1.3.7.5: phycocyanobilin:ferredoxin oxidoreductase
This is an abbreviated version!
For detailed information about phycocyanobilin:ferredoxin oxidoreductase, go to the full flat file.
Word Map on EC 1.3.7.5
-
1.3.7.5
-
bilins
-
cyanobacteria
-
ixalpha
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tetrapyrrole
-
chromophore
-
phytochrome
-
light-harvesting
-
synechocystis
-
phycobiliproteins
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ferredoxins
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vinyl
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four-electron
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d-ring
-
phycobilisomes
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phytochromobilin
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substrate-free
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phycoerythrobilin
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light-sensing
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biliproteins
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antenna
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holophytochrome
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two-electron
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nostoc
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apophytochrome
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cyanobacteriochromes
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photoreversible
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phycobilin
-
cyanophage
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fdbrs
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reddish
-
photoactive
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phycocyanin
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prochlorococcus
-
proton-donating
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myovirus
-
protein-substrate
-
hydronium
-
analysis
- 1.3.7.5
-
bilins
- cyanobacteria
- ixalpha
- tetrapyrrole
- chromophore
-
phytochrome
-
light-harvesting
- synechocystis
-
phycobiliproteins
- ferredoxins
-
vinyl
-
four-electron
-
d-ring
-
phycobilisomes
- phytochromobilin
-
substrate-free
- phycoerythrobilin
-
light-sensing
-
biliproteins
-
antenna
-
holophytochrome
-
two-electron
- nostoc
-
apophytochrome
-
cyanobacteriochromes
-
photoreversible
-
phycobilin
-
cyanophage
-
fdbrs
-
reddish
-
photoactive
- phycocyanin
- prochlorococcus
-
proton-donating
-
myovirus
-
protein-substrate
-
hydronium
- analysis
Reaction
+ 4 oxidized ferredoxin = + 4 reduced ferredoxin
Synonyms
3Z-phycocyanobilin:ferredoxin oxidoreductase, AmPcyAc, AmPcyAp, bilin reductase, FDBR, ferredoxin-dependent biliverdin reductase, ferredoxin:3Z-phycocyanobilin oxidoreductase, HY2 protein, oxidoreductase, ferredoxin:3Z-phycocyanobilin, Pcb:Fd oxidoreductase, PCB:ferredoxin oxidoreductase, PcyA, PCYA1, phycocyanobilin synthase, phycocyanobilin-ferredoxin oxidoreductase, phycocyanobilin:ferredoxin oxidoreductase, SyPcyA
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Reference
Reference on EC 1.3.7.5 - phycocyanobilin:ferredoxin oxidoreductase
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Frankenberg, N.; Mukougawa, K.; Kohchi, T.; Lagarias, J.C.
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms
Plant Cell
13
965-978
2001
Anabaena sp., Prochlorococcus sp., Synechococcus sp., Synechocystis sp. (Q55891), Nostoc punctiforme (Q93TM9), Prochlorococcus sp. CCMP1378 / MED4, Synechococcus sp. WH8102
Tooley, A.J.; Glazer, A.N.
Biosynthesis of the cyanobacterial light-harvesting polypeptide phycoerythrocyanin holo-a subunit in a heterologous host
J. Bacteriol.
184
4666-4671
2002
Anabaena sp.
Tooley, A.J.; Cai, Y.A.; Glazer, A.N.
Biosynthesis of a fluorescent cyanobacterial C-phycocyanin holo-a subunit in a heterologous host
Proc. Natl. Acad. Sci. USA
98
10560-10565
2001
Synechocystis sp.
Wu, S.H; McDowell, M.T.; Lagaris, J.C.
Phycocyanobilin is the natural precursor of the phytochrome chromophore in the green alga Mesotaenium caldariorum
J. Biol. Chem.
272
25700-25705
1997
Mesotaenium caldariorum
Tu, S.L.; Gunn, A.; Toney, M.D.; Britt, R.D.; Lagarias, J.C.
Biliverdin reduction by cyanobacterial phycocyanobilin:ferredoxin oxidoreductase (PcyA) proceeds via linear tetrapyrrole radical intermediates
J. Am. Chem. Soc.
126
8682-8693
2004
Anabaena sp.
Frankenberg, N.; Lagarias, J.C.
