1.3.1.98: UDP-N-acetylmuramate dehydrogenase
This is an abbreviated version!
For detailed information about UDP-N-acetylmuramate dehydrogenase, go to the full flat file.
Word Map on EC 1.3.1.98
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1.3.1.98
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peptidoglycan
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aureus
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fad
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udp-n-acetylmuramic
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epidermidis
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medicine
- 1.3.1.98
- peptidoglycan
- aureus
- fad
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udp-n-acetylmuramic
- epidermidis
- medicine
Reaction
Synonyms
alr5066, EC 1.1.1.158, More, MurB, MurBAb, PA2977, PaMurB, reductase, uridine diphosphoacetylpyruvoylglucosamine, type I UNAGEP reductase, UDP-GlcNAc-enoylpyruvate reductase, UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylenolpyruvyl glucosamine reductase, UDP-N-acetylenolpyruvylglucosamine reductase, UDP-N-acetylglucosamine-enoylpyruvate reductase, UDP-N-acetylmuramate dehydrogenase, UNAGEP reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase, VspiD_010100018130
ECTree
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Substrates Products
Substrates Products on EC 1.3.1.98 - UDP-N-acetylmuramate dehydrogenase
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REACTION DIAGRAM
UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+
UDP-N-acetyl-alpha-D-muramate + NADP+
UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
UDP-N-acetyl-alpha-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+
UDP-N-acetyl-alpha-D-muramate + NADP+
structural analysis of the first half-reaction, hydride transfer from NADPH to FAD using the crystal structure of the enzyme in ternary complex with FAD and NADP+, overview. Enzyme MurB is a type I UNAGEP reductase
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+
UDP-N-acetyl-alpha-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+
UDP-N-acetyl-alpha-D-muramate + NADP+
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the enzyme MurB catalyzes the reduction of the enolpyruvyl moiety of UDP-GlcNAc-enolpyruvate to lactyl ether to produce UDP-N-acetylmuramic acid
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+
UDP-N-acetyl-alpha-D-muramate + NADP+
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UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
essential for cell growth, functions in bacterial peptidoglycan biosynthesis
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetyl-3-D-muramate + NADP+
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UDP-N-acetylmuramate + NADP+
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UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
UDP-N-acetylmuramate + NADP+
i.e. enolpyruvyl-UDP-N-acetylglucosamine
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UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
complex of MurB and substrate forms strong hydrogen bond with Arg176, Ser257 and Glu361. The secondary structure of MurB consists of 13 helices, 6 beta sheets, 6 beta hairpins, 5 beta bluges, 19 stands, 52 beta turns and 4 inverse gamma turns
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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biosynthetic MurB pathway, overview
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
residues Arg213, Arg176, His259, Asn71, Tyr175, Ser226, and Glu296 are involved in catalysis
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH
UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylmuramate + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH + H+
UDP-N-acetylmuramate + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH + H+
UDP-N-acetylmuramate + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH + H+
UDP-N-acetylmuramate + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH + H+
UDP-N-acetylmuramate + NADP+
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UDP-N-acetylmuramic acid + NADP+
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UDP-N-acetylenolpyruvylglucosamine + NADPH + H+
UDP-N-acetylmuramic acid + NADP+
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enzyme catalyzes one of the cytoplasmic steps of E. coli peptidoglycan synthesis
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additional information
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enzyme catalyzes one of the cytoplasmic steps of E. coli peptidoglycan synthesis
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