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1,16-hexadecadioyl-CoA + O2
?
-
-
-
-
?
16-hydroxy-palmitoyl-CoA + O2
?
-
-
-
-
?
2-oxoheptadecyldethio-CoA + O2
?
-
-
-
-
?
4,8,12-trimethyl-tridecanoyl-CoA + O2
?
-
-
-
-
?
4-methyl-nonanoyl-CoA + O2
?
-
-
-
-
?
6-phenyl-6-phenyl-hexanoyl-CoA + O2
?
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
acyl-CoA + O2
trans-2-enoyl-CoA + H2O2
-
assay at 25°C
-
-
ir
arachidoyl-CoA + O2
2-trans-eicosenoyl-CoA + H2O2
-
-
-
-
?
behenoyl-CoA + O2
2-trans-docosenoyl-CoA + H2O2
butyryl-CoA + O2
trans-2-butenoyl-CoA + H2O2
cis-3-decenoyl-CoA + O2
?
-
-
-
-
?
cis-3-hexenoyl-CoA + O2
?
-
best substrate for the isomerase activity of the enzyme
-
-
?
cis-3-octenoyl-CoA + O2
?
-
-
-
-
?
dec-4-cis-enoyl-CoA + O2
2-trans-4-cis-decadienoyl-CoA + H2O2
dec-4-trans-enoyl-CoA + O2
2-trans-4-trans-decadienoyl-CoA + H2O2
-
-
-
?
decanoyl-CoA + O2
trans-2,3-dehydrodecanoyl-CoA + H2O2
-
-
-
?
decanoyl-CoA + O2
trans-2-decenoyl-CoA + H2O2
dicarboxylic acid-CoAs with 6-16 carbon atoms + O2
?
-
-
-
-
?
dodecanoyl-CoA + O2
(2E)-dodec-2-enoyl-CoA + H2O2
dodecanoyl-CoA + O2
trans-dodec-2-enoyl-CoA + H2O2
-
-
-
-
r
eicosapentaenoyl-CoA + O2
?
-
-
-
-
?
furylpropionyl-CoA + O2
furylacryloyl-CoA + H2O2
-
also oxidizes aromatic/heterocyclic ring-substituted chromogenic substrates
-
?
hexadecanedioyl-CoA + O2
?
hexadecanoyl-CoA + O2
trans-2,3-dehydrohexadecanoyl-CoA + H2O2
-
-
-
?
hexanoyl-CoA + O2
(2E)-hex-2-enoyl-CoA + H2O2
indole-3-butyric acid-CoA + O2
?
-
-
-
-
?
jasmonic acid-CoA + O2
?
preferred substrate of ACX1
-
-
?
lauroyl-CoA + O2
trans-2-dodecenoyl-CoA + H2O2
leukodiacetyl-2,7-dichlorofluorescein + O2
?
-
-
-
-
?
linoleoyl-CoA + O2
2-trans-9-trans-12-trans-octadecatrienoyl-CoA + H2O2
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
nonanoyl-CoA + O2
trans-2-nonenoyl-CoA + H2O2
-
-
-
-
?
octadecanoyl-CoA + O2
?
preferred substrate of ACX2
-
-
?
octanoyl-CoA + O2
trans-2,3-dehydrooctanoyl-CoA + H2O2
-
-
-
?
octanoyl-CoA + O2
trans-2-octenoyl-CoA + H2O2
oleoyl-CoA + O2
2-trans-9-trans-octadecendienoyl-CoA + H2O2
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA + H2O2
pristanoyl-CoA + O2
trans-2,3-dehydropristanoyl-CoA + H2O2
-
-
-
?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
trans-3-decenoyl-CoA + O2
?
-
-
-
-
?
trans-3-hexenoyl-CoA + O2
?
-
-
-
-
?
trans-3-octenoyl-CoA + O2
?
-
-
-
-
?
trihydroxycholestanoyl-CoA + O2
trans-2,3-dehydrotrihydroxycholestanoyl-CoA + H2O2
-
-
-
?
trihydroxycoprostanoyl-CoA + O2
?