Phycocyanobilin:ferredoxin oxidoreductase of Anabaena sp. PCC 7120. Biochemical and spectroscopic
J. Biol. Chem.
278
9219-9226
2003
Anabaena sp.
Kami, C.; Mukougawa, K.; Muramoto, T.; Yokota, A.; Shinomura, T.; Lagarias, J.C.; Kohchi, T.
Complementation of phytochrome chromophore-deficient Arabidopsis by expression of phycocyanobilin:ferredoxin oxidoreductase
Proc. Natl. Acad. Sci. USA
101
1099-1104
2004
Synechocystis sp.
Mukougawa, K.; Kanamoto, H.; Kobayashi, T.; Yokota, A.; Kohchi, T.
Metabolic engineering to produce phytochromes with phytochromobilin, phycocyanobilin, or phycoerythrobilin chromophore in Escherichia coli
FEBS Lett.
580
1333-1338
2006
Synechococcus sp., Synechococcus sp. W8020
Hagiwara, Y.; Sugishima, M.; Takahashi, Y.; Fukuyama, K.
Induced-fitting and electrostatic potential change of PcyA upon substrate binding demonstrated by the crystal structure of the substrate-free form
FEBS Lett.
580
3823-3828
2006
Synechocystis sp.
Tu, S.L.; Sughrue, W.; Britt, R.D.; Lagarias, J.C.
A conserved histidine-aspartate pair is required for exovinyl reduction of biliverdin by a cyanobacterial phycocyanobilin:ferredoxin oxidoreductase
J. Biol. Chem.
281
3127-3136
2006
Nostoc sp., Nostoc sp. PCC 7120
Zhao, K.H.; Su, P.; Li, J.; Tu, J.M.; Zhou, M.; Bubenzer, C.; Scheer, H.
Chromophore attachment to phycobiliprotein beta-subunits: phycocyanobilin:cysteine-beta84 phycobiliprotein lyase activity of CpeS-like protein from Anabaena Sp. PCC7120
J. Biol. Chem.
281
8573-8581
2006
Anabaena sp., Anabaena sp. PCC 7120
Hagiwara, Y.; Sugishima, M.; Takahashi, Y.; Fukuyama, K.
Crystal structure of phycocyanobilin:ferredoxin oxidoreductase in complex with biliverdin IXalpha, a key enzyme in the biosynthesis of phycocyanobilin
Proc. Natl. Acad. Sci. USA
103
27-32
2006
Synechocystis sp. (Q55891), Synechocystis sp.
Tu, S.L.; Rockwell, N.C.; Lagarias, J.C.; Fisher, A.J.
Insight into the radical mechanism of phycocyanobilin-ferredoxin oxidoreductase (PcyA) revealed by X-ray crystallography and biochemical measurements
Biochemistry
46
1484-1494
2007
Nostoc sp. PCC 7120 = FACHB-418 (Q93TN0)
Zhang, W.; Guan, X.; Yang, Y.; Ge, B.; Chen, H.; Li, F.; Qin, S.
Biosynthesis of fluorescent allophycocyanin alpha-subunits by autocatalysis in Escherichia coli
Biotechnol. Appl. Biochem.
52
135-140
2009
Synechocystis sp. (Q55891)
Stoll, S.; Gunn, A.; Brynda, M.; Sughrue, W.; Kohler, A.C.; Ozarowski, A.; Fisher, A.J.; Lagarias, J.C.; Britt, R.D.
Structure of the biliverdin radical intermediate in phycocyanobilin:ferredoxin oxidoreductase identified by high-field EPR and DFT
J. Am. Chem. Soc.
131
1986-1995
2009
Synechocystis sp. (Q55891), Synechocystis sp., Nostoc sp. PCC 7120 = FACHB-418 (Q93TN0)
Wada, K.; Hagiwara, Y.; Yutani, Y.; Fukuyama, K.
One residue substitution in PcyA leads to unexpected changes in tetrapyrrole substrate binding
Biochem. Biophys. Res. Commun.
402
373-377
2010
Synechocystis sp. (Q55891)
Okada, K.
HO1 and PcyA proteins involved in phycobilin biosynthesis form a 1:2 complex with ferredoxin-1 required for photosynthesis
FEBS Lett.
583
1251-1256
2009
Thermosynechococcus vestitus
Hagiwara, Y.; Sugishima, M.; Khawn, H.; Kinoshita, H.; Inomata, K.; Shang, L.; Lagarias, J.C.; Takahashi, Y.; Fukuyama, K.
