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1.3.5.2: dihydroorotate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.3.5.2

Reaction

(S)-dihydroorotate
+
a quinone
=
Orotate
+
a quinol

Synonyms

class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, dihydroorotate dehydrogenase, EC 1.3.99.11, ETH_00004975, hDHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.2 dihydroorotate dehydrogenase (quinone)

Reference

Reference on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rowland, P.; Norager, S.; Jensen, K.F.; Larsen, S.
Crystallization and preliminary x-ray studies of membrane-associated Escherichia coli dihydroorotate dehydrogenase
Acta Crystallogr. Sect. D
56
659-661
2000
Escherichia coli
Manually annotated by BRENDA team
Bjoernberg, O.; Gruener, A.C.; Roepstorff, P.; Jensen, K.F.
The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis
Biochemistry
38
2899-2908
1999
Escherichia coli, Lactococcus lactis
Manually annotated by BRENDA team
Palfey, B.A.; Bjoernberg, O.; Jensen, K.F.
Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies
Biochemistry
40
4381-4390
2001
Escherichia coli
Manually annotated by BRENDA team
Liu, S.; Neidhardt, E.A.; Grossman, T.H.; Ocain, T.; Clardy, J.
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents
Structure
8
25-33
2000
Homo sapiens
Manually annotated by BRENDA team
Davis, J.P.; Copeland, R.A.
Histidine to alanine mutants of human dihydroorotate dehydrogenase. Identification of a brequinar-resistant mutant enzyme
Biochem. Pharmacol.
54
459-465
1997
Homo sapiens
Manually annotated by BRENDA team
Copeland, R.A.; Davis, J.P.; Dowling, R.L.; Lombardo, D.; Murphy, K.B.; Patterson, T.A.
Recombinant human dihydroorotate dehydrogenase: expression, purification, and characterization of a catalytically functional truncated enzyme
Arch. Biochem. Biophys.
323
79-86
1995
Homo sapiens
Manually annotated by BRENDA team
Bruneau, J.M.; Yea, C.M.; Spinella-Jaegle, S.; Fudali, C.; Woodward, K.; Robson, P.A.; Sautes, C.; Westwood, R.; Kuo, E.A.; Williamson, R.A.; Ruuth, E.
Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
Biochem. J.
336
299-303
1998
Homo sapiens
-
Manually annotated by BRENDA team
Ullrich, A.; Knecht, W.; Fries, M.; Loffler, M.
Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects?
Eur. J. Biochem.
268
1861-1868
2001
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Loeffler, M.; Becker, C.; Wegerle, E.; Schuster, G.
Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria
Histochem. Cell Biol.
105
119-128
1996
Bos taurus, Cavia porcellus, Homo sapiens, Mus musculus, Sus scrofa, Rattus norvegicus (Q63707)
Manually annotated by BRENDA team
Bader, B.; Knecht, W.; Fries, M.; Loffler, M.
Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase
Protein Expr. Purif.
13
414-422
1998
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Krungkrai, J.
Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite
Biochim. Biophys. Acta
1243
351-360
1995
Plasmodium falciparum
Manually annotated by BRENDA team
Marcinkeviciene, J.; Jiang, W.; Locke, G.; Kopcho, L.M.; Rogers, M.J.; Copeland, R.A.
A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism
Arch. Biochem. Biophys.
377
178-186
2000
Enterococcus faecalis
Manually annotated by BRENDA team
Forman, H.J.; Kennedy, J.
Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme
Arch. Biochem. Biophys.
191
23-31
1978
Rattus norvegicus
Manually annotated by BRENDA team
Miller, R.W.
Dihydroorotate dehydrogenase (Neurospora)
Methods Enzymol.
51
63-69
1978
Neurospora crassa
Manually annotated by BRENDA team
Hines, V.; Keys, L.D.; Johnston, M.
Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase [published erratum appears in J Biol Chem 1987 Nov 5;262(31):15322]
J. Biol. Chem.
261
11386-11392
1986
Bos taurus
Manually annotated by BRENDA team
Hines, V.; Johnston, M.
Analysis of the kinetic mechanism of the bovine liver mitochondrial dihydroorotate dehydrogenase
Biochemistry
28
1222-1226
1989
Bos taurus
Manually annotated by BRENDA team
Karibian, D.
Dihydroorotate dehydrogenase (Escherichia coli)
Methods Enzymol.
51
58-63
1978
Escherichia coli
Manually annotated by BRENDA team
Miersch, J.; Krauss, G.J.; Metzger, U.
Properties and subcellular localization of dihydroorotate dehydrogenase in cells of tomato suspension culture
J. Plant Physiol.
122
55-66
1986
Solanum lycopersicum
-
Manually annotated by BRENDA team
Knecht, W.; Bergjohann, U.; Gonski, S.; Kirschbaum, B.; Loffler, M.
Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme
Eur. J. Biochem.
240
292-301
1996
Homo sapiens
Manually annotated by BRENDA team
Knecht, w.; Altekruse, D.; Rotgeri, A.; Gonski, S.; Loffler, M.
Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells
Protein Expr. Purif.
10
89-99
1997
Rattus norvegicus (Q63707)
Manually annotated by BRENDA team
Davis, J.P.; Cain, G.A.; Pitts, W.J.; Magolda, R.L.; Copeland, R.A.
The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase
Biochemistry
35
1270-1273
1996
Homo sapiens
Manually annotated by BRENDA team
Knecht, W.; Henseling, J.; Loffler, M.
Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid
Chem. Biol. Interact.
124
61-76
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
McLean, J.E.; Neidhardt, E.A.; Grossman, T.H.; Hedstrom, L.
Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase
Biochemistry
40
2194-2200
2001
Homo sapiens
Manually annotated by BRENDA team
Leban, J.; Saeb, W.; Garcia, G.; Baumgartner, R.; Kramer, B.
Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement
Bioorg. Med. Chem. Lett.
14
55-58
2004
Homo sapiens
Manually annotated by BRENDA team
Ullrich, A.; Knecht, W.; Piskur, J.; Loffler, M.
Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes
FEBS Lett.
529
346-350
2002
Arabidopsis thaliana (P32746), Arabidopsis thaliana
Manually annotated by BRENDA team
Loffler, M.; Knecht, W.; Rawls, J.; Ullrich, A.; Dietz, C.
Drosophila melanogaster dihydroorotate dehydrogenase: the N-terminus is important for biological function in vivo but not for catalytic properties in vitro
Insect Biochem. Mol. Biol.
32
1159-1169
2002
Drosophila melanogaster
Manually annotated by BRENDA team
Shi, J.; Palfey, B.A.; Dertouzos, J.; Jensen, K.F.; Gafni, A.; Steel, D.
Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics
J. Am. Chem. Soc.
126
6914-6922
2004
Escherichia coli
Manually annotated by BRENDA team
Baldwin, J.; Farajallah, A.M.; Malmquist, N.A.; Rathod, P.K.; Phillips, M.A.
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity
J. Biol. Chem.
277
41827-41834
2002
Homo sapiens, Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Baldwin, J.; Michnoff, C.H.; Malmquist, N.A.; White, J.; Roth, M.G.; Rathod, P.K.; Phillips, M.A.
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
J. Biol. Chem.
280
21847-21853
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Takashima, E.; Inaoka, D.K.; Osanai, A.; Nara, T.; Odaka, M.; Aoki, T.; Inaka, K.; Harada, S.; Kita, K.
Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi
Mol. Biochem. Parasitol.
122
189-200
2002
Trypanosoma cruzi
Manually annotated by BRENDA team
Hansen, M.; Le Nours, J.; Johansson, E.; Antal, T.; Ullrich, A.; Loffler, M.; Larsen, S.
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain
Protein Sci.