-
-
-
-
?
additional information
?
-
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
AtACX1 is medium-chain specific, AtACX2 is medium- to long-chain specific
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
AtACX3 is medium-chain-specific
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
AtACX3 is medium-chain-specific
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
AtACX1 is medium- to long-chain specific, AtSACXis strictly short-chain specific
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
AtACX1 is medium- to long-chain specific, AtSACXis strictly short-chain specific
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
ACOX-2 serves as specialized acyl-CoA oxidase that promotes the biosynthesis of short-chain omega-ascarosides
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
ACOX-3 serves as specialized acyl-CoA oxidase that promotes the biosynthesis of (omega-1)-ascarosides
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
ACOX-3 serves as specialized acyl-CoA oxidase that promotes the biosynthesis of (omega-1)-ascarosides
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
specificity: C4-C20 acyl-CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
significance in metabolism of alkanes of Candida tropicalis
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
the purified recombinant CrACX2 expressed in Escherichia coli catalyzes the oxidation of fatty acyl-CoAs into trans-2-enoyl-CoA and produces H2O2
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
enzyme acts selectively on fatty acyl-CoA with 16 or 18 carbon atoms, cis-9-unsaturated esters with a C16 or C18 acyl moiety being converted with higher rate than saturated or polyunsaturated fatty acyl-CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
Cucurbita sp.
-
preference for long-chain acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
Cucurbita sp.
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
highly specific for short-chain fatty acids
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
both isoforms ACX1.1 and 1.2 show similar broad substrate specificities
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
C8-C18 acyl CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
preference for C12-C18 acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
CoA derivatives of fatty acids with chain length from 8 to 18, first reaction of peroxisomal beta-oxidation, rate limiting for this process
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
key enzyme of beta-oxidation. A basal level of long chain ACX is always present along the barley life cycle, while a higher level of expression is typical of actively growing tissues such as germinating embryos, ovary before anthesis, developing embryos, shoots and root apexes. The enzyme plays a role not only during oil reserve mobilization, but also in plant growth and metabolism
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
preference for long-chain acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
C8-C18 acyl CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in lignin degradative system
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
3'-phosphate on the ribose ring and the structure of the adenine moiety are essential for substrate recognition, specificity is relatively low with respect to the structure of the pantric acid moiety
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
isoform ACO-I prefers short-chain acyl-CoA substrates, isoform ACO-II prefers long-chain acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
anti-elimination of pro-2R and pro-3R hydrogens of acyl-CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
chain-length specificity changes with acyl-CoA concentration used
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
most active towards C12-C18 acyl-CoA, C20 and C22 acyl-CoA also oxidized, C4 and C6 acyl-CoA hardly oxidized
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
C4-C18 monocarboxylic acid-CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
C6-C16 dicarboxylic-CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
CoA derivatives of fatty acids with chain length from 8 to 18, first reaction of peroxisomal beta-oxidation, rate limiting for this process
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
beta-oxidation of dicarboxylic acid-CoAs in rat liver is carried out exclusively in peroxisomes
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
C8-C18 acyl CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
long- and short-chain acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
long- and short-chain acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
anti-elimination of pro-2R and pro-3R hydrogens of acyl-CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
medium-chain-length specific
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
isoform SCOX prefers C4-C8 substrates, isoform MCOX prefers C10-C14 substrates
-
?
behenoyl-CoA + O2
2-trans-docosenoyl-CoA + H2O2
-
-
-
-
?
behenoyl-CoA + O2
2-trans-docosenoyl-CoA + H2O2
-
-
-
-
?
butyryl-CoA + O2
trans-2-butenoyl-CoA + H2O2
-
-
-
-
?
butyryl-CoA + O2
trans-2-butenoyl-CoA + H2O2
-
-
-
-
?
butyryl-CoA + O2
trans-2-butenoyl-CoA + H2O2
-
-
-
-
?
dec-4-cis-enoyl-CoA + O2
2-trans-4-cis-decadienoyl-CoA + H2O2
-
-
-
-
?
