1.3.8.8: long-chain acyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about long-chain acyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

ACAD 9, AcdB, acyl-CoA dehydrogenase 9, BACH, CTE-II, EC 1.3.99.13, EC 1.3.99.3, LCAD, long chain acyl coenzyme A dehydrogenase, long chain acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, long-chain acyl-CoA hydrolase, long-chain acyl-coenzyme A dehydrogenase, MCAD, medium long-chain acyl-CoA dehydrogenase, More, MTE-II, palmitoyl-CoA dehydrogenase, palmitoyl-coenzyme A dehydrogenase, PtmO4, type-II acyl-CoA thioesterase, very long chain acyl-CoA dehydrogenase, very long-chain acyl-CoA dehydrogenase, very-long-chain acyl-CoA dehydrogenase, very-long-chain acyl-coenzyme A dehydrogenase, VLCAD, VLMCAD

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.8 With a flavin as acceptor

                1.3.8.8 long-chain acyl-CoA dehydrogenase

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Results	in table
5	Activating Compound
10993	AA Sequence
9	Application
1	CAS Registry Number
17	Cloned(Commentary)
11	Cofactor
3	Crystallization (Commentary)
1510	Disease/ Diagnostics
5	General Information
24	Inhibitors
54	KM Value [mM]
41	Localization
17	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
60	Organism
7	Pathway
3	pH Optimum
2	pH Stability
25	Protein Variants
25	Purification (Commentary)
1	Reaction
10	Reaction Type
60	Reference
76	Source Tissue
44	Specific Activity [micromol/min/mg]
2	Storage Stability
190	Substrates and Products (Substrate)
15	Subunits
83	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
6	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.3.8.8 - long-chain acyl-CoA dehydrogenase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

bezafibrate

2 entries

Clofibrate

Rattus norvegicus

-

activation, treated animals receiving 0.5% w/w neutralized acid for 2 weeks

391298

peroxisome proliferator

Rattus norvegicus

-

-

671275

-

Triton X-100

Rattus norvegicus

-

restores activity during ischemia

671584

bezafibrate

Homo sapiens

-

stimulates VLCAD gene expression to 44% in normal and to 150% in VLCAD-deficient fibroblasts, increases activity 2.2fold in normal fibroblasts, induces a dose-dependent increase in palmitate oxidation capacities in cells from patients with the myopathic form of VLCAD deficiency, complete normalization of cell fatty acid oxidation capacities after exposure to 500 mM for 48 h, but not in cells from severely affected patients

673935

bezafibrate

Homo sapiens

P49748

increased VLCAD residual enzyme activity in the presence of 0.4 mM bezafibrate

684281