1.5.1.33: pteridine reductase

This is an abbreviated version!
For detailed information about pteridine reductase, go to the full flat file.

Reaction

Synonyms

Atu1130, EC 1.1.1.253, H region methotrexate resistance protein, LaPTR1, LbPTR1, LdPTR1, LmPTR1, LpPTR1, More, NADPH-dependent short-chain dehydrogenase/reductase pteridine reductase, NADPH-dihydropteridine reductase, PruA, pteridine reductase, pteridine reductase 1, pteridine reductase I, PTR1, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide phosphate), Tb-PR, TbPTR1, tcptr1

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.33 pteridine reductase

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Results	in table
720	AA Sequence
9	Application
1	CAS Registry Number
26	Cloned(Commentary)
44	Cofactor
12	Crystallization (Commentary)
5	Expression
53	General Information
81	IC50 Value
372	Inhibitors
13	kcat/KM [mM/s]
178	Ki Value [mM]
56	KM Value [mM]
4	Localization
15	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
73	Organism
2	Pathway
238	PDB ID
25	pH Optimum
5	pH Range
1	pH Stability
25	Protein Variants
13	Purification (Commentary)
5	Reaction
2	Reaction Type
65	Reference
4	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
128	Substrates and Products (Substrate)
22	Subunits
129	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Stability [°C]
17	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.5.1.33 - pteridine reductase

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SYSTEMATIC NAME

IUBMB Comments

5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase

The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH.