1.3.1.88: tRNA-dihydrouridine16/17 synthase [NAD(P)+]
This is an abbreviated version!
For detailed information about tRNA-dihydrouridine16/17 synthase [NAD(P)+], go to the full flat file.
Reaction
Synonyms
Dus1p, tRNA-dihydrouridine synthase 1
ECTree
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General Information
General Information on EC 1.3.1.88 - tRNA-dihydrouridine16/17 synthase [NAD(P)+]
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malfunction
physiological function
formation of dihydrouridine in yeast cytoplasmic tRNAs is carried out by a family of four dihydrouridine synthases (Dus1p, Dus2p, Dus3p, and Dus4p), each acting at specific positions in tRNAs. Dus1p modifies U16 and U17, Dus2p modifies U20, Dus3p modifies U47, and Dus4p modifies U20a and U20b. These four proteins are responsible for all dihydrouridine modification of cytoplasmic tRNAs in yeast
tRNAPhe from dus1-DELTA strain has little detectable dihydrouridine compared to tRNAPhe from wild-type. tRNAPhe contains dihydrouridine at position 16 and 17
malfunction
yeast extract from a dus1-DELTA strain is completely defective in modification of yeast pre-tRNAPhe