1.3.5.2: dihydroorotate dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.
Word Map on EC 1.3.5.2
-
1.3.5.2
-
pyrimidine
-
falciparum
-
plasmodium
-
leflunomide
-
brequinar
-
uridine
-
malaria
-
arthritis
-
antimalarial
-
rheumatoid
-
dihydroorotase
-
salvage
-
teriflunomide
-
dhods
-
autoimmune
-
orotidine
-
ump
-
atovaquone
-
triazolopyrimidine
-
flavoenzyme
-
medicine
-
phosphoribosyltransferase
-
antirheumatic
-
coq
-
drug development
-
decylubiquinone
-
dmards
-
synthesis
-
species-selective
-
pyre
-
pharmacology
-
isoxazole
-
transcarbamoylase
-
5-fluoroorotate
- 1.3.5.2
- pyrimidine
- falciparum
- plasmodium
- leflunomide
- brequinar
- uridine
- malaria
- arthritis
-
antimalarial
-
rheumatoid
- dihydroorotase
-
salvage
- teriflunomide
-
dhods
- autoimmune
- orotidine
- ump
- atovaquone
- triazolopyrimidine
-
flavoenzyme
- medicine
-
phosphoribosyltransferase
-
antirheumatic
- coq
- drug development
- decylubiquinone
-
dmards
- synthesis
-
species-selective
-
pyre
- pharmacology
-
isoxazole
-
transcarbamoylase
- 5-fluoroorotate
Reaction
Synonyms
class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, dihydroorotate dehydrogenase, EC 1.3.99.11, ETH_00004975, hDHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH
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Reference
Reference on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)
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Rowland, P.; Norager, S.; Jensen, K.F.; Larsen, S.
Crystallization and preliminary x-ray studies of membrane-associated Escherichia coli dihydroorotate dehydrogenase
Acta Crystallogr. Sect. D
56
659-661
2000
Escherichia coli
Bjoernberg, O.; Gruener, A.C.; Roepstorff, P.; Jensen, K.F.
The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis
Biochemistry
38
2899-2908
1999
Escherichia coli, Lactococcus lactis
Palfey, B.A.; Bjoernberg, O.; Jensen, K.F.
Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies
Biochemistry
40
4381-4390
2001
Escherichia coli
Liu, S.; Neidhardt, E.A.; Grossman, T.H.; Ocain, T.; Clardy, J.
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents
Structure
8
25-33
2000
Homo sapiens
Davis, J.P.; Copeland, R.A.
Histidine to alanine mutants of human dihydroorotate dehydrogenase. Identification of a brequinar-resistant mutant enzyme
Biochem. Pharmacol.
54
459-465
1997
Homo sapiens
Copeland, R.A.; Davis, J.P.; Dowling, R.L.; Lombardo, D.; Murphy, K.B.; Patterson, T.A.
Recombinant human dihydroorotate dehydrogenase: expression, purification, and characterization of a catalytically functional truncated enzyme
Arch. Biochem. Biophys.
323
79-86
1995
Homo sapiens
Bruneau, J.M.; Yea, C.M.; Spinella-Jaegle, S.; Fudali, C.; Woodward, K.; Robson, P.A.; Sautes, C.; Westwood, R.; Kuo, E.A.; Williamson, R.A.; Ruuth, E.
Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
Biochem. J.
336
299-303
1998
Homo sapiens
-
Ullrich, A.; Knecht, W.; Fries, M.; Loffler, M.
Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects?
Eur. J. Biochem.
268
1861-1868
2001
Homo sapiens, Mus musculus, Rattus norvegicus
Loeffler, M.; Becker, C.; Wegerle, E.; Schuster, G.
Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria
Histochem. Cell Biol.
105
119-128
1996
Bos taurus, Cavia porcellus, Homo sapiens, Mus musculus, Sus scrofa, Rattus norvegicus (Q63707)
Bader, B.; Knecht, W.; Fries, M.; Loffler, M.
Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase
Protein Expr. Purif.
13
414-422
1998
Homo sapiens, Rattus norvegicus
Krungkrai, J.
Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite
Biochim. Biophys. Acta
1243
351-360
1995
Plasmodium falciparum
Marcinkeviciene, J.; Jiang, W.; Locke, G.; Kopcho, L.M.; Rogers, M.J.; Copeland, R.A.
A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism
Arch. Biochem. Biophys.
377
178-186
2000
Enterococcus faecalis
Forman, H.J.; Kennedy, J.
Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme
Arch. Biochem. Biophys.
191
23-31
1978
Rattus norvegicus
Miller, R.W.
Dihydroorotate dehydrogenase (Neurospora)
Methods Enzymol.
51
63-69
1978
Neurospora crassa
Hines, V.; Keys, L.D.; Johnston, M.
Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase [published erratum appears in J Biol Chem 1987 Nov 5;262(31):15322]
J. Biol. Chem.
261
11386-11392
1986
Bos taurus
Hines, V.; Johnston, M.
Analysis of the kinetic mechanism of the bovine liver mitochondrial dihydroorotate dehydrogenase
Biochemistry
28
1222-1226
1989
Bos taurus
Karibian, D.
Dihydroorotate dehydrogenase (Escherichia coli)
Methods Enzymol.
51
58-63
1978
Escherichia coli
Miersch, J.; Krauss, G.J.; Metzger, U.
Properties and subcellular localization of dihydroorotate dehydrogenase in cells of tomato suspension culture
J. Plant Physiol.
122
55-66
1986
Solanum lycopersicum
-
Knecht, W.; Bergjohann, U.; Gonski, S.; Kirschbaum, B.; Loffler, M.
Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme
Eur. J. Biochem.
240
292-301
1996
Homo sapiens
Knecht, w.; Altekruse, D.; Rotgeri, A.; Gonski, S.; Loffler, M.
Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells
Protein Expr. Purif.
10
89-99
1997
Rattus norvegicus (Q63707)
Davis, J.P.; Cain, G.A.; Pitts, W.J.; Magolda, R.L.; Copeland, R.A.
The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase
Biochemistry
35
1270-1273
1996
Homo sapiens
Knecht, W.; Henseling, J.; Loffler, M.
Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid
Chem. Biol. Interact.
124
61-76
2000
Homo sapiens, Rattus norvegicus
McLean, J.E.; Neidhardt, E.A.; Grossman, T.H.; Hedstrom, L.
Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase
Biochemistry
40
2194-2200
2001
Homo sapiens
Leban, J.; Saeb, W.; Garcia, G.; Baumgartner, R.; Kramer, B.
Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement
Bioorg. Med. Chem. Lett.
14
55-58
2004
Homo sapiens
Ullrich, A.; Knecht, W.; Piskur, J.; Loffler, M.
Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes
FEBS Lett.
529
346-350
2002
Arabidopsis thaliana (P32746), Arabidopsis thaliana
Loffler, M.; Knecht, W.; Rawls, J.; Ullrich, A.; Dietz, C.
Drosophila melanogaster dihydroorotate dehydrogenase: the N-terminus is important for biological function in vivo but not for catalytic properties in vitro
Insect Biochem. Mol. Biol.
32
1159-1169
2002
Drosophila melanogaster
Shi, J.; Palfey, B.A.; Dertouzos, J.; Jensen, K.F.; Gafni, A.; Steel, D.
Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics
J. Am. Chem. Soc.
126
6914-6922
2004
Escherichia coli
Baldwin, J.; Farajallah, A.M.; Malmquist, N.A.; Rathod, P.K.; Phillips, M.A.
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity
J. Biol. Chem.
277
41827-41834
2002
Homo sapiens, Plasmodium falciparum (Q08210), Plasmodium falciparum
Baldwin, J.; Michnoff, C.H.; Malmquist, N.A.; White, J.; Roth, M.G.; Rathod, P.K.; Phillips, M.A.
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
J. Biol. Chem.
280
21847-21853
2005
Plasmodium falciparum
Takashima, E.; Inaoka, D.K.; Osanai, A.; Nara, T.; Odaka, M.; Aoki, T.; Inaka, K.; Harada, S.; Kita, K.
Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi
Mol. Biochem. Parasitol.
122
189-200
2002
Trypanosoma cruzi
Hansen, M.; Le Nours, J.; Johansson, E.; Antal, T.; Ullrich, A.; Loffler, M.; Larsen, S.
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain
Protein Sci.
13
1031-1042
2004
Rattus norvegicus
Fagan, R.L.; Nelson, M.N.; Pagano, P.M.; Palfey, B.A.
Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases
Biochemistry
45
14926-14932
2006
Escherichia coli, Homo sapiens
Zameitat, E.; Gojkovic, Z.; Knecht, W.; Piskur, J.; Loeffler, M.
Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans
FEBS J.
273
3183-3191
2006
Candida albicans (Q874I4), Candida albicans
Baumgartner, R.; Walloschek, M.; Kralik, M.; Gotschlich, A.; Tasler, S.; Mies, J.; Leban, J.
Dual binding mode of a novel series of DHODH inhibitors
J. Med. Chem.
49
1239-1247
2006
Homo sapiens (Q02127), Homo sapiens
Heikkilä, T.; Ramsey, C.; Davies, M.; Galtier, C.; Stead, A.M.W.; Johnson, A.P.; Fishwick, C.W.G.; Boa, A.N.; McConkey, G.A.
Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase
J. Med. Chem.
50
186-191
2007
Homo sapiens, Plasmodium falciparum (Q08210), Plasmodium falciparum
Small, Y.A.; Guallar, V.; Soudackov, A.V.; Hammes-Schiffer, S.
Hydrogen bonding pathways in human dihydroorotate dehydrogenase
J. Phys. Chem. B
110
19704-19710
2006
Homo sapiens (Q02127), Homo sapiens
Zameitat, E.; Freymark, G.; Dietz, C.D.; Loeffler, M.; Boelker, M.
Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of Ustilago maydis allows target validation of DHODH inhibitors in vivo
Appl. Environ. Microbiol.
73
3371-3379
2007
Homo sapiens (Q02127), Homo sapiens
Malmquist, N.A.; Gujjar, R.; Rathod, P.K.; Phillips, M.A.
Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase
Biochemistry
47
2466-2475
2008
Plasmodium falciparum (Q08210), Plasmodium falciparum
Walse, B.; Dufe, V.; Svensson, B.; Fritzson, I.; Dahlberg, L.; Khairoullina, A.; Wellmar, U.; Al-Karadaghi, S.
The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
Biochemistry
47
8929-8936
2008
Homo sapiens (Q02127), Homo sapiens
Fagan, R.L.; Palfey, B.A.
Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli
Biochemistry
48
7169-7178
2009
Escherichia coli (P0A7E1), Escherichia coli
Kow, R.L.; Whicher, J.R.; McDonald, C.A.; Palfey, B.A.; Fagan, R.L.
Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli
Biochemistry
48
9801-9809
2009
Escherichia coli
Deguchi, M.; Kishino, J.; Hattori, M.; Furue, Y.; Yamamoto, M.; Mochizuki, I.; Iguchi, M.; Hirano, Y.; Hojou, K.; Nagira, M.; Nishitani, Y.; Okazaki, K.; Yasui, K.; Arimura, A.
Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678
Eur. J. Pharmacol.
601
163-170
2008
Homo sapiens, Mus musculus
Patel, V.; Booker, M.; Kramer, M.; Ross, L.; Celatka, C.; Kennedy, L.; Dvorin, J.; Duraisingh, M.; Sliz, P.; Wirth, D.; Clardy, J.
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
J. Biol. Chem.
283
35078-35085
2008
Plasmodium berghei, Plasmodium vivax, Plasmodium falciparum (Q08210), Plasmodium falciparum
Deng, X.; Gujjar, R.; El Mazouni, F.; Kaminsky, W.; Malmquist, N.A.; Goldsmith, E.J.; Rathod, P.K.; Phillips, M.A.
