Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
collagen + H2O + O2
allysyl-collagen + NH3 + H2O2
collagen III + O2 + H2O
allysyl-collagen III + NH3 + H2O2
-
-
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
[collagen]-L-lysine + O2 + H2O
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
[elastin]-L-lysine + O2 + H2O
[elastin]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix
-
-
?
additional information
?
-
collagen + H2O + O2
allysyl-collagen + NH3 + H2O2
-
-
-
?
collagen + H2O + O2
allysyl-collagen + NH3 + H2O2
-
the enzyme initiates the enzymatic stage of collagen and elastin cross-linking. Lysyl oxidase activity is essential for the integrity maintenance of the dermis and for the homeostasis of the epidermis. The LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
-
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
-
-
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
-
the enzyme initiates the enzymatic stage of collagen and elastin cross-linking. Lysyl oxidase activity is essential for the integrity maintenance of the dermis and for the homeostasis of the epidermis. The LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
deamination of lysyl and hydroxylysyl residues is part of the pyridinoline biosynthetic pathway, pyridinoline is involved in formation of intracellular and extracellular collagen cross-links responsible for aging of connective tissue
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
key enzyme in formation of lysine cross-links in side collagen and elastin molecules
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
substrates are proteins of the extracellular matrix
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
formation of cross-links in mature fibrillar collagen and elastin fibers in the extracellular space
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
initiation of covalent intermolecular cross-linking of collagen by the enzyme action on telopeptidyl lysine and hydroxylysine residues
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
[collagen]-L-lysine + O2 + H2O
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
-
-
-
?
[collagen]-L-lysine + O2 + H2O
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix
-
-
?
additional information
?
-
-
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments
-
-
?
additional information
?
-
-
the enzyme does not affect smooth muscle cell proliferation nor elastin precursor, tropoelastin, synthesis, nor total elastin synthesis in a per-cell-basis
-
-
?
additional information
?
-
-
critical role for lysyl oxidase in zebrafish notochord morphogenesis
-
-
?
additional information
?
-
LOX induced chromatin changes, mechanism via histone deamination
-
-
?
additional information
?
-
LOX induced chromatin changes, mechanism via histone deamination
-
-
?
additional information
?
-
lysyl oxidase gene family. Enzyme seems to be involved in binding and crosslinking to other cell-surface and extracellular-matrix proteins
-
-
?
additional information
?
-
-
lysyl oxidase gene family. Enzyme seems to be involved in binding and crosslinking to other cell-surface and extracellular-matrix proteins
-
-
?
additional information
?
-
-
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments, enzyme expression in downregulated in Menkes disease, a disorder of copper transport
-
-
?
additional information
?
-
-
LOX induced chromatin changes, mechanism via histone deamination
-
-
?
additional information
?
-
-
the enzyme forms are differently involved in tumor suppression, cellular senescence, and chemotaxis
-
-
?
additional information
?
-
-
potential role of lysyl oxidase/placental lactogen interactions in breast epithelial cell proliferation and migration
-
-
?
additional information
?
-
-
LOX is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin side chains and thereby contributes to extracellular matrix integrity
-
-
?
additional information
?
-
-
LOX is an extracellular matrix-remodeling enzyme involved in regulation of tumor metastasis
-
-
?
additional information
?
-
-
LOX secreted by hypoxic breast tumor cells accumulates at premetastatic sites, crosslinks collagen IV in the basement membrane, and is essential for CD11b+ myeloid cell recruitment. LOX inhibition prevents CD11b+ cell recruitment and metastatic growth. CD11b+ cells and LOX also colocalize in biopsies of human metastases, detailed overview
-
-
?
additional information
?
-
-
enzyme is responsible for the cross-linking of collagen and elastin, and is required for vascular and diaphragmatic development during embryogenesis
-
-
?
additional information
?
-
-
expression of isozymes LOXL1,3,4 during osteoblast differentiation is highly regulated due to their distinct roles in collagen matrix stabilization and subsequent mineralization
-
-
?
additional information
?
-
-
LOX is essential for collagen and elastin matrix stability and newborn animal survival
-
-
?
additional information
?
-
-
lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues
-
-
?
additional information
?
-
-
lysyl oxidase, an amine oxidase, is critical for the initiation of collagen and elastin cross-linking, binds transforming growth factor-beta, and regulates its signaling via amine oxidase activity, mechanism, overview. LOX suppresses TGF-beta1-induced Smad3 phosphorylation likely through its amine oxidase activity
-
-
?
additional information
?
-
-
the enzyme forms desmosine crosslinking structures in elastic fibers contributing to the elasticity
-
-
?
additional information
?
-
-
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments
-
-
?
additional information
?
-
-
lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix
-
-
?