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1.3.8.4: isovaleryl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about isovaleryl-CoA dehydrogenase, go to the full flat file.

Word Map on EC 1.3.8.4

Reaction

3-methylbutanoyl-CoA
+
electron-transfer flavoprotein
=
3-methylbut-2-enoyl-CoA
 +
reduced electron-transfer flavoprotein

Synonyms

acyl-CoA dehydrogenase, EC 1.3.99.10, i3VD, iso(3)valeryl-CoA dehydrogenase, isovaleric-CoA dehydrogenase, isovaleroyl-coenzyme A dehydrogenase, isovaleryl-coenzyme A dehydrogenase, IVD, IVDH, LiuA, Pden_3633, SBCAD, short/branched chain acyl-CoA dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.4 isovaleryl-CoA dehydrogenase

Inhibitors

Inhibitors on EC 1.3.8.4 - isovaleryl-CoA dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(methylenecyclopropyl)acetyl-CoA
2-aza-isovaleryl-CoA
-
substrate analogue
3-methylcrotonyl-CoA
-
-
Ag+
-
completely inhibits at 0.01 mM
alpha-keto-methylenecyclopropylpropionic acid
-
-
Cu2+
-
completely inhibits at 0.01 mM
D-glucose
0.15% D-glucose represses transcription
Hg2+
-
completely inhibits at 0.1 mM
hypoglycin
iodoacetamide
-
at 2 mM 19% activity remains
L-arginine
1% L-arginine represses transcription
L-glutamate
IVD transcription is strongly repressed by L-glutamate
Methylmercury iodide
N-ethylmaleimide
p-chloromercuribenzoate
-
at 0.1 mM 18% activity remains
p-hydroxymercuribenzoate
RYATLPNIMKAK
twelvemer peptide representing the electron transfer protein docking peptide, ETF betaArg191-betaLys202, competitively inhibits the enzyme reaction when electron transfer protein is used as the electron acceptor
sucrose
-
inhibits promoter activity
valproyl-CoA
competitive
valproyl-dephosphoCoA
competitive