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
J. Biol. Chem.
284
26999-27009
2009
Plasmodium falciparum (Q08210), Plasmodium falciparum
Davies, M.; Heikkila, T.; McConkey, G.; Fishwick, C.; Parsons, M.; Johnson, A.
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J. Med. Chem.
52
2683-2693
2009
Homo sapiens (Q02127), Homo sapiens, Plasmodium falciparum (Q08210), Plasmodium falciparum
Baumann, P.; Mandl-Weber, S.; Völkl, A.; Adam, C.; Bumeder, I.; Oduncu, F.; Schmidmaier, R.
Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells
Mol. Cancer Ther.
8
366-375
2009
Homo sapiens
Ojha, P.K.; Roy, K.
Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials
Eur. J. Med. Chem.
45
4645-4656
2010
Plasmodium falciparum (Q08210)
Hail, N.; Chen, P.; Kepa, J.J.; Bushman, L.R.; Shearn, C.
Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis
Free Radic. Biol. Med.
49
109-116
2010
Homo sapiens
Phillips, M.A.; Rathod, P.K.
Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy
Infect. Disord. Drug Targets
10
226-239
2010
Homo sapiens, Plasmodium falciparum (Q08210), Plasmodium falciparum
Booker, M.L.; Bastos, C.M.; Kramer, M.L.; Barker, R.H.; Skerlj, R.; Sidhu, A.B.; Deng, X.; Celatka, C.; Cortese, J.F.; Guerrero Bravo, J.E.; Crespo Llado, K.N.; Serrano, A.E.; Angulo-Barturen, I.; Jimenez-Diaz, M.B.; Viera, S.; Garuti, H.; Wittlin, S.; Papastogiannidis, P.; Lin, J.W.; Janse, C.J.; Khan, S.M.
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model
J. Biol. Chem.
285
33054-33064
2010
Plasmodium berghei, Plasmodium vivax, Plasmodium falciparum (Q08210), Plasmodium falciparum
Gujjar, R.; Marwaha, A.; El Mazouni, F.; White, J.; White, K.L.; Creason, S.; Shackleford, D.M.; Baldwin, J.; Charman, W.N.; Buckner, F.S.; Charman, S.; Rathod, P.K.; Phillips, M.A.
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice
J. Med. Chem.
52
1864-1872
2009
Plasmodium falciparum
Schaefer, C.h.M.; Schaefer, M.K.; Loefflerr, M.
Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons
Nucleosides Nucleotides Nucleic Acids
29
476-481
2010
Rattus norvegicus
Couto, S.G.; Cristina Nonato, M.; Costa-Filho, A.J.
Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension
Biochem. Biophys. Res. Commun.
414
487-492
2011
Escherichia coli (B1X8P9), Escherichia coli
Bedingfield, P.T.; Cowen, D.; Acklam, P.; Cunningham, F.; Parsons, M.R.; McConkey, G.A.; Fishwick, C.W.; Johnson, A.P.
Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases
J. Med. Chem.
55
5841-5850
2012
Plasmodium falciparum, Homo sapiens (Q02127), Homo sapiens
Hortua Triana, M.A.; Huynh, M.H.; Garavito, M.F.; Fox, B.A.; Bzik, D.J.; Carruthers, V.B.; Loeffler, M.; Zimmermann, B.H.
Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii
Mol. Biochem. Parasitol.
184
71-81
2012
Toxoplasma gondii
Hegewald, J.; Gross, U.; Bohne, W.
Identification of dihydroorotate dehydrogenase as a relevant drug target for 1-hydroxyquinolones in Toxoplasma gondii
Mol. Biochem. Parasitol.
190
6-15
2013
Toxoplasma gondii
Hey-Mogensen, M.; Goncalves, R.L.; Orr, A.L.; Brand, M.D.
Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria
Free Radic. Biol. Med.
72
149-155
2014
Rattus norvegicus
Zhu, J.; Han, L.; Diao, Y.; Ren, X.; Xu, M.; Xu, L.; Li, S.; Li, Q.; Dong, D.; Huang, J.; Liu, X.; Zhao, Z.; Wang, R.; Zhu, L.; Xu, Y.; Qian, X.; Li, H.
