1.3.2.3: L-galactonolactone dehydrogenase
This is an abbreviated version!
For detailed information about L-galactonolactone dehydrogenase, go to the full flat file.
Word Map on EC 1.3.2.3
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1.3.2.3
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asa
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l-galactose
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dehydroascorbate
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monodehydroascorbate
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l-galactose-1-phosphate
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l-gulono-1,4-lactone
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galdh
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gdp-d-mannose
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mdhar
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gdp-l-galactose
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aldonolactone
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d-galacturonate
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ascorbate-glutathione
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smirnoff-wheeler
- 1.3.2.3
- asa
- l-galactose
- dehydroascorbate
- monodehydroascorbate
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l-galactose-1-phosphate
- l-gulono-1,4-lactone
- galdh
- gdp-d-mannose
- mdhar
- gdp-l-galactose
- aldonolactone
- d-galacturonate
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ascorbate-glutathione
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smirnoff-wheeler
Reaction
Synonyms
dehydrogenase, galactonolactone, ferricytochrome c oxidoreductase, galactono-1,4-lactone dehydrogenase, galactonolactone dehydrogenase, GALDH, GalL dehydrogenase, GalLDH, GLDase, GLDH, GLDH-A1, GLDH-B1, GLDH-D1, GLDH1, GLDHase, L-galactone-1,4-lactone dehydrogenase, L-galactono-1, 4-lactone dehydrogenase, L-galactono-1,4-lactone dehydrogenase, L-galactono-gamma-lactone dehydrogenase, L-GalLDH, L-GalLDH1, L-GalLDH2, LsL-GalLDH, RrGalLDH
ECTree
1.3.2.3 L-galactonolactone dehydrogenaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 1.3.2.3 - L-galactonolactone dehydrogenase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
Atebrin
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reaction with ferricytochrome inhibited, reaction with phenazine methosulfate not
glutathione
the enzyme activity is inhibited by 60% by reduced glutathione (GSH)
H2O2
GALDH is inactivated by hydrogen peroxide due to selective oxidation of cysteine 340, located in the cap domain
phosphate
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reaction with ferricytochrome inhibited, reaction with phenazine methosulfate stimulated
riboflavin
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reaction with ferricytochrome inhibited, reaction with phenazine methosulfate not
L-galactono-gamma-lactone
substrate inhibition at concentration above 32.6 mM
L-galactono-gamma-lactone
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substrate inhibition at concentration above 4.2 mM
additional information
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no substrate inhibition with L-gulono-1,4-lactone at concentrations up to 100 mM, D-galactono-1,4-lactone, D-gulono-1,4-lactone, L-mannono-1,4-lactone, and D-galacturonic acid do not inhibit the oxidation of L-galactono-1,4-lactone, no specific inhibition by cations or anions is observed
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additional information
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the transcript levels of L-galactono-1,4-lactone dehydrogenase is down-regulated in the dark
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additional information
no inhibition with riboflavin and lycorine
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additional information
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no inhibition with riboflavin and lycorine
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additional information
incubation of pepper crude extracts with increasing concentrations of SIN-1, a peroxynitrite donor, does not modify GalLDH activity significantly. Similarly, S-nitrosoglutathione, GSNO, an NO donor, does not affect the enzyme activity either
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additional information
the RNAi-reduced expression of GalLDH leads to up to 80% reduction in activity
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additional information
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the RNAi-reduced expression of GalLDH leads to up to 80% reduction in activity
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