition

484981

(R)-2,11-dihydroxy-10-methoxy-aporphine

Rattus norvegicus

-

0.016 mM, 50% inhibition

484981

(R)-apocodeine

Homo sapiens

-

0.079 mM, 50% inhibition

484981

(R)-apocodeine

Rattus norvegicus

-

0.087 mM, 50% inhibition

484981

(R)-apomorphine

Homo sapiens

-

0.002 mM, 50% inhibition

484981

(R)-apomorphine

Rattus norvegicus

-

0.0012 mM, 50% inhibition

484981

(R)-N-chloroethylnorapomorphine

Homo sapiens

-

0.0029 mM, 50% inhibition

484981

(R)-N-chloroethylnorapomorphine

Rattus norvegicus

-

0.0029 mM, 50% inhibition

484981

(R)-N-hydroxyethylnorapomorphine

Homo sapiens

-

0.001 mM, 50% inhibition

484981

(R)-N-hydroxyethylnorapomorphine

Rattus norvegicus

-

0.0013 mM, 50% inhibition

484981

(R)-N-n-propylaporphine

Homo sapiens

-

-

484981

(R)-N-n-propylaporphine

Rattus norvegicus

-

-

484981

(R)-N-n-propylnorapomorphine

Homo sapiens

-

0.0018 mM, 50% inhibition

484981

(R)-N-n-propylnorapomorphine

Rattus norvegicus

-

0.0017 mM, 50% inhibition

484981

(R)-norapomorphine

Homo sapiens

-

0.0028 mM, 50% inhibition

484981

(R)-norapomorphine

Rattus norvegicus

-

0.0014 mM, 50% inhibition

484981

(S)-2,10,11-trihydroxyaporphine

Homo sapiens

-

0.0015 mM, 50% inhibition

484981

(S)-2,10,11-trihydroxyaporphine

Rattus norvegicus

-

0.0014 mM, 50% inhibition

484981

(S)-bulbocapnine

Homo sapiens

-

0.148 mM, 50% inhibition

484981

(S)-bulbocapnine

Rattus norvegicus

-

0.151 mM, 50% inhibition

484981

(S)-N-n-propylnorapomorphine

Homo sapiens

-

0.0022 mM, 50% inhibition

484981

(S)-N-n-propylnorapomorphine

Rattus norvegicus

-

0.0018 mM, 50% inhibition

484981

1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.0034 mM, 50% inhibition

484980

1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

1-methyl-4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.0093 mM, 50% inhibition

484980

1-methyl-4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

1-methyl-4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.27 mM, 50% inhibition

484980

1-methyl-4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.003 mM, 50% inhibition

484980

1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.3 mM, 50% inhibition

484980

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

2,6-dichlorophenolindophenol

Bos taurus

-

0.0001 mM, 50% inhibition

484960

2,6-dichlorophenolindophenol

Bos taurus

-

inhibition of NADPH-specific enzyme

485000

3(4-hydroxyphenyl)pyruvate

Homo sapiens

-

0.0033 mM, 50% inhibition

484979

3(4-hydroxyphenyl)pyruvate

Ovis aries

-

0.0044 mM, 50% inhibition

484979

3-phenylpyruvic acid

Homo sapiens

-

4.7 mM, 50% inhibition

484979

3-phenylpyruvic acid

Ovis aries

-

5.9 mM, 50% inhibition

484979

4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.0036 mM, 50% inhibition

484980

4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.0072 mM, 50% inhibition

484980

4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.34 mM, 50% inhibition

484980

4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

Homo sapiens

-

0.0059 mM, 50% inhibition

484980

4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

4-hydroxyphenyllactate

Homo sapiens

-

0.058 mM, 50% inhibition

484979

4-hydroxyphenyllactate

Ovis aries

-

0.071 mM, 50% inhibition

484979

4-phenyl-1,2,3,6-tetrahydropyridine

Homo sapiens

-

12 mM, 50% inhibition

484980

4-phenyl-1,2,3,6-tetrahydropyridine

Rattus norvegicus

-

-

484980

4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol

Homo sapiens

-

no inhibition below 0.2 mM

484978

4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol

Rattus norvegicus

-

-

484974

5,5'-dithiobis(2-nitrobenzoate)

Homo sapiens

-

0.1 mM, 60% inhibition

484993

5,5'-dithiobis(2-nitrobenzoate)

Pseudomonas sp.

-

0.57 mM, 98% inhibition

484963

5,5'-dithiobis(2-nitrobenzoate)

Rattus norvegicus

-

no inactivation in the presence of NADH

484976

aminopterin

Bos taurus

-

0.025 mM, 50% inhibition of NADH-specific enzyme, 1 mM, 50% inhibition of NADPH-specific enzyme

484959

aminopterin

Bos taurus

-

1 mM, 50% inhibition, NADPH-specific enzyme

484960

aminopterin

Bos taurus

-

no inhibition up to 0.1 mM

484990

aminopterin

Bos taurus

-

0.025 mM, 50% inhibition of NADH-specific enzyme, 1 mM, 50% inhibition of NADPH-specific enzyme

485000

aminopterin

Crithidia fasciculata

-

1 mM, 50% inhibition

484992

aminopterin

Homo sapiens

-

-

484988

aminopterin

Homo sapiens

P09417

the DHFR inhibitor aminopterin inhibits tetrahydrobiopterin recycling. Aminopterin has no effect alone but slightly reduced L-citrulline formation and cGMP accumulation in the presence of dihydrobiopterin

741864

aminopterin

Ovis aries

-

-

484958

aminopterin

Pseudomonas sp.