dec-4-cis-enoyl-CoA + O2
2-trans-4-cis-decadienoyl-CoA + H2O2
-
-
-
?
decanoyl-CoA + O2
trans-2-decenoyl-CoA + H2O2
-
-
-
-
?
decanoyl-CoA + O2
trans-2-decenoyl-CoA + H2O2
-
-
-
-
?
decanoyl-CoA + O2
trans-2-decenoyl-CoA + H2O2
-
-
-
-
?
decanoyl-CoA + O2
trans-2-decenoyl-CoA + H2O2
-
-
-
?
dodecanoyl-CoA + O2
(2E)-dodec-2-enoyl-CoA + H2O2
AtACX3 and AtACX1 show preference for
-
-
?
dodecanoyl-CoA + O2
(2E)-dodec-2-enoyl-CoA + H2O2
preferred substrate of ACX3
-
-
?
dodecanoyl-CoA + O2
(2E)-dodec-2-enoyl-CoA + H2O2
-
-
-
-
?
dodecanoyl-CoA + O2
(2E)-dodec-2-enoyl-CoA + H2O2
-
-
-
?
hexadecanedioyl-CoA + O2
?
-
-
-
-
?
hexadecanedioyl-CoA + O2
?
-
-
-
?
hexanoyl-CoA + O2
(2E)-hex-2-enoyl-CoA + H2O2
AtSACX shows preference for
-
-
?
hexanoyl-CoA + O2
(2E)-hex-2-enoyl-CoA + H2O2
-
-
-
-
?
hexanoyl-CoA + O2
(2E)-hex-2-enoyl-CoA + H2O2
-
-
-
-
?
hexanoyl-CoA + O2
(2E)-hex-2-enoyl-CoA + H2O2
-
recombinant enzyme
-
-
?
hexanoyl-CoA + O2
(2E)-hex-2-enoyl-CoA + H2O2
-
-
-
-
?
lauroyl-CoA + O2
trans-2-dodecenoyl-CoA + H2O2
-
-
-
-
?
lauroyl-CoA + O2
trans-2-dodecenoyl-CoA + H2O2
-
-
-
-
?
lauroyl-CoA + O2
trans-2-dodecenoyl-CoA + H2O2
-
low activity
-
-
?
lauroyl-CoA + O2
trans-2-dodecenoyl-CoA + H2O2
binding mode of C12-fatty acid suggests that the active site does not close upon substrate binding, but remains spacious during the entire catalytic process, the oxygen accessibility in the oxidative half-reaction thereby being maintained
-
-
?
lauroyl-CoA + O2
trans-2-dodecenoyl-CoA + H2O2
-
-
-
-
?
lauroyl-CoA + O2
trans-2-dodecenoyl-CoA + H2O2
-
-
-
-
?
lignoceroyl-CoA + O2
?
-
-
-
-
?
lignoceroyl-CoA + O2
?
-
-
-
-
?
lignoceroyl-CoA + O2
?
-
-
-
-
?
linoleoyl-CoA + O2
2-trans-9-trans-12-trans-octadecatrienoyl-CoA + H2O2
-
-
-
-
?
linoleoyl-CoA + O2
2-trans-9-trans-12-trans-octadecatrienoyl-CoA + H2O2
-
-
-
-
?
linoleoyl-CoA + O2
2-trans-9-trans-12-trans-octadecatrienoyl-CoA + H2O2
-
-
-
-
?
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
-
AtACX1
-
-
?
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
preferred substrate of ACX1
-
-
?
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
-
-
-
-
?
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
highest activity
-
-
ir
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
maximum activity
-
-
?
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
highest activity
-
-
ir
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
-
-
-
-
?
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
-
-
-
-
?
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
-
-
-
-
?
