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1.3.99.27: 1-hydroxycarotenoid 3,4-desaturase

This is an abbreviated version!
For detailed information about 1-hydroxycarotenoid 3,4-desaturase, go to the full flat file.

Reaction

1-hydroxy-1,2-dihydrolycopene
+
acceptor
=
1-hydroxy-3,4-didehydro-1,2-dihydrolycopene
+
reduced acceptor

Synonyms

1-HO carotenoid 3,4-dehydrogenase, 1-hydroxy monocyclic carotenoid 3,4-dehydrogenase, acyclic carotenoid 3,4-desaturase, CrtD, DDD_2394, hydroxyneurosporene desaturase, P99-3 CrtD

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.27 1-hydroxycarotenoid 3,4-desaturase

Substrates Products

Substrates Products on EC 1.3.99.27 - 1-hydroxycarotenoid 3,4-desaturase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1'-hydroxy-gamma-carotene + acceptor
1'-hydroxytorulene + reduced acceptor
show the reaction diagram
1,1'-dihydroxy-3,4-didehydrolycopene + acceptor
1,1'-dihydroxy-3,4,3',4'-tetradehydrolycopene + reduced acceptor
show the reaction diagram
-
38% conversion
-
-
?
1,1'-dihydroxyneurosporene + acceptor
1'-hydroxy-1-demethylspheroidene + reduced acceptor
show the reaction diagram
-
39% conversion
-
-
?
1-hydroxy-1,2-dihydrorhodopin + acceptor
1-hydroxy-3,4-didehydro-1,2-dihydrorhodopin + reduced acceptor
show the reaction diagram
1-hydroxy-3',4'-didehydrolycopene + acceptor
1-hydroxy-3,4,3',4'-tetradehydrolycopene + reduced acceptor
show the reaction diagram
-
28% conversion
-
-
?
1-hydroxy-3,4-didehydrolycopene + acceptor
1-hydroxy-3,4,3',4'-tetradehydrolycopene + reduced acceptor
show the reaction diagram
-
-
-
-
?
1-hydroxy-zeta-carotene + acceptor
1-hydroxy-3,4-didehydro-zeta-carotene + reduced acceptor
show the reaction diagram
-
15% conversion
-
-
?
1-hydroxylycopene + acceptor
1-hydroxy-3,4-didehydrolycopene + reduced acceptor
show the reaction diagram
1-hydroxyneurosporene + acceptor
1-demethylspheroidene + reduced acceptor
show the reaction diagram
-
47% conversion. The 3,4-desaturation reaction can only occur with mono-1-hydroxy carotenoids at a Psi-end group or with 1,1'-dihydroxy derivatives carrying a 3'4'-double bond. In addition, 1-hydroxy-zeta-carotene could also be converted by the desaturase. Enzyme kinetic studies show a substrate preference of 1-hydroxyneurosporene over 1-hydroxylycopene
-
-
?
1-hydroxyneurosporene + acceptor
demethylspheroidene + reduced acceptor
show the reaction diagram
-
when O2 is depleted less than 10% of the specific activity is retained. It is rather unlikely that molecular oxygen is the genuine cofactor for hydroxyneurosporene desaturation reactions in Rhodobacter cells when they reach their maximum carotenoid content under anaerobic conditions. Consequently, another, as-yet-unknown electron acceptor may exist in Rhodobacter species that replaces molecular oxygen during anaerobic growth
-
-
?
1-methoxy-1'-hydroxy-3,4-didehydrolycopene + acceptor
1-methoxy-1'-hydroxy-3,4,3',4'-tetradehydrolycopene + reduced acceptor
show the reaction diagram
-
37% conversion
-
-
?
additional information
?
-