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1.5.1.33: pteridine reductase

This is an abbreviated version!
For detailed information about pteridine reductase, go to the full flat file.

Word Map on EC 1.5.1.33

Reaction

5,6,7,8-tetrahydrobiopterin
+ 2 NADP+ =
biopterin
 + 2 NADPH + 2 H+

Synonyms

Atu1130, EC 1.1.1.253, H region methotrexate resistance protein, LaPTR1, LbPTR1, LdPTR1, LmPTR1, LpPTR1, More, NADPH-dependent short-chain dehydrogenase/reductase pteridine reductase, NADPH-dihydropteridine reductase, PruA, pteridine reductase, pteridine reductase 1, pteridine reductase I, PTR1, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide phosphate), Tb-PR, TbPTR1, tcptr1

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.33 pteridine reductase

Cloned

Cloned on EC 1.5.1.33 - pteridine reductase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed as a His-tagged fusion protein
-
expressed as N-terminal His6-tagged protein in Spodoptera frugiperda 21 cells
expressed in Escherichia coli BL21 (DE3) GOLD cells
expressed in Escherichia coli strain JM109
expression in Escherichia coli
expression of GFP-tagged enzyme in Leishmania donovani
-
gene Atu1130, recombinant overexpression of N-terminally His6-tagged enzyme in Escherichia coli
gene ptr1 from wild-type and SbIII-resistant lines, DNA and amino acid sequenc determination, analysis, and comparison, chromosomal localization, enzyme expression analysis. PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts
gene ptr1 from wild-type and SbIII-resistant lines, DNA and amino acid sequenc determination, analysis, and comparison, chromosomal localization, enzyme expression analysis. PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts. Overexpression of ptr1 gene in the wild-type Leishmania braziliensis lines increases 2fold the SbIII-resistance phenotype compared to the non-transfected counterpart
gene ptr1 from wild-type and SbIII-resistant lines, DNA and amino acid sequenc determination, analysis, and comparison, chromosomal localization, enzyme expression analysis. PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts. Overexpression of ptr1 gene in the wild-type Leishmania infantum lines does not change the SbIII-resistance phenotype
gene PTR1, recombinant expression of His-tagged enzyme in Escherichia coli
gene PTR1, recombinant expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3)
-
gene ptr1, recombinant overexpression of N-terminally His6-tagged enzyme in Escherichia coli
overexpressed in transgenic Leishmania parasites as N-terminal GFP-tagged PTR1-green fluorescent protein
-
overexpression of the N-terminally His-tagged enzyme in Escherichia coli strain BL21(DE3)
promastigote form of Leishmania donovani transfected with GFP and GFP-PTR1 chimera
recombinantly expressed
transgenic parasites overexpress a PTR1-GFP chimera (PTR1 tagged at the N-terminal with GFP)
-