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
-
-
-
?
octanoyl-CoA + O2
trans-2-octenoyl-CoA + H2O2
-
-
-
-
?
octanoyl-CoA + O2
trans-2-octenoyl-CoA + H2O2
-
-
-
-
?
octanoyl-CoA + O2
trans-2-octenoyl-CoA + H2O2
-
-
-
-
?
octanoyl-CoA + O2
trans-2-octenoyl-CoA + H2O2
-
-
-
-
?
octanoyl-CoA + O2
trans-2-octenoyl-CoA + H2O2
-
-
-
-
?
oleoyl-CoA + O2
2-trans-9-trans-octadecendienoyl-CoA + H2O2
-
-
-
-
?
oleoyl-CoA + O2
2-trans-9-trans-octadecendienoyl-CoA + H2O2
-
-
-
-
?
oleoyl-CoA + O2
2-trans-9-trans-octadecendienoyl-CoA + H2O2
-
-
-
-
?
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
-
?
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
-
?
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
-
?
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
-
?
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
?, ir
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
-
ir
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
?, ir
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
?
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
-
?
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
-
?
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
-
-
-
-
?
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA
-
-
-
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r
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA
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-
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?
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA
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isozyme ACOX1b shows higher activity than isozyme ACOX1a
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?
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA
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-
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?
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA + H2O2
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-
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?
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA + H2O2
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-
-
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?
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA + H2O2
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-
-
-
?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
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AtACX2
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?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
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-
-
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?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
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-
-
-
?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
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-
-
-
?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
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-
-
-
?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
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-
-
-
?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
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-
-
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?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
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-
-
-
?
additional information
?
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each ACX enzyme acts on specific chain-length targets, but in a partially overlapping manner, indicating a degree of functional redundancy
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?
additional information
?
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each ACX enzyme acts on specific chain-length targets, but in a partially overlapping manner, indicating a degree of functional redundancy
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-
?
additional information
?
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isoform ACX1 shows preference for C12-C16-CoA substrates and then C18 substrates, exhibiting a peak of activity with C16 acyl-CoA, but shows a little activity with short-chain (C6) acyl-CoA and very long-chain acyl-CoA (C20)
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-
additional information
?
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isoform ACX1 shows preference for C12-C16-CoA substrates and then C18 substrates, exhibiting a peak of activity with C16 acyl-CoA, but shows a little activity with short-chain (C6) acyl-CoA and very long-chain acyl-CoA (C20)
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-
-
additional information
?
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POX4-encoded acyl-CoA oxidase shows activities to broad substrates from short-chain or long-chain fatty acids, but POX5-encoded acyl-CoA oxidase shows activities to narrow substrate spectrum such (C10 and C12)
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-
additional information
?
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POX4-encoded acyl-CoA oxidase shows activities to broad substrates from short-chain or long-chain fatty acids, but POX5-encoded acyl-CoA oxidase shows activities to narrow substrate spectrum such (C10 and C12)
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-
additional information
?
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POX4-encoded acyl-CoA oxidase shows activities to broad substrates from short-chain or long-chain fatty acids, but POX5-encoded acyl-CoA oxidase shows activities to narrow substrate spectrum such (C10 and C12)
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-
additional information
?
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CrACX2 is more active toward long chain acyl-CoAs (C18:1-, C18:0-, C20:0-, C16:0-CoAs) than to medium chain acyl-CoA (C12:0-CoA)
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?
additional information
?
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CrACX2 is more active toward long chain acyl-CoAs (C18:1-, C18:0-, C20:0-, C16:0-CoAs) than to medium chain acyl-CoA (C12:0-CoA)
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?
additional information
?
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ACOX-1 interacts with PEX-5 in peroxisomes
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-
additional information
?
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ACOX-1 interacts with PEX-5 in peroxisomes
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-
additional information
?
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isoform ACOX1 is responsible for the oxidation of straight-chain fatty acids with different chain lengths
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additional information
?
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isoform ACOX1 is responsible for the oxidation of straight-chain fatty acids with different chain lengths
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-
additional information
?
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isoform ACOX1 is responsible for the oxidation of straight-chain fatty acids with different chain lengths
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-
additional information
?
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isoform ACOX1 is responsible for the oxidation of straight-chain fatty acids with different chain lengths
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-
additional information
?