Structural insights into vinyl reduction regiospecificity of phycocyanobilin:ferredoxin oxidoreductase (PcyA)
J. Biol. Chem.
285
1000-1007
2010
Synechocystis sp. (Q55891), Synechocystis sp.
Kabasakal, B.; Gae, D.D.; Li, J.; Clark Lagarias, J.; Koehl, P.; Fisher, A.J.
His74 conservation in the bilin reductase PcyA family reflects an important role in protein-substrate structure and dynamics
Arch. Biochem. Biophys.
537
233-242
2013
Synechocystis sp.
Shang, L.; Rockwell, N.C.; Martin, S.S.; Lagarias, J.C.
Biliverdin amides reveal roles for propionate side chains in bilin reductase recognition and in holophytochrome assembly and photoconversion
Biochemistry
49
6070-6082
2010
Anabaena sp., Anabaena sp. PCC 7120
Kohler, A.C.; Gae, D.D.; Richley, M.A.; Stoll, S.; Gunn, A.; Lim, S.; Martin, S.S.; Doukov, T.I.; Britt, R.D.; Ames, J.B.; Lagarias, J.C.; Fisher, A.J.
Structural basis for hydration dynamics in radical stabilization of bilin reductase mutants
Biochemistry
49
6206-6218
2010
Synechocystis sp.
Alvey, R.M.; Biswas, A.; Schluchter, W.M.; Bryant, D.A.
Attachment of noncognate chromophores to CpcA of Synechocystis sp. PCC 6803 and Synechococcus sp. PCC 7002 by heterologous expression in Escherichia coli
Biochemistry
50
4890-4902
2011
Synechococcus sp., Synechococcus sp. 7002
Alvey, R.M.; Biswas, A.; Schluchter, W.M.; Bryant, D.A.
Effects of modified phycobilin biosynthesis in the cyanobacterium Synechococcus sp. strain PCC 7002
J. Bacteriol.
193
1663-1671
2011
Synechococcus sp.
Ceron-Carrasco, J.; Jacquemin, D.; Laurent, A.
First computational step towards the understanding of the antioxidant activity of the phycocyanobilin ferredoxin oxidoreductase in complex with biliverdin IXalpha
Comput. Theoret. Chem.
1077
58-64
2016
Synechocystis sp. PCC 6803 (Q55891)
-
Hagiwara, Y.; Wada, K.; Irikawa, T.; Sato, H.; Unno, M.; Yamamoto, K.; Fukuyama, K.; Sugishima, M.
Atomic-resolution structure of the phycocyanobilin ferredoxin oxidoreductase I86D mutant in complex with fully protonated biliverdin
FEBS Lett.
590
3425-3434
2016
Synechocystis sp. PCC 6803 (Q55891)
Iijima, E.; Gleeson, M.; Unno, M.; Mori, S.
QM/MM investigation for protonation states in a bilin reductase PcyA-biliverdin IXalpha complex
ChemPhysChem
19
1809-1813
2018
Synechocystis sp. PCC 6803 (Q55891)
Miyake, K.; Fushimi, K.; Kashimoto, T.; Maeda, K.; Ni-Ni-Win, K.; Kimura, H.; Sugishima, M.; Ikeuchi, M.; Narikawa, R.
Functional diversification of two bilin reductases for light perception and harvesting in unique cyanobacterium Acaryochloris marina MBIC 11017
FEBS J.
287
4016-4031
2020
Acaryochloris marina (A8ZMS5), Acaryochloris marina (B0CAR8), Acaryochloris marina, Synechocystis sp. PCC 6803 (Q55891), Acaryochloris marina MBIC 11017 (A8ZMS5), Acaryochloris marina MBIC 11017 (B0CAR8)
Zhang, W.; Zhong, H.; Lu, H.; Zhang, Y.; Deng, X.; Huang, K.; Duanmu, D.
Characterization of ferredoxin-dependent biliverdin reductase PCYA1 reveals the dual function in retrograde bilin biosynthesis and interaction with light-dependent protochlorophyllide oxidoreductase LPOR in Chlamydomonas reinhardtii
Front. Plant Sci.
9
676
2018
Chlamydomonas reinhardtii (A8HUP3), Chlamydomonas reinhardtii, Chlamydomonas reinhardtii 4A+ (A8HUP3)
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