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase
J. Med. Chem.
58
1123-1139
2015
Homo sapiens (Q02172), Homo sapiens
Munier-Lehmann, H.; Lucas-Hourani, M.; Guillou, S.; Helynck, O.; Zanghi, G.; Noel, A.; Tangy, F.; Vidalain, P.O.; Janin, Y.L.
Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)
J. Med. Chem.
58
860-877
2015
Homo sapiens (Q02172), Homo sapiens
Stocks, P.A.; Barton, V.; Antoine, T.; Biagini, G.A.; Ward, S.A.; ONeill, P.M.
Novel inhibitors of the Plasmodium falciparum electron transport chain
Parasitology
141
50-65
2014
Plasmodium falciparum
Nonato, M.C.; de Padua, R.A.P.; David, J.S.; Reis, R.A.G.; Tomaleri, G.P.; DMuniz Pereira, H.; Calil, F.A.
Structural basis for the design of selective inhibitors for Schistosoma mansoni dihydroorotate dehydrogenase
Biochimie
158
180-190
2019
Schistosoma mansoni (G4VFD7), Schistosoma mansoni, Homo sapiens (Q02127), Homo sapiens
Petrovic, M.; Roschger, C.; Chaudary, S.; Zierer, A.; Mladenovic, M.; Jakovljevic, K.; Markovic, V.; Botta, B.; Joksovic, M.
Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes synthesis, cytotoxicity, lipophilicity and molecular docking studies
Bioorg. Chem.
105
104373
2020
Homo sapiens (Q02127), Homo sapiens
Calil, F.A.; David, J.S.; Chiappetta, E.R.C.; Fumagalli, F.; Mello, R.B.; Leite, F.H.A.; Castilho, M.S.; Emery, F.S.; Nonato, M.C.
Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase
Eur. J. Med. Chem.
167
357-366
2019
Schistosoma mansoni (G4VFD7), Schistosoma mansoni, Homo sapiens (Q02127), Homo sapiens
Garavito, M.F.; Narvaez-Ortiz, H.Y.; Pulido, D.C.; Loeffler, M.; Judelson, H.S.; Restrepo, S.; Zimmermann, B.H.
Phytophthora infestans dihydroorotate dehydrogenase is a potential target for chemical control - a comparison with the enzyme from Solanum tuberosum
Front. Microbiol.
10
1479
2019
Phytophthora infestans (I7EMP0), Phytophthora infestans, Solanum tuberosum (M1BCR0), Solanum tuberosum
Matsubayashi, M.; Inaoka, D.; Komatsuya, K.; Hatta, T.; Kawahara, F.; Sakamoto, K.; Hikosaka, K.; Yamagishi, J.; Sasai, K.; Shiba, T.; Harada, S.; Tsuji, N.; Kita, K.
Novel characteristics of mitochondrial electron transport chain from Eimeria tenella
Genes (Basel)
10
29
2019
Eimeria tenella (U6KL66), Eimeria tenella
Hartuti, E.D.; Sakura, T.; Tagod, M.S.O.; Yoshida, E.; Wang, X.; Mochizuki, K.; Acharjee, R.; Matsuo, Y.; Tokumasu, F.; Mori, M.; Waluyo, D.; Shiomi, K.; Nozaki, T.; Hamano, S.; Shiba, T.; Kita, K.; Inaoka, D.K.
Identification of 3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives as novel selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
Int. J. Mol. Sci.
22
7236
2021
Plasmodium falciparum (Q08210), Plasmodium falciparum
Madak, J.; Cuthbertson, C.; Miyata, Y.; Tamura, S.; Petrunak, E.; Stuckey, J.; Han, Y.; He, M.; Sun, D.; Showalter, H.; Neamati, N.
Design, synthesis, and biological evaluation of 4-quinoline carboxylic acids as inhibitors of dihydroorotate dehydrogenase
J. Med. Chem.
61
5162-5186
2018
Homo sapiens (Q02127)
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