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isoform ACOX2 is the only human acyl-CoA oxidase involved in bile acid biosynthesis, and is involved in the degradation of the branched-chain fatty acids
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-
additional information
?
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isoform ACOX2 is the only human acyl-CoA oxidase involved in bile acid biosynthesis, and is involved in the degradation of the branched-chain fatty acids
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-
additional information
?
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isoform ACOX2 is the only human acyl-CoA oxidase involved in bile acid biosynthesis, and is involved in the degradation of the branched-chain fatty acids
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-
additional information
?
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isoform ACOX2 is the only human acyl-CoA oxidase involved in bile acid biosynthesis, and is involved in the degradation of the branched-chain fatty acids
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-
additional information
?
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isoform ACOX3 is involved in the degradation of the branched-chain fatty acids
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-
additional information
?
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isoform ACOX3 is involved in the degradation of the branched-chain fatty acids
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-
additional information
?
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isoform ACOX3 is involved in the degradation of the branched-chain fatty acids
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-
additional information
?
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isoform ACOX3 is involved in the degradation of the branched-chain fatty acids
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-
additional information
?
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high activity toward acyl-CoAs with a chain length of C12-C18, inactive with short chain acyl-CoAs with a chain length of C4 and C6
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-
?
additional information
?
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-
high activity toward acyl-CoAs with a chain length of C12-C18, inactive with short chain acyl-CoAs with a chain length of C4 and C6
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-
?
additional information
?
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exhibits high activity towards acyl-CoAs with chain lenghths of C12-C18
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?
additional information
?
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exhibits high activity towards acyl-CoAs with chain lenghths of C12-C18
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?
additional information
?
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high activity toward acyl-CoAs with a chain length of C12-C18, inactive with short chain acyl-CoAs with a chain length of C4 and C6
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?
additional information
?
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exhibits high activity towards acyl-CoAs with chain lenghths of C12-C18
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-
?
additional information
?
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rate-limiting enzyme of the peroxisomal beta-oxidation spiral
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?
additional information
?
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rate-limiting enzyme of the peroxisomal beta-oxidation spiral
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?
additional information
?
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PpACX1 exhibits activity with medium- to long-chain fatty acyl-CoAs, equally for C10-CoA to C16-CoA. Isozyme PpACX1 activity using C6-CoA and C10-CoA as substrates is relatively lower and both maintains constant during the reaction time, while a linear activity with C16-CoA substrate is observed
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-
?
additional information
?
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PpACX1 exhibits activity with medium- to long-chain fatty acyl-CoAs, equally for C10-CoA to C16-CoA. Isozyme PpACX1 activity using C6-CoA and C10-CoA as substrates is relatively lower and both maintains constant during the reaction time, while a linear activity with C16-CoA substrate is observed
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?
additional information
?
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key enzyme for the beta-oxidation of fatty acids
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?
additional information
?
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Eucalyptus terpenes elevate hepatic AOX expression in possum
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?
additional information
?
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Aox2p expression regulates the size of cellular triacylglycerol pools and the size and number of intracellular lipid bodies in which these gatty acids accumulate
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-
?
additional information
?
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no activity with hexadecanoyl-CoA and 3-methylheptadecanoyl-CoA
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-
?
additional information
?
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-
no activity with hexadecanoyl-CoA and 3-methylheptadecanoyl-CoA
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?
additional information
?
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isoform ACOX3 exhibits activity for short-chain acyl-CoAs (C4-C10)
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-
additional information
?
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the enzyme prefers short-chain dicarboxylyl-CoAs as a substrate
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additional information
?
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the enzyme prefers short-chain dicarboxylyl-CoAs as a substrate
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additional information
?
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the enzyme prefers short-chain dicarboxylyl-CoAs as a substrate
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additional information
?
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isoform ACOX3 exhibits activity for short-chain acyl-CoAs (C4-C10)
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-
additional information
?
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structural and functional comparison of isoforms with each other and enzymes from other species, regulatory aspects
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?