13
1031-1042
2004
Rattus norvegicus
Manually annotated by BRENDA team
Fagan, R.L.; Nelson, M.N.; Pagano, P.M.; Palfey, B.A.
Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases
Biochemistry
45
14926-14932
2006
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Zameitat, E.; Gojkovic, Z.; Knecht, W.; Piskur, J.; Loeffler, M.
Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans
FEBS J.
273
3183-3191
2006
Candida albicans (Q874I4), Candida albicans
Manually annotated by BRENDA team
Baumgartner, R.; Walloschek, M.; Kralik, M.; Gotschlich, A.; Tasler, S.; Mies, J.; Leban, J.
Dual binding mode of a novel series of DHODH inhibitors
J. Med. Chem.
49
1239-1247
2006
Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team
Heikkilä, T.; Ramsey, C.; Davies, M.; Galtier, C.; Stead, A.M.W.; Johnson, A.P.; Fishwick, C.W.G.; Boa, A.N.; McConkey, G.A.
Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase
J. Med. Chem.
50
186-191
2007
Homo sapiens, Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Small, Y.A.; Guallar, V.; Soudackov, A.V.; Hammes-Schiffer, S.
Hydrogen bonding pathways in human dihydroorotate dehydrogenase
J. Phys. Chem. B
110
19704-19710
2006
Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team
Zameitat, E.; Freymark, G.; Dietz, C.D.; Loeffler, M.; Boelker, M.
Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of Ustilago maydis allows target validation of DHODH inhibitors in vivo
Appl. Environ. Microbiol.
73
3371-3379
2007
Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team
Malmquist, N.A.; Gujjar, R.; Rathod, P.K.; Phillips, M.A.
Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase
Biochemistry
47
2466-2475
2008
Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Walse, B.; Dufe, V.; Svensson, B.; Fritzson, I.; Dahlberg, L.; Khairoullina, A.; Wellmar, U.; Al-Karadaghi, S.
The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
Biochemistry
47
8929-8936
2008
Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team
Fagan, R.L.; Palfey, B.A.
Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli
Biochemistry
48
7169-7178
2009
Escherichia coli (P0A7E1), Escherichia coli
Manually annotated by BRENDA team
Kow, R.L.; Whicher, J.R.; McDonald, C.A.; Palfey, B.A.; Fagan, R.L.
Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli
Biochemistry
48
9801-9809
2009
Escherichia coli
Manually annotated by BRENDA team
Deguchi, M.; Kishino, J.; Hattori, M.; Furue, Y.; Yamamoto, M.; Mochizuki, I.; Iguchi, M.; Hirano, Y.; Hojou, K.; Nagira, M.; Nishitani, Y.; Okazaki, K.; Yasui, K.; Arimura, A.
Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678
Eur. J. Pharmacol.
601
163-170
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Patel, V.; Booker, M.; Kramer, M.; Ross, L.; Celatka, C.; Kennedy, L.; Dvorin, J.; Duraisingh, M.; Sliz, P.; Wirth, D.; Clardy, J.
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
J. Biol. Chem.
283
35078-35085
2008
Plasmodium berghei, Plasmodium vivax, Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Deng, X.; Gujjar, R.; El Mazouni, F.; Kaminsky, W.; Malmquist, N.A.; Goldsmith, E.J.; Rathod, P.K.; Phillips, M.A.
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
J. Biol. Chem.
284
26999-27009
2009
Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Davies, M.; Heikkila, T.; McConkey, G.; Fishwick, C.; Parsons, M.; Johnson, A.
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J. Med. Chem.
52
2683-2693
2009
Homo sapiens (Q02127), Homo sapiens, Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Baumann, P.; Mandl-Weber, S.; Völkl, A.; Adam, C.; Bumeder, I.; Oduncu, F.; Schmidmaier, R.
Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells
Mol. Cancer Ther.
8
366-375
2009
Homo sapiens
Manually annotated by BRENDA team
Ojha, P.K.; Roy, K.
Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials
Eur. J. Med. Chem.
45
4645-4656
2010
Plasmodium falciparum (Q08210)
Manually annotated by BRENDA team
Hail, N.; Chen, P.; Kepa, J.J.; Bushman, L.R.; Shearn, C.
Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis
Free Radic. Biol. Med.
49
109-116
2010
Homo sapiens
Manually annotated by BRENDA team
Phillips, M.A.; Rathod, P.K.
Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy
Infect. Disord. Drug Targets
10
226-239
2010
Homo sapiens, Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Booker, M.L.; Bastos, C.M.; Kramer, M.L.; Barker, R.H.; Skerlj, R.; Sidhu, A.B.; Deng, X.; Celatka, C.; Cortese, J.F.; Guerrero Bravo, J.E.; Crespo Llado, K.N.; Serrano, A.E.; Angulo-Barturen, I.; Jimenez-Diaz, M.B.; Viera, S.; Garuti, H.; Wittlin, S.; Papastogiannidis, P.; Lin, J.W.; Janse, C.J.; Khan, S.M.
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model
J. Biol. Chem.
285
33054-33064
2010
Plasmodium berghei, Plasmodium vivax, Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Gujjar, R.; Marwaha, A.; El Mazouni, F.; White, J.; White, K.L.; Creason, S.; Shackleford, D.M.; Baldwin, J.; Charman, W.N.; Buckner, F.S.; Charman, S.; Rathod, P.K.; Phillips, M.A.
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice
J. Med. Chem.
52
1864-1872
2009
Plasmodium falciparum
Manually annotated by BRENDA team
Schaefer, C.h.M.; Schaefer, M.K.; Loefflerr, M.
Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons
Nucleosides Nucleotides Nucleic Acids
29
476-481
2010
Rattus norvegicus
Manually annotated by BRENDA team
Couto, S.G.; Cristina Nonato, M.; Costa-Filho, A.J.
Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension
Biochem. Biophys. Res. Commun.
414
487-492
2011
Escherichia coli (B1X8P9), Escherichia coli
Manually annotated by BRENDA team
Bedingfield, P.T.; Cowen, D.; Acklam, P.; Cunningham, F.; Parsons, M.R.; McConkey, G.A.; Fishwick, C.W.; Johnson, A.P.
Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases
J. Med. Chem.
55
5841-5850
2012
Plasmodium falciparum, Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team
Hortua Triana, M.A.; Huynh, M.H.; Garavito, M.F.; Fox, B.A.; Bzik, D.J.; Carruthers, V.B.; Loeffler, M.; Zimmermann, B.H.
Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii
Mol. Biochem. Parasitol.
184
71-81
2012
Toxoplasma gondii
Manually annotated by BRENDA team
Hegewald, J.; Gross, U.; Bohne, W.
Identification of dihydroorotate dehydrogenase as a relevant drug target for 1-hydroxyquinolones in Toxoplasma gondii
Mol. Biochem. Parasitol.
190
6-15
2013
Toxoplasma gondii
Manually annotated by BRENDA team
Hey-Mogensen, M.; Goncalves, R.L.; Orr, A.L.; Brand, M.D.
Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria
Free Radic. Biol. Med.
72
149-155
2014
Rattus norvegicus
Manually annotated by BRENDA team
Zhu, J.; Han, L.; Diao, Y.; Ren, X.; Xu, M.; Xu, L.; Li, S.; Li, Q.; Dong, D.; Huang, J.; Liu, X.; Zhao, Z.; Wang, R.; Zhu, L.; Xu, Y.; Qian, X.; Li, H.
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase
J. Med. Chem.
58
1123-1139
2015
Homo sapiens (Q02172), Homo sapiens
Manually annotated by BRENDA team
Munier-Lehmann, H.; Lucas-Hourani, M.; Guillou, S.; Helynck, O.; Zanghi, G.; Noel, A.; Tangy, F.; Vidalain, P.O.; Janin, Y.L.
Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)
J. Med. Chem.
58
860-877
2015
Homo sapiens (Q02172), Homo sapiens
Manually annotated by BRENDA team
Stocks, P.A.; Barton, V.; Antoine, T.; Biagini, G.A.; Ward, S.A.; ONeill, P.M.
Novel inhibitors of the Plasmodium falciparum electron transport chain
Parasitology
141
50-65
2014
Plasmodium falciparum
Manually annotated by BRENDA team
Nonato, M.C.; de Padua, R.A.P.; David, J.S.; Reis, R.A.G.; Tomaleri, G.P.; DMuniz Pereira, H.; Calil, F.A.
Structural basis for the design of selective inhibitors for Schistosoma mansoni dihydroorotate dehydrogenase
Biochimie
158
180-190
2019
Schistosoma mansoni (G4VFD7), Schistosoma mansoni, Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team
Petrovic, M.; Roschger, C.; Chaudary, S.; Zierer, A.; Mladenovic, M.; Jakovljevic, K.; Markovic, V.; Botta, B.; Joksovic, M.
Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes synthesis, cytotoxicity, lipophilicity and molecular docking studies
Bioorg. Chem.
105
104373
2020
Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team
Calil, F.A.; David, J.S.; Chiappetta, E.R.C.; Fumagalli, F.; Mello, R.B.; Leite, F.H.A.; Castilho, M.S.; Emery, F.S.; Nonato, M.C.
Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase
Eur. J. Med. Chem.
167
357-366
2019
Schistosoma mansoni (G4VFD7), Schistosoma mansoni, Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team
Garavito, M.F.; Narvaez-Ortiz, H.Y.; Pulido, D.C.; Loeffler, M.; Judelson, H.S.; Restrepo, S.; Zimmermann, B.H.
Phytophthora infestans dihydroorotate dehydrogenase is a potential target for chemical control - a comparison with the enzyme from Solanum tuberosum
Front. Microbiol.
10
1479
2019
Phytophthora infestans (I7EMP0), Phytophthora infestans, Solanum tuberosum (M1BCR0), Solanum tuberosum
Manually annotated by BRENDA team
Matsubayashi, M.; Inaoka, D.; Komatsuya, K.; Hatta, T.; Kawahara, F.; Sakamoto, K.; Hikosaka, K.; Yamagishi, J.; Sasai, K.; Shiba, T.; Harada, S.; Tsuji, N.; Kita, K.
Novel characteristics of mitochondrial electron transport chain from Eimeria tenella
Genes (Basel)
10
29
2019
Eimeria tenella (U6KL66), Eimeria tenella
Manually annotated by BRENDA team
Hartuti, E.D.; Sakura, T.; Tagod, M.S.O.; Yoshida, E.; Wang, X.; Mochizuki, K.; Acharjee, R.; Matsuo, Y.; Tokumasu, F.; Mori, M.; Waluyo, D.; Shiomi, K.; Nozaki, T.; Hamano, S.; Shiba, T.; Kita, K.; Inaoka, D.K.
Identification of 3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives as novel selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
Int. J. Mol. Sci.
22
7236
2021
Plasmodium falciparum (Q08210), Plasmodium falciparum
Manually annotated by BRENDA team
Madak, J.; Cuthbertson, C.; Miyata, Y.; Tamura, S.; Petrunak, E.; Stuckey, J.; Han, Y.; He, M.; Sun, D.; Showalter, H.; Neamati, N.
Design, synthesis, and biological evaluation of 4-quinoline carboxylic acids as inhibitors of dihydroorotate dehydrogenase
J. Med. Chem.
61
5162-5186
2018
Homo sapiens (Q02127)
Manually annotated by BRENDA team
Rodriguez, J.M.O.; Krupinska, E.; Wacklin-Knecht, H.; Knecht, W.
Preparation of human dihydroorotate dehydrogenase for interaction studies with lipid bilayers
Nucleosides Nucleotides Nucleic Acids
39
1306-1319
2020
Homo sapiens (Q02127), Homo sapiens
Manually annotated by BRENDA team