-

competitive vs. 2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine

484963

aminopterin

Sus scrofa

Q8MJ30

the DHFR inhibitor aminopterin inhibits tetrahydrobiopterin recycling. Aminopterin has no effect alone but slightly reduced L-citrulline formation and cGMP accumulation in the presence of dihydrobiopterin

741864

dopamine

Homo sapiens

-

no inhibition below 0.2 mM

484978

dopamine

Homo sapiens

-

-

484984

dopamine

Homo sapiens

-

noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine

484988

dopamine

Rattus norvegicus

-

0.1 mM, 50% inhibition

484973

HgCl2

Homo sapiens

-

0.0001 mM, 60% inhibition

484993

HgCl2

Ovis aries

-

0.002 mM, 50% inhibition, enzyme from brain

484962

HgCl2

Pseudomonas sp.

-

-

484963

L-beta-3,4-dihydroxyphenylalanine

Homo sapiens

-

0.23 mM, 50% inhibition

484979

L-beta-3,4-dihydroxyphenylalanine

Homo sapiens

-

0.02 mM, 50% inhibition

484984

L-beta-3,4-dihydroxyphenylalanine

Homo sapiens

-

0.8 mM, 50% inhibition after 3 h, 80% inhibition after 16 h due to oxidation of L-DOPA to dopachrome which inhibits the enzyme

484987

L-beta-3,4-dihydroxyphenylalanine

Ovis aries

-

trivial name L-DOPA, 0.34 mM, 50% inhibition

484979

L-tyrosine

Bos taurus

-

noncompetitive vs. NADPH

484960

L-tyrosine

Homo sapiens

-

0.44 mM, 50% inhibition

484979, 484984

L-tyrosine

Ovis aries

-

0.61 mM, 50% inhibition

484979

m-tyramine

Homo sapiens

-

0.036 mM, 50% inhibition

484979

m-tyramine

Ovis aries

-

0.044 mM, 50% inhibition

484979

methopterin

Bos taurus

-

0.038 mM, 50% inhibition of NADH-specific enzyme

484959

methopterin

Bos taurus

-

0.7 mM, 50% inhibition of NADPH-specific enzyme

484960

methopterin

Bos taurus

-

0.038 mM, 50% inhibition of NADH-specific enzyme; 0.7 mM, 50% inhibition of NADPH-specific enzyme

485000

methopterin

Crithidia fasciculata

-

1 mM, 10% inhibition

484992

methotrexate

Bos taurus

-

no inhibition up to 0.1 mM

484990

methotrexate

Escherichia coli

-

competitive vs. quinoid 6-methyl-7,8-dihydropterin

484997

methotrexate

Ovis aries

-

-

484958, 484995

methotrexate

Rattus norvegicus

-

-

485008

N-ethylmaleimide

Homo sapiens

-

1 mM, 76% inhibition

484993

N-ethylmaleimide

Pseudomonas sp.

-

5 mM, complete inhibition of reduced enzyme

484963

o-hydroxyphenylacetic acid

Homo sapiens

-

6.9 mM, 50% inhibition

484979

o-hydroxyphenylacetic acid

Ovis aries

-

8.1 mM, 50% inhibition

484979

p-chloromercuribenzoate

Homo sapiens

-

0.01 mM, 70% inhibition

484993

p-chloromercuribenzoate

Ovis aries

-

0.2 mM, 50% inhibition, enzyme from brain

484962

p-chloromercuribenzoate

Pseudomonas sp.

-

0.4 mM, 50% inhibition

484963

p-chloromercuribenzoate

Rattus norvegicus

-

complete inactivation at inhibitor/enzyme ratios greater than 6/1, NADH protects

484976

phenylacetic acid

Homo sapiens

-

6.6 mM, 50% inhibition

484979

phenylacetic acid

Ovis aries

-

6.9 mM, 50% inhibition

484979

phenylpyruvate

Homo sapiens

-

-

484988

phenylpyruvate

Rattus norvegicus

-

-

484974

tyramine

Homo sapiens

-

0.04 mM, 50% inhibition

484979

tyramine

Homo sapiens

-

IC50: 0.04 mM

484984

tyramine

Ovis aries

-

0.046 mM, 50% inhibition

484979

additional information

Bos taurus

-

enzyme from adrenal medulla, not inhibited by aminopterin and methotrexate

484990

-

additional information

Homo sapiens

-

quinone products of L-DOPA oxidation are responsible for the time-dependent inactivation of the enzyme

484987

-

additional information

Homo sapiens

-

not inhibited by EDTA, o-phenanthroline, and 2,2'-bipyridyl

484993

-