1.3.5.3: protoporphyrinogen IX dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about protoporphyrinogen IX dehydrogenase (quinone), go to the full flat file.

Reaction

Synonyms

HemG, HemG protein, PPO, PPOX, PPX, PPX1, protogen oxidase, protoporphyrinogen IX dehydrogenase (menaquinone), protoporphyrinogen IX oxidase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.5 With a quinone or related compound as acceptor

                1.3.5.3 protoporphyrinogen IX dehydrogenase (quinone)

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Results	in table
3088	AA Sequence
2	Cloned(Commentary)
3	Cofactor
2	General Information
1	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
2	Localization
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
3	Organism
8	Pathway
1	pH Optimum
2	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reference
1	Specific Activity [micromol/min/mg]
9	Substrates and Products (Substrate)
4	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.3.5.3 - protoporphyrinogen IX dehydrogenase (quinone)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

protoporphyrinogen IX + 3 menadione

protoporphyrin IX + 3 menadiol

2 entries

protoporphyrinogen IX + 3 menaquinone

protoporphyrin IX + 3 menaquinol

2 entries

protoporphyrinogen IX + 3 plastoquinone

protoporphyrin IX + 3 plastoquinol

Chlamydomonas reinhardtii

-

-

764518

-

-

?

protoporphyrinogen IX + 3 triphenyltetrazolium chloride

protoporphyrin IX + ?

Escherichia coli

-

artificial electron acceptor

726366

-

-

?

protoporphyrinogen IX + 3 ubiquinone

protoporphyrin IX + 3 ubiquinol

2 entries

additional information

?

-

Escherichia coli

-

potential electron acceptors, i.e. 2, 6-dichloroindophenol, phenazine methosulfate, menadione, and vitamin K1, respectively, directly oxidize the substrate in the absence of HemG

726366

-

-

?

protoporphyrinogen IX + 3 menadione

protoporphyrin IX + 3 menadiol

Escherichia coli

-

the enzyme enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments

696347

-

-

?

protoporphyrinogen IX + 3 menadione

protoporphyrin IX + 3 menadiol

Escherichia coli

-

HemG is specific for protoporphyrinogen. Neither mesoporphyrinogen nor coproporphyrinogen is oxidized by HemG

696347

-

-

?

protoporphyrinogen IX + 3 menaquinone

protoporphyrin IX + 3 menaquinol

Escherichia coli

-

-

726366

-

-

?

protoporphyrinogen IX + 3 menaquinone

protoporphyrin IX + 3 menaquinol

Escherichia coli

-

under anaerobic conditions

726366

-

-

?

protoporphyrinogen IX + 3 ubiquinone

protoporphyrin IX + 3 ubiquinol

Escherichia coli

-

-

726366

-

-

?

protoporphyrinogen IX + 3 ubiquinone

protoporphyrin IX + 3 ubiquinol

Escherichia coli

-

under aerobic conditions

726366

-

-

?