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1.3.5.1: succinate dehydrogenase

This is an abbreviated version!
For detailed information about succinate dehydrogenase, go to the full flat file.

Word Map on EC 1.3.5.1

Reaction

succinate
+
a quinone
=
fumarate
 +
a quinol

Synonyms

8-methylmenaquinol:fumarate reductase, AaSdhB, bacterial succinate:quinone oxidoreductase flavoprotein, complex II, Complex II homolog, complex II of the respiratory chain, complex II succinate:ubiquinone oxidoreductase, DCPIP oxidoreductase, dehydrogenase, succinate, dehydrogenase/complex II, EC 1.3.5.4, EC 1.3.99.1, Fcc3, fdrB, FL cyt, Flavocytochrome c3, FRD, FrdA, FRdABCD, FrdC, FRdCAB, FrdD, fumarate reductase, fumarate reductase complex, fumaric hydrogenase, Ifc3, Iron(III)-induced flavocytochrome C3, iron-sulfur subunit of succinate dehydrogenase, menaquinol-1 fumarate reductase, menaquinol-fumarate oxidoreductase, menaquinol:fumarate oxidoreductase, methylmenaquinol:fumarate reductase, MFR, MFR complex, MfrA, MfrB, mitochondrial complex II, mitochondrial succinate dehydrogenase, mitochondrial succinate:ubiquinone oxidoreductase, More, mQFR, MSMEG_0416, MSMEG_0417, MSMEG_0418, MSMEG_0419, MSMEG_0420, MSMEG_1669, MSMEG_1670, MSMEG_1671, MSMEG_1672, non-classical succinate:quinone reductase, QFR, quinol-fumarate reductase, quinol:fumarate reductase, SDG, SDG-1, SDG-2, SDH, SDH1, SDH2, SDH2-1, SDH2-2, SDH3, SDH4, SdhA, sdhABE, SDHB, SdhC, sdhCAB, SdhCDAB, SdhD, SDISP, SQR, succinate dehydrogenase, succinate dehydrogenase (caldariellaquinone), succinate dehydrogenase (quinone), succinate dehydrogenase B, succinate dehydrogenase complex, succinate dehydrogenase flavoprotein subunit Sdh1p, succinate dehydrogenase iron-sulfur protein, succinate dehydrogenase iron-sulphur protein, succinate dehydrogenase subunit B, succinate oxidoreductase, succinate-2,6-dichlorophenolindophenol oxidoreductase, succinate-coenzyme Q reductase, succinate-quinone oxidoreductase, succinate-quinone reductase, succinate-ubiquinone oxidoreductase, succinate:caldariellaquinone oxidoreductase, succinate:menaquinone 7-reductase, succinate:menaquinone oxidoreductase, succinate:menaquinone reductase, succinate:MK reductase, succinate:quinone oxidoreductase, succinate:quinone reductase, succinate:quinone reductases, succinate:ubiquinone oxidoreductase, succinate:ubiquinone reductase, succinic acid dehydrogenase, succinic dehydrogenase, succinodehydrogenase, succinyl dehydrogenase, Tneu_0423

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.1 succinate dehydrogenase

IC50 Value

IC50 Value on EC 1.3.5.1 - succinate dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00011 - 0.00233
(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)(3-phenoxyphenyl)methanone
0.00033 - 0.03
(4-chlorophenyl)(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
0.00063 - 0.03
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,2-diphenylethanone
0.00001 - 0.000051
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,6-dimethylhept-5-en-1-one
0.00013 - 0.000234
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-ethylhexan-1-one
0.0001 - 0.00258
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylbutan-1-one
0.00002 - 0.000122
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylhexan-1-one
0.000003 - 0.000004
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylundecan-1-one
0.00001 - 0.000299
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-phenylpropan-1-one
0.03
2,3-dimethoxy-5-(2-methylbutanoyl)pyridin-4(1H)-one
0.0128 - 0.0207
2,3-dimethoxy-5-(naphthalen-2-ylcarbonyl)pyridin-4(1H)-one
0.03
2,3-dimethoxy-5-[(2-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.00045 - 0.00298
2,3-dimethoxy-5-[(3-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.03
2,3-dimethoxy-5-[(4-methoxyphenyl)carbonyl]pyridin-4(1H)-one
0.00049 - 0.00408
2,3-dimethoxy-5-[(4-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.0006 - 0.00061
2-bromo-3-ethyl-1,4-naphthoquinone
0.000061 - 0.00109
2-bromo-3-methyl-1,4-naphthoquinone
0.00127 - 0.00194
2-bromo-3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridin-4(1H)-one
0.00001 - 0.000024
3-(4-tert-butylphenyl)-1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylpropan-1-one
0.00004
3-(difluoromethyl)-1-methyl-N-(1-[(3,5-dimethylphenyl)methyl]indol-7-yl)-1H-pyrazole-4-carboxamide
Sus scrofa
-
pH not specified in the publication, temperature not specified in the publication
0.03
3-[(4-chlorophenyl)carbonyl]-2,5,6-trimethoxypyridin-4(1H)-one
0.0138 - 0.0139
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxy-2-methylpyridin-4(1H)-one
0.03
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl diacetate
0.03
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl dimethanesulfonate
0.0008 - 0.00275
5-(biphenyl-4-ylcarbonyl)-2,3-dimethoxypyridin-4(1H)-one
0.03
5-[(2-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.00656 - 0.03
5-[(3-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.0034 - 0.0267
5-[(4-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.000004 - 0.0046
atpenin A5
0.0128
benodanil
Sus scrofa
-
pH 7.4,23°C
0.000245 - 0.0083
boscalid
0.0036 - 0.0043
carboxin
0.00013 - 0.00178
cyclohexyl(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
0.1233
fenfuram
Sus scrofa
-
pH 7.4,23°C
0.0289
flutolanil
Sus scrofa
-
pH 7.4,23°C
0.0273
furametpyr
Sus scrofa
-
pH 7.4,23°C
0.0304
mepronil
Sus scrofa
-
pH 7.4,23°C
0.0004
N-[2-(2,4-dichlorophenoxy)phenyl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
Sus scrofa
-
pH not specified in the publication, temperature not specified in the publication
0.000062
N-[2-(2-chloro-4-trifluoromethylphenoxy)phenyl]-3-(2-fluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
Sus scrofa
-
pH not specified in the publication, temperature not specified in the publication
0.0856
oxycarboxin
Sus scrofa
-
pH 7.4,23°C
0.00053 - 0.0013
penthiopyrad
0.0009 - 0.21
siccanin
0.00017
thifluzamide
Sus scrofa
-
pH 7.4,23°C