1.5.1.22: Strombine dehydrogenase
This is an abbreviated version!
For detailed information about Strombine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.1.22
Reaction
Synonyms
Dehydrogenase, strombine, SDH, St/AlDH1, St/AlDH2, St/AlDH3, StDH, STRDH, strombine dehydrogenase, strombine/alanopine dehydrogenase
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1.5.1.22 Strombine dehydrogenaseAdvanced search results
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Substrates Products on EC 1.5.1.22 - Strombine dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Gly + 2-ketobutyrate + NADH + H+
2-[(carboxymethyl)amino]butanoic acid + NAD+ + H2O
8.9% activity compared to Gly + pyruvate + NADH with isozyme St/AlDH1
-
-
?
Gly + glyoxylate + NADH + H+
[(carboxymethyl)amino]propanedioic acid + NAD+ + H2O
3.9% activity compared to Gly + pyruvate + NADH with isozyme St/AlDH1
-
-
?
Gly + oxaloacetate + NADH + H+
N-carboxymethylglycine + NAD+ + H2O
39.1% activity compared to Gly + pyruvate + NADH with isozyme St/AlDH1
-
-
?
Gly + pyruvate + NADH + H+
D-strombine + NAD+ + H2O
94.6% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
Gly + pyruvate + NADPH
D-strombine + NADP+ + H2O
less than 0.5% activity compared to Gly + pyruvate + NADH with isozyme St/AlDH1
-
-
?
glycine + pyruvate + NADH + H+
N-(carboxymethyl)-D-alanine + NAD+ + H2O
-
the reduction reaction is preferred
-
-
r
L-Ala + 2-ketobutyrate + NADH + H+
2-[[(1S)-1-carboxyethyl]amino]butanoic acid + NAD+ + H2O
8.9% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Ala + glyoxylate + NADH + H+
N-(carboxymethyl)-L-Ala + NAD+ + H2O
4.0% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Ala + oxaloacetate + NADH + H+
[[(1S)-1-carboxyethyl]amino]propanedioic acid + NAD+ + H2O
40.0% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Ala + pyruvate + NADH + H+
meso-alanopine + NAD+ + H2O
100% activity
-
-
?
L-Ala + pyruvate + NADPH
meso-alanopine + NADP+ + H2O
less than 0.5% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Cys + pyruvate + NADH + H+
N-(1-carboxyethyl)-L-Cys + NAD+ + H2O
1.7% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Ser + pyruvate + NADH + H+
N-(1-carboxyethyl)-L-Ser + NAD+ + H2O
14.2% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Val + pyruvate + NADH + H+
N-(1-carboxyethyl)-L-Val + NAD+ + H2O
0.9% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
additional information
?
-
-
the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia
-
-
?
Gly + 2-oxobutanoate + NADH
?
-
at 24.8% of the activity with pyruvate
-
-
?
Gly + pyruvate + NADH
D-Strombine + NAD+ + H2O
the enzyme is highly specific to glycine. No enzyme activity is observed when other amino acids (alanine and taurine) are used as substrates in the experiment
-
-
?
glycine + pyruvate + NADH
D-strombine + NAD+ + H2O
-
Gly and Ala are preferred substrates
-
-
?
glycine + pyruvate + NADH
D-strombine + NAD+ + H2O
enzyme is specific for glycine
-
-
?
L-2-Aminobutanoate + pyruvate + NADH
?
-
68.3% of the activity with Gly
-
-
?
L-2-Aminobutanoate + pyruvate + NADH
?
-
at 48% of the activity with Gly
-
-
?
L-Ala + pyruvate + NADH
meso-Alanopine + NAD+ + H2O
-
101% of the activity with Gly
-
-
?
L-Ala + pyruvate + NADH
meso-Alanopine + NAD+ + H2O
-
at 76% of the activity with Gly
-
-
?
L-Ala + pyruvate + NADH
meso-Alanopine + NAD+ + H2O
-
94% of the activity with Gly
-
-
?
L-Ala + pyruvate + NADH
meso-Alanopine + NAD+ + H2O
-
in the reverse reaction: 81% of the activity with meso-alanopine compared to strombine
-
?
