1.5.1.21: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
This is an abbreviated version!
For detailed information about 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), go to the full flat file.
Word Map on EC 1.5.1.21
Reaction
Synonyms
1,2-didehydropipecolate reductase, 1,2-didehydropipecolic reductase, CRYM, DELTA1-piperideine-2-carboxylate reductase, DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, DpkA, EC 1.5.1.14, ketimine reductase, L-pipecolate:NADP+ 2-oxidoreductase, lhpD, mu-crystallin, NAD(P)H-dependent DELTA1-pyrroline-2-carboxylate reductase, P2C reductase, P2C/Pyr2C reductase, PaLhpD, Pip2CR, Pyr2C reductase, Pyr2C/Pip2C reductase, reductase, DELTA 1-piperideine-2-carboxylate
ECTree
1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.5.1.21 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-pyrroline-(4R)-hydroxy-2-carboxylate + NADPH + H+
(4R)-hydroxy-L-proline + NADP+
-
-
-
r
alpha-ketobutanoate + methylamine + NADPH
N-methyl-2-aminobutanoate + NADP+ + H2O
10% of the rate with pyruvate
-
-
?
alpha-ketohexanoate + methylamine + NADPH
N-methyl-2-aminohexanoate + NADP+ + H2O
23% of the rate with pyruvate
-
-
?
cis-3-hydroxy-L-proline + NADPH + H+
? + NADP+
low activity
-
-
r
DELTA1-pyrroline-5-carboxylate + NADPH + H+
?
-
very little activity
-
-
r
fluoropyruvate + methylamine + NADPH
N-methylfluoroalanine + NADP+ + H2O
14% of the rate with pyruvate
-
-
?
L-pipecolate + NADP+
1-piperideine-2-carboxylate + NADPH + H+
the reaction equilibrium favors the direction toward NADPH-dependent reduction
-
-
r
L-proline + NADP+
1-pyrroline-2-carboxylate + NADPH + H+
the reaction equilibrium favors the direction toward NADPH-dependent reduction
-
-
r
phenylpyruvate + methylamine + NADPH
N-methylphenylalanine + NADP+ + H2O
6.3% of the rate with pyruvate
-
-
?
trans-3-hydroxy-L-proline + NADPH + H+
? + NADP+
moderate activity
-
-
r
1-piperideine-2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
r
1-piperideine-2-carboxylate + NADPH + H+
L-pipecolate + NADP+
the reaction equilibrium favors the direction toward NADPH-dependent reduction
-
-
r
1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
-
-
-
r
1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
the reaction equilibrium favors the direction toward NADPH-dependent reduction
-
-
r
cis-4-hydroxy-L-proline + NADPH + H+
? + NADP+
low activity
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
the equilibrium position lies far toward formation of the six-membered ring structure L-pipecolate at neutral pH
-
-
?
DELTA1-piperideine-2-carboxylate + NADH
L-pipecolate + NAD+
-
-
-
-
?
DELTA1-piperideine-2-carboxylate + NADPH
L-pipecolate + NADP+
-
-
-
-
?
DELTA1-piperideine-2-carboxylate + NADPH
L-pipecolate + NADP+
-
-
-
ir
DELTA1-piperideine-2-carboxylate + NADPH
L-pipecolate + NADP+
-
D-lysine metabolism
-
-
?
DELTA1-piperideine-2-carboxylate + NADPH
L-pipecolate + NADP+
NADH is a poor electron donor, lower activity in the reverse reaction direction
-
-
r
DELTA1-piperideine-2-carboxylate + NADPH
L-pipecolate + NADP+
NADH is a poor electron donor, lower activity in the reverse reaction direction
-
-
r
DELTA1-piperideine-2-carboxylate + NADPH
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine-2-carboxylate + NADPH
L-pipecolate + NADP+
-
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NADPH
L-proline + NADP+
NADH is a poor electron donor, lower activity in the reverse reaction direction
-
-
r
DELTA1-pyrroline-2-carboxylate + NADPH
L-proline + NADP+
NADH is a poor electron donor, lower activity in the reverse reaction direction
-
-
r
additional information
?
-
the same enzyme catalyzes the reduction of both DELTA1-piperideine-2-carboxylate and DELTA1-pyrrolidine-2-carboxylate, but is unable to catalyze the reduction of DELTA1-pyrroline-5-carboxylate and DELTA1-piperideine-6-carboxylate, which may be regarded as double bond positional isomers of DELTA1-piperideine-2-carboxylate and DELTA1-pyrrolidine-2-carboxylate, respectively
-
-
?
additional information
?
-
PaLhpD shows 32.8%, 14.4% and 12.2% activity for trans-3-hydroxy-L-proline, cis-4-hydroxy-L-proline, and cis-3-hydroxy-L-proline as a percent of L-proline in the oxidation reaction, respectively. Both L-proline and L-pipecolate undergo NADP+-dependent oxidization, but their kcat/Km values are 500 and 350fold lower than those with 1-pyrroline-2-carboxylate and 1-piperideine-2-carboxylate, respectively. No activity with trans-4-hydroxy-D-proline, D-proline, cis-4-hydroxy-D-proline, and cis-3-hydroxy-D-proline, poor activity with trans-4-hydroxy-L-proline
-
-
?
additional information
?
-
-
poor substrates: DELTA1-pyrroline-5-carboxylate, pyroglutamate
-
-
?
additional information
?
-
enzyme is involved in the catabolism of D-lysine and D-proline, pathway overview
-
-
?
additional information
?
-
-
enzyme is involved in the catabolism of D-lysine and D-proline, pathway overview
-
-
?
additional information
?
-
substrate specificity, enzyme shows no malate or lactate dehydrogenase activity
-
-
?
additional information
?
-
-
substrate specificity, enzyme shows no malate or lactate dehydrogenase activity
-
-
?
additional information
?
-
enzyme is involved in the catabolism of D-lysine and D-proline, pathway overview
-
-
?
additional information
?
-
substrate specificity, enzyme shows no malate or lactate dehydrogenase activity
-
-
?
additional information
?
-
no substrate: alpha-ketovalerate, ammonia
-
-
?
