1.4.1.12: 2,4-diaminopentanoate dehydrogenase

This is an abbreviated version!
For detailed information about 2,4-diaminopentanoate dehydrogenase, go to the full flat file.

Reaction

Synonyms

2,4-DAPDH, 2,4-diaminopentanoic acid C4 dehydrogenase, 2R,4S-2,4-diaminopentanoate dehydrogenase, DAPDH

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.12 2,4-diaminopentanoate dehydrogenase

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Results	in table
100	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
11	Cofactor
1	General Information
20	Inhibitors
5	kcat/KM [mM/s]
1	Ki Value [mM]
12	KM Value [mM]
2	Metals/Ions
7	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
7	Organism
6	Pathway
3	pH Optimum
2	pH Range
1	pH Stability
2	Purification (Commentary)
1	Reaction
3	Reaction Type
7	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
18	Substrates and Products (Substrate)
4	Subunits
4	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
6	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.4.1.12 - 2,4-diaminopentanoate dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)

Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].