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1.3.98.3: coproporphyrinogen dehydrogenase

This is an abbreviated version!
For detailed information about coproporphyrinogen dehydrogenase, go to the full flat file.

Word Map on EC 1.3.98.3

Reaction

Coproporphyrinogen III
+ 2 S-adenosyl-L-methionine =
protoporphyrinogen IX
 + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Synonyms

anaerobic coproporphyrinogen III oxidase, At5g63290, AtHEMN1, BtrN, CgoX, Coprogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogenase, CPO, EC 1.3.99.22, HemN, HEMN1, HemW, More, oxidase, coproporphyrinogen, oxygen-independent coproporphyrinogen III oxidase, oxygen-independent coproporphyrinogen-III oxidase, oxygen-independent CPO, radical S-adenosyl-L-methionine dehydrogenase, radical SAM enzyme, Sll1876, Sll1917, viperin

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.98 With other, known, physiological acceptors
                1.3.98.3 coproporphyrinogen dehydrogenase

Reference

topprint

Reference on EC 1.3.98.3 - coproporphyrinogen dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Layer, G.; Moser, J.; Heinz, D.W.; Jahn, D.; Schubert, W.D.
Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes
EMBO J.
22
6214-6224
2003
Escherichia coli (P32131), Escherichia coli
Manually annotated by BRENDA team
Layer, G.; Verfurth, K.; Mahlitz, E.; Jahn, D.
Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli
J. Biol. Chem.
277
34136-34142
2002
Escherichia coli
Manually annotated by BRENDA team
Layer, G.; Heinz, D.W.; Jahn, D.; Schubert, W.D.
Structure and function of radical SAM enzymes
Curr. Opin. Chem. Biol.
8
468-476
2004
Escherichia coli
Manually annotated by BRENDA team
Layer, G.; Kervio, E.; Morlock, G.; Heinz, D.W.; Jahn, D.; Retey, J.; Schubert, W.D.
Structural and functional comparison of HemN to other radical SAM enzymes
Biol. Chem.
386
971-980
2005
Bacillus subtilis, Cereibacter sphaeroides, Cupriavidus necator, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Layer, G.; Grage, K.; Teschner, T.; Schuenemann, V.; Breckau, D.; Masoumi, A.; Jahn, M.; Heathcote, P.; Trautwein, A.X.; Jahn, D.
Radical S-adenosylmethionine enzyme coproporphyrinogen III oxidase HemN: functional features of the [4Fe-4S] cluster and the two bound S-adenosyl-L-methionines
J. Biol. Chem.
280
29038-29046
2005
Escherichia coli
Manually annotated by BRENDA team
Layer, G.; Pierik, A.J.; Trost, M.; Rigby, S.E.; Leech, H.K.; Grage, K.; Breckau, D.; Astner, I.; Jaensch, L.; Heathcote, P.; Warren, M.J.; Heinz, D.W.; Jahn, D.
The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN
J. Biol. Chem.
281
15727-15734
2006
Escherichia coli
Manually annotated by BRENDA team
Yokoyama, K.; Ohmori, D.; Kudo, F.; Eguchi, T.
Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy
Biochemistry
47
8950-8960
2008
Niallia circulans
Manually annotated by BRENDA team
Frey, P.A.; Hegeman, A.D.; Ruzicka, F.J.
The radical SAM superfamily
Crit. Rev. Biochem. Mol. Biol.
43
63-88
2008
Homo sapiens
Manually annotated by BRENDA team
Yokoyama, K.; Numakura, M.; Kudo, F.; Ohmori, D.; Eguchi, T.
Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin
J. Am. Chem. Soc.
129
15147-15155
2007
Niallia circulans
Manually annotated by BRENDA team
Shaveta, G.; Shi, J.; Chow, V.T.; Song, J.
Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme
Biochem. Biophys. Res. Commun.
391
1390-1395
2010
Homo sapiens
Manually annotated by BRENDA team
Rand, K.; Noll, C.; Schiebel, H.M.; Kemken, D.; Duelcks, T.; Kalesse, M.; Heinz, D.W.; Layer, G.
The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX
Biol. Chem.
391
55-63
2010
Escherichia coli
Manually annotated by BRENDA team
Duschene, K.S.; Broderick, J.B.
The antiviral protein viperin is a radical SAM enzyme
FEBS Lett.
584
1263-1267
2010
Homo sapiens
Manually annotated by BRENDA team
Goto, T.; Aoki, R.; Minamizaki, K.; Fujita, Y.
Functional differentiation of two analogous coproporphyrinogen III oxidases for heme and chlorophyll biosynthesis pathways in the cyanobacterium Synechocystis sp. PCC 6803
Plant Cell Physiol.
51
650-663
2010
Synechocystis sp.
Manually annotated by BRENDA team
Abicht, H.K.; Martinez, J.; Layer, G.; Jahn, D.; Solioz, M.
Lactococcus lactis HemW (HemN) is a haem-binding protein with a putative role in haem trafficking
Biochem. J.
442
335-343
2012
Lactococcus lactis
Manually annotated by BRENDA team
Azzouzi, A.; Steunou, A.S.; Durand, A.; Khalfaoui-Hassani, B.; Bourbon, M.L.; Astier, C.; Bollivar, D.W.; Ouchane, S.
Coproporphyrin III excretion identifies the anaerobic coproporphyrinogen III oxidase HemN as a copper target in the Cu+-ATPase mutant copA- of Rubrivivax gelatinosus
Mol. Microbiol.
88
339-351
2013
Rubrivivax gelatinosus (I0HU37), Rubrivivax gelatinosus
Manually annotated by BRENDA team
Kim, E.J.; Oh, E.K.; Lee, J.K.
Role of HemF and HemN in the heme biosynthesis of Vibrio vulnificus under S-adenosylmethionine-limiting conditions
Mol. Microbiol.
96
497-512
2015
Vibrio vulnificus, Vibrio vulnificus ATCC 29307
Manually annotated by BRENDA team
Azzouzi, A.; Steunou, A.S.; Durand, A.; Khalfaoui-Hassani, B.; Bourbon, M.L.; Astier, C.; Bollivar, D.W.; Ouchane, S.
Coproporphyrin III excretion identifies the anaerobic coproporphyrinogen III oxidase HemN as a copper target in the Cu+-ATPase mutant copA- of Rubrivivax gelatinosus
Mol. Microbiol.
88
339-351
2013
Rubrivivax gelatinosus (I0HU37), Rubrivivax gelatinosus
Manually annotated by BRENDA team
Pratibha, P.; Singh, S.K.; Srinivasan, R.; Bhat, S.R.; Sreenivasulu, Y.
Gametophyte development needs mitochondrial coproporphyrinogen III oxidase function
Plant Physiol.
174
258-275
2017
Arabidopsis thaliana (Q9FMJ4), Arabidopsis thaliana
Manually annotated by BRENDA team
Ji, X.; Mo, T.; Liu, W.Q.; Ding, W.; Deng, Z.; Zhang, Q.
Revisiting the mechanism of the anaerobic coproporphyrinogen III oxidase HemN
Angew. Chem. Int. Ed. Engl.
58
6235-6238
2019
Escherichia coli
Manually annotated by BRENDA team
Choby, J.E.; Skaar, E.P.
Staphylococcus aureus Coproporphyrinogen III Oxidase is required for aerobic and anaerobic heme synthesis
mSphere
4
e00235-19
2019
Staphylococcus aureus
Manually annotated by